Isolation of a herpesvirus from the canine genital tract: association with infertility, abortion and stillbirths

Poste, George; King, N.

doi:10.1136/vr.88.9.229

Cited by 61 publications

(35 citation statements)

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“…It was suggested that the lumbosacral ganglion was an important site for latency and that recrudescent virus played an important role in venereal infections [4]. Since CHV infection in pregnant dogs causes abortion and stillbirth, the mechanism of reactivation of CHV should be clarified [9,15].…”

Section: Discussionmentioning

confidence: 99%

Detection of Canine Herpesvirus DNA in the Ganglionic Neurons and the Lymph Node Lymphocytes of Latently Infected Dogs.

Miyoshi

Ishii

Takiguchi

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. To determine the site of latent infection of canine herpesvirus (CHV), tissues from dogs convalescent from acute infection with CHV were examined for the presence of viral genome DNA by the nested polymerase chain reaction. CHV DNA was detected in the trigeminal ganglia and the retropharyngeal lymph nodes. In situ hybridization study of the tissues revealed that CHV genome persisted in the nuclei of ganglionic neurons and lymphocytes.-KEY WORDS: canine herpesvirus, ganglionic neuron, latency, lymphocyte.

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Section: Discussionmentioning

confidence: 99%

Detection of Canine Herpesvirus DNA in the Ganglionic Neurons and the Lymph Node Lymphocytes of Latently Infected Dogs.

Miyoshi

Ishii

Takiguchi

et al. 1999

The Journal of Veterinary Medical Science

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“…CHV-1 is of low pathogenicity in puppies older than 5 weeks [6] and may cause tracheobronchitis in adult dogs [7]. Apart from the important disease in newborn puppies, CHV-1 also affects reproduction of dogs in other ways: the virus may cause vesicular lesions in the vestibulum and vagina of the bitch, as well as on the penis and the preputial mucosa of dogs [8] and may cause fetal death, abortion and stillbirths [8] and [9]. CHV-1 thus poses a serious disease to the reproductive efficiency of breeding kennels.…”

Section: Introductionmentioning

confidence: 99%

“…CHV-1 thus poses a serious disease to the reproductive efficiency of breeding kennels. The virus is transmitted oronasally [1], transplacentally [9] and venereally [8]. Lesions in the vestibulum and vagina of bitches may recur when bitches come into proestrus and regress when they go into anestrus [8].…”

Section: Introductionmentioning

confidence: 99%

“…The virus is transmitted oronasally [1], transplacentally [9] and venereally [8]. Lesions in the vestibulum and vagina of bitches may recur when bitches come into proestrus and regress when they go into anestrus [8]. Affected animals may remain latent carriers [10], and the virus was identified in the lumbosacral ganglia, tonsils, parotid salivary glands and liver of dogs that showed no sign of herpesvirus infection [11].…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of canine herpesvirus in breeding kennels in the Gauteng Province of South Africa

et al. 2008

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Canine herpesvirus (CHV-1) causes neonatal deaths as well as infertility due to embryonal death, abortion and stillbirths in breeding kennels. The aim of this study was to determine the prevalence of antibodies against canine herpesvirus in the serum of dogs older than 1 year in breeding kennels in the Gauteng Province of South Africa. A serum neutralization test (SNT) and a newly developed enzyme linked immunosorbent assay (ELISA) were used to test the serum samples of 328 dogs in 38 breeding kennels. With SNT as well as ELISA, 22% of sera were positive (P > 0.9). Seventeen kennels (45% of total kennels) each had at least one positive dog on SNT compared with twenty kennels (53% of total kennels) that each had at least one positive dog on ELISA (P = 0.6). The prevalence of positive dogs in positive kennels was 42 ± 26% (n = 17 kennels) for SNT and 39 ± 26% (n = 20 kennels) for ELISA. Pairwise comparison of kennels showed that the prevalence of SNT positive dogs was similar to the prevalence of ELISA positive dogs (P = 0.3, n = 38 kennels). Seroprevalence was independent of age, gender or colony size. This study suggests that canine herpesvirus is sufficiently common in breeding dogs in the Gauteng Province of South Africa to pose a threat to neonatal survival and fertility.

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“…A virus, designated CHV-BR, isolated from vesicular lesions affecting the genitals of dogs has been classified provisionally as a herpesvirus (22). In this paper, the basic charactcristics of the agent are defined which confirm its classification as a herpesvirus.…”

Section: Introductionmentioning

confidence: 86%

Characterization of a new canine herpes virus

Poste¹

1972

Archiv f Virusforschung

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SummaryA cytopathogenic agent, designated CHV-BI%, isolated from genital lesions in dogs has been shown to be a herpesvirus. It contained DNA, was ether-and heat-sensitive, and was unstable at low pH. Electron micrographs revealed a virion of typical herpesvirus structure. The CHV-BR isolate produced a marked cytopathic effect (CPE) in dog kidney cell cultures but failed to grow in rabbit kidney and human cell lines. The CPE in dog kidney cells consisted of extensive polykaryocytosis, and the formation of intranuclear type-A inclusion bodies. The emergence of a non-polykaryocytogenic CPE variant during serial passage of the isolate in dog cells was described. Neutralization and immunofluorescence tests showed that CHV-BI~ was serologically similar to the F-205 strain of canine herpesvirns (CHV) but was not related to other human and animal herpesviruses. Differences between the CHV-BR isolate and the CHV strains isolated elsewhere were discussed.

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Isolation of a herpesvirus from the canine genital tract: association with infertility, abortion and stillbirths

Cited by 61 publications

References 0 publications

Detection of Canine Herpesvirus DNA in the Ganglionic Neurons and the Lymph Node Lymphocytes of Latently Infected Dogs.

Detection of Canine Herpesvirus DNA in the Ganglionic Neurons and the Lymph Node Lymphocytes of Latently Infected Dogs.

Seroprevalence of canine herpesvirus in breeding kennels in the Gauteng Province of South Africa

Characterization of a new canine herpes virus

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