Isolation of a new flavonoid and waste to wealth recovery of 6-O-Ascorbyl Esters from Seeds of Aegle marmelos (family- Rutaceae)

Abstract

Aegle marmelos is a plant species native to India. Commercially available food products such as jam, jelly, candy, squash etc. are prepared from ripe fruit pulp of A. marmelos. Ripe fruit processing accounts for 60% of whole fruit mass while 40% remains unutilized and generates waste (hard shell, pomace, fiber and seeds) on a massive scale which do not have high value applications. A new flavone 3,5,7-trihydroxy-2-(4'-hydroxy-3'-isopentyloxyphenyl-4H-chromen-4-one (5) in addition to the known compounds 1-4, has been isolated from seeds of A. marmelos. Also, compound 7-(3'-methylbut-2'-enyloxy)-2H-chromen-2-one (2) has been isolated for the first time from A. marmelos. The structure of compounds 1-5 was determined by spectral analysis (UV, IR, NMR, etc.). Additionally, the non-edible oil obtained from seeds was investigated for waste to wealth recovery of 6-O-ascorbyl esters in high regioselectivity via one step semi-synthetic approach in the presence of ascorbic acid and HSO at ambient temperature.

Evaluation of Neuropharmacological Activities of Methanolic and Aqueous Extracts of Citrus Reticulata (Rutaceae) Fruit Peels

“…Despite of chief scientific and technological development in combinatorial chemistry, drugs obtained from natural products still create a huge contribution to drug discovery today. The citrus plant belongs to the family Rutaceae, comprising of about seventeen species found all over the tropical, subtropical and temperate regions [38,39]. Among the species, Citrus indica, Citrus ichangenesis Citrus latipes, Citrus megaloxycarpa, Citrus macroptera, Citrus jambhiri, Citrus aurantium, and Citrus reticulate are the most common.…”

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

“…A. marmelos of the Rutaceae family is known most often as the ‘bael’ tree in subcontinent regions and as the ‘wood apple’ in other parts of the world [ 46 , 47 ]. All parts of this plant (leaf, root, seed, bark, and fruit) contain medicinal properties and have many active chemical constituents, such as flavonoids (e.g., flavone and rutin) [ 48 , 49 ], tannins (e.g., skimmianine) [ 50 ], phenylpropanoids (e.g., lignans and phenylpropenes) [ 51 ], saponins, luvangetin, coumarins (e.g., xanthotoxol, marmelosin, and scoparone) [ 52 ], carbohydrates (e.g., galactose, L-rahamanos, etc. ), terpenoids, essential oils (e.g., phellandrene, limonene, ocimene, and pinene) [ 53 ], ester, and alkaloids (e.g., skimmiarepin and cinnamamide) [ 54 , 55 ].…”