Isolation of a new meroterpene and inhibitors of nitric oxide production from Psoralea corylifolia fruits guided by TLC bioautography

Xiao, Gao; Li, Xiangkun; Wu, Tao; Cheng, Zhihong; Tang, Qingjiu; Zhang, Tong

doi:10.1016/j.fitote.2012.08.024

Cited by 23 publications

(17 citation statements)

References 22 publications

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“…Angelicin (Isopsoralen) (2) n (Innocenti et al, 1997) [ and Bhakuni, 2010; Wang et al, 2014;Won et al, 2015;Wu et al, 2007 a, b;Wu et al, 2008;Xiao et al, 2012;Xu et al, 2012;Yadava and Verma, 2003;Yadava and Verma, 2005;Yang et al, 2006;Yang et al, 2009;Yin et al, 2004;Yu et al, 2005;Zhang et al, 2016;Zhao et al, 2005a) Bakuchicin (…”

Section: Rhizomementioning

confidence: 99%

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

Koul

Taak

Kumar

et al. 2019

Journal of Ethnopharmacology

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A B S T R A C TEthnopharmacological relevance: The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria bituminosa (Syn: P. bituminosa), P. canescens, P. corylifolia, P. esculenta, P. plicata and P. glandulosa which are valued for their chemical constituents and traditional uses. Aim of the review: This review article provides explicit information on traditional uses, phytochemistry, and pharmacological activities of selected Psoralea species. The possible trends and perspectives for future research on these plants are also discussed. Materials and methods: An extensive and systematic review of the extant literature was carried out, and the data under various sections were identified using a computerized bibliographic search via the PubMed, Web of Science and Google Scholar, CAB Abstracts, MEDLINE, EMBASE, INMEDPLAN, NATTS as well as several websites. Key findings: A total of 291 bioactive compounds from 06 species of genus Psoralea have been isolated and characterized. However, P. bituminosa alone possess nearly 150 compounds. These bioactive compounds belong to different chemical classes, including flavonoids, coumarins, furanocoumarins, chalcones, quinines, terpenoids and some others due to which these species exhibit significant anti-oxidant, anti-bacterial, anti-fungal, anti-viral, anti-helmintic, anti-diabetic, diuretic, hepatoprotective, anti-cancer and anti-tumor activities. P. corylifolia L. (Babchi), a Chinese traditional medicinal plant has been used in traditional medicine for many decades for its healing properties against numerous skin diseases such as leprosy, psoriasis and leucoderma. Conclusions: The in vitro studies and in vivo models have provided a simple bio-scientific justification for various ethnopharmacological uses of Psoralea species. From the toxicological perspective, the root, leaf, and seed extracts and their preparations have been proven to be safe when consumed in the recommended doses. But, meticulous studies on the pharmaceutical standardization, mode of action of the active constituents, and sustainable conservation of Psoralea species are needed, to meet the growing demands of the pharmaceutical industries, and to fully exploit their preventive and therapeutic potentials.

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Section: Rhizomementioning

confidence: 99%

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

Koul

Taak

Kumar

et al. 2019

Journal of Ethnopharmacology

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Section: Bioautographic Enzyme Assaysmentioning

confidence: 99%

“…Another approach used the bioautographic XO assay to identify inhibitors of the enzyme nitric oxide synthase (NOS) (Xiao et al , ). NOS is responsible for the excessive production of nitric oxide, superoxide and their reaction product peroxynitrite (Xiao et al , ). Nitric oxide is one of the main bioactive signalling molecules implicated in infections and inflammatory disorders by promoting oxidative stress and tissue injury (Víteček et al , ; Xiao et al , ).…”

Section: Bioautographic Enzyme Assaysmentioning

confidence: 99%

Recent Advances in Effect‐directed Enzyme Assays based on Thin‐layer Chromatography

Bräm

Wolfram

2017

Phytochemical Analysis

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Thin-layer chromatography (TLC) together with its more modern form high-performance thin-layer chromatography (HPTLC) is a rapid and cost effective analytical tool with a long tradition in quality control of medicinal plants, extracts and natural products. Separated compounds are fixed on the solid silica phase to form a compound library. Through direct coupling of visualisable enzyme reactions on the TLC plate, this compound library can also be used for activity screening. Such TLC-based bioautographic enzyme and enzyme inhibition assays complement first stage development activity screening assays. They provide not only phytochemical results by chromatographic separation, but also additional information about the activity of constituents or fractions in multi-compound mixtures, and thus can reveal and distinguish artefacts generated by certain compound classes. This review summarises recently introduced TLC bioautographic enzyme assays as well as advances in already existing procedures. Bioautographic enzyme and enzyme inhibitory assays offer a rapid, high-throughput method for screening of secondary metabolite profiles for potential enzyme and enzyme inhibitory activities. Copyright © 2017 John Wiley & Sons, Ltd.

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“…The inhibitory effect on NO production in RAW264.7 cells was tested by a previously reported method [9]. Briefly, RAW264.7 cells were placed in 96-well plates at a density of 2×10 5 identified as sigmoside C (8) [10], soyasapogenol B (9) [11], soyasaponin I methyl ester (10) [12], medicarpin (11) [13], medicarpin 3-O--D-glucoside (12) [5], maackiain (13) [14], trifolirhizin (14) [22,23].…”

Section: Nitrite Assaymentioning

confidence: 99%

Pterocarpans and triterpenoids from Gueldenstaedtia verna

Yin

Zhou

et al. 2015

Fitoterapia

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Isolation of a new meroterpene and inhibitors of nitric oxide production from Psoralea corylifolia fruits guided by TLC bioautography

Cited by 23 publications

References 22 publications

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

Recent Advances in Effect‐directed Enzyme Assays based on Thin‐layer Chromatography

Pterocarpans and triterpenoids from Gueldenstaedtia verna

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