Isolation of a novel catechin from Bergenia rhizomes that has pronounced lipase-inhibiting and antioxidative properties

Ivanov, Sergey A.; Nomura, Kenzo; Malfanov, Ilya L.; Sklyar, Ilya V.; Ptitsyn, Leonid R.

doi:10.1016/j.fitote.2010.09.013

Cited by 44 publications

(31 citation statements)

References 28 publications

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“…O-digallate [7][8][9]. Such compounds perform various biological activities including the reduction of cholesterol and anti-cancer and anti-oxidant activities.…”

Section: Catechin-35-o-digallate (-)-Epicatechin (-)-Epicatechin-3mentioning

confidence: 99%

(⿿)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase

Lee

Sun

et al. 2016

International Journal of Biological Macromolecules

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“…O-digallate [7][8][9]. Such compounds perform various biological activities including the reduction of cholesterol and anti-cancer and anti-oxidant activities.…”

Section: Catechin-35-o-digallate (-)-Epicatechin (-)-Epicatechin-3mentioning

confidence: 99%

(⿿)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase

Lee

Sun

et al. 2016

International Journal of Biological Macromolecules

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“…1). These compounds were identified as (–)-epicatechin-3- O - (Z) -coumarate ( 1 ), (–)-epicatechin-3- O - (E) -coumarate ( 2 ) 9 , (–)-epicatechin-3- O -( E )-caffeate ( 3 ) 10 , (+)-catechin ( 4 ) 11 , ampelopsin ( 5 ) 12 , (–)-epicatechin ( 6 ) 11 , (–)-epiafzelechin ( 7 ) 13 , (–)-epicatechin-3- O -gallate ( 8 ) 11 , (–)-epiafzelechin-3- O -gallate ( 9 ) 11 , (+)-catechin-3- O -gallate ( 10 ) 14 , (+)-epiafzelechin-3- O -gallate ( 11 ) 15 , epicatechin- 3- O - p -hydroxybenzoate ( 12 ) 16 , (–)-epigallo-catechin ( 13 ) 11 , (±)-gallocatechin ( 14 ) 11 , (–)-epigallo-catechin-3- O -gallate ( 15 ) 11 , (+)-gallocatechin-3- O -gallate ( 16 ) 17 and (–)-epicatechin-3- O -(3′′- O -methyl)-gallate ( 17 ) 18 .…”

Section: Resultsmentioning

confidence: 99%

Flavanols from the Camellia sinensis var. assamica and their hypoglycemic and hypolipidemic activities

Wang

Liu

Zhu

et al. 2017

Acta Pharmaceutica Sinica B

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α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia. To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flavanol, named (–)-epicatechin-3-O-(Z)-coumarate (1), and 16 known analogs (2—17) were isolated from the aqueous extract of the pu-erh tea. Their structures were determined by spectroscopic and chemical methods. Furthermore, the water extract of pu-erh tea and its fractions exhibited inhibitory activities against α-glucosidases and lipases in vitro; compound 15 showed moderate inhibitory effect against sucrase with an IC50 value of 32.5 μmol/L and significant inhibitory effect against maltase with an IC50 value of 1.3 μmol/L. Compounds 8, 10, 11 and 15 displayed moderate activity against a lipase with IC50 values of 16.0, 13.6, 19.8, and 13.3 μmol/L, respectively.

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“…The preparation of the plant extracts was carried out by Dr. I. Malfanov and Dr. S. Ivanov (Ajinomoto-Genetika Research Institute), and the dried plant material was prepared as previously described [15]. Briefly, approximately 10 g of each plant was dried and crushed in a mill (if necessary) and soaked in 70% aqueous ethanol (1 : 40, w/v) with stirring (200 rpm) overnight at room temperature.…”

Section: Experimental Conditionsmentioning

confidence: 99%

In Vitro Study of the Anti-Inflammatory Activity of Some Medicinal and Edible Plants Growing in Russia

2013

JCPRM

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The effects of the ethanolic extracts of 105 plants used in Russian traditional medicine, 26 vegetables and fruits and 2 mushrooms on the release of tumor necrosis factor (TNF-) and prostaglandin E 2 (PGE 2 ) in lipopolysaccharide (LPS)-stimulated differentiated human acute monocytic leukemia THP-1 cells were studied using TNF-and PGE 2 assays, respectively. We found that 16 plant extracts inhibited TNF-production and 15 extracts decreased PGE 2 release in the cells in a concentration-dependent manner. Guilder rose, tansy, shrubby cinquefoil, wintergreen and prince's pine, the last two of which belong to the Pyrolaceae family, notably inhibited the levels of both of the inflammatory mediators.

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Isolation of a novel catechin from Bergenia rhizomes that has pronounced lipase-inhibiting and antioxidative properties

Cited by 44 publications

References 28 publications

(⿿)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase

(⿿)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase

Flavanols from the Camellia sinensis var. assamica and their hypoglycemic and hypolipidemic activities

In Vitro Study of the Anti-Inflammatory Activity of Some Medicinal and Edible Plants Growing in Russia

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