The Effect of Vincamine on the Regional Cerebral Blood Flow in Man

Depresseux, J.C.

doi:10.1159/000114931

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…The blood flow recorded in the ischemic areas and the average blood flow in the surrounding brain during induced hypertension is also shown in table 4.…”

Section: Rcbf Recorded Over Ischemic Infarctsmentioning

confidence: 99%

“…Our own group uses a fast-rotating single photon emission tomograph for measuring the wash-out of inhaled lw xenon in 3 slices of the brain simultaneously. * 4 Both methods are primarily used to study patients with focal cerebral ischemia, in particular, patients in whom reconstructive vascular surgery is under consideration. However, while these tomographic approaches avoid the look-through phenomenon, Compton scatter interference cannot be entirely avoided.…”

Section: Comments On the Low Rcbf Values Recorded Orer Infarctsmentioning

confidence: 99%

See 1 more Smart Citation

Focal cerebral ischemia measured by the intra-arterial 133xenon method. Limitations of 2-dimensional blood flow measurements.

Olsen¹,

Larsen²,

Skriver³

et al. 1981

Stroke

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SUMMARY The limitations of 2-dlmendooal isotope techniques in the study of focal cerebral ischemia were investigated using the intra-carotid '"xenon injection method and a 254 multidetector scintillation camera. To make sure that the detectors "look" directly on infarcted areas, only patients with infarcts involving cortical surface structures were included in the study. Eleven such patients were found among 43 consecutive patients with completed stroke, all investigated with CT-scan. The blood supply to the infarcted areas was evaluated using 3 different approaches: 1) The first minute washout of '"xenon (rCBF), 2) the initial distribution of isotope during the first 5 sec and 3) the cumulated counts recorded during 15 mm. Compton scatter and the "look through phenomenon" were responsible for the majority of counts recorded from the infarcted areas and the blood flow recorded was found to be grossly overestimated and much more influenced by the blood flow in the surroundings than in the iscbemlc area itself. However, using the 3 approaches, infarcted areas were always disclosed by our equipment.It is concluded that 2-dlmensional isotope technique is not reliable for quantifying focal ischemic lesions. The method should be limited to the qualitative demonstration of the ischemic lesions for which it is fully reliable.

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“…The blood flow recorded in the ischemic areas and the average blood flow in the surrounding brain during induced hypertension is also shown in table 4.…”

Section: Rcbf Recorded Over Ischemic Infarctsmentioning

confidence: 99%

Section: Comments On the Low Rcbf Values Recorded Orer Infarctsmentioning

confidence: 99%

Focal cerebral ischemia measured by the intra-arterial 133xenon method. Limitations of 2-dimensional blood flow measurements.

Olsen¹,

Larsen²,

Skriver³

et al. 1981

Stroke

View full text Add to dashboard Cite

show abstract

“…For example, Depresseux (1978) has shown that the intracarotid administration of vincamine increases the blood flow in the ischaemic foci and reduces blood flow in the hyperaemic regions of cerebrovascular disease. This "inverse steal phenomenon" has been observed with vincamine and a few related agents in other clinical studies (Herrschaft, 1977;Heiss and Podreka, 1978).…”

Section: Use Of Vasoactive Drugs In Focal Cerebral Ischaemiamentioning

confidence: 99%

Direct Vascular Effects of Agents Used in the Pharmacotherapy of Cerebrovascular Disease on Isolated Cerebral Vessels

Young

Bouloy

Boussard

et al. 1981

J Cereb Blood Flow Metab

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Summary:The direct vasomotor effects of a number of agents used in the therapy of cerebral circulatory and metabolic disease were studied in isolated segments of cat pial vessels in vitro, Studies were repeated eight times gener ally, thus permitting the calculation of the mean maximum response-termed ifenprodil > vincamine > nicergoline > dihydroergotoxine > raubasine, In addition, it was considered worthwhile to determine whether the ifenprodil induced vasoconstriction occurred when human, rather than cat, pial vessels were studied, Ifenprodil and vincamine contracted the human vessels in a biphasic manner; the EC,;o was calculated to be 2,0 and 30 JLM, Based on the above observations, the following comments would appear justified, Firstly, an increase in cerebral blood flow does not necessarily mean a compound is a direct vasodilator. Secondly, the vasoconstrictory actions of some agents cor relate well with their anti-ischaemic properties (e,g" ifenprodil, vincamine, and nicergoline), Lastly, one action of effective anti-ischaemic agents might be to reduce flow, by vasoconstriction, in hyperaemic tissue: the inverse "steal" effect. Key Words: In vitro -a-adrenolytic agents-Middle cerebral artery Tension-Cat-Human.

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Pharmacology, Biochemistry, and Clinical Applications of the Monoterpenoid Alkaloids

Creasey

1983

Chemistry of Heterocyclic Compounds: A Series of Monographs

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The Effect of Vincamine on the Regional Cerebral Blood Flow in Man

Cited by 10 publications

References 7 publications

Focal cerebral ischemia measured by the intra-arterial 133xenon method. Limitations of 2-dimensional blood flow measurements.

Focal cerebral ischemia measured by the intra-arterial 133xenon method. Limitations of 2-dimensional blood flow measurements.

Direct Vascular Effects of Agents Used in the Pharmacotherapy of Cerebrovascular Disease on Isolated Cerebral Vessels

Pharmacology, Biochemistry, and Clinical Applications of the Monoterpenoid Alkaloids

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