Isolation, full genomic characterization and neutralization-based human seroprevalence of Medjerda Valley virus, a novel sandfly-borne phlebovirus belonging to the Salehabad virus complex in northern Tunisia

Bichaud, Laurence; Dachraoui, Khalil; Alwassouf, Sulaf; Alkan, Cigdem; Mensi, Mohamed; Piorkowski, Géraldine; Sakhria, Sonia; Seston, Morgan; Fares, Wasfi; Lamballerie, Xavier De; Zhioua, Elyes; Charrel, Rémi N.

doi:10.1099/jgv.0.000389

Cited by 20 publications

(17 citation statements)

References 30 publications

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“…Tesh et al [29] did not detect NT-Abs against Salehabad virus (SALV) in human populations suggesting that SALV was not infecting humans. In contrast, NT-Abs against Medjerda Valley virus were described in 1.35% (14/1260) of human sera collected from the general population living in Northern Tunisia [24]. This suggests that at least some viruses belonging to the Salehabad complex can infect humans and other vertebrates.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Alwassouf

Christodoulou²,

Bichaud

et al. 2016

PLoS Negl Trop Dis

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Phleboviruses transmitted by sandflies are endemic in the Mediterranean area. The last decade has witnessed the description of an accumulating number of novel viruses. Although, the risk of exposure of vertebrates is globally assessed, detailed geographic knowledge is poor even in Greece and Cyprus where sandfly fever has been recognized for a long time and repeatedly. A total of 1,250 dogs from mainland Greece and Greek archipelago on one hand and 422 dogs from Cyprus on the other hand have been sampled and tested for neutralising antibodies against Toscana virus (TOSV), Sandfly fever Sicilian virus (SFSV), Arbia virus, and Adana virus i.e. four viruses belonging to the 3 sandfly-borne serocomplexes known to circulate actively in the Mediterranean area. Our results showed that (i) SFSV is highly prevalent with 71.9% (50.7–84.9% depending on the region) in Greece and 60.2% (40.0–72.6%) in Cyprus; (ii) TOSV ranked second with 4.4% (0–15.4%) in Greece and 8.4% (0–11.4%) in Cyprus; (iii) Salehabad viruses (Arbia and Adana) displayed also substantial prevalence rates in both countries with values ranging from 0–22.6% depending on the region and on the virus strain used in the test. These results demonstrate that circulation of viruses transmitted by sand flies can be estimated qualitatively using dog sera. As reported in other regions of the Mediterranean, these results indicate that it is time to shift these viruses from the "neglected" status to the "priority" status in order to stimulate studies aiming at defining and quantifying their medical and veterinary importance and possible public health impact. Specifically, viruses belonging to the Sandfly fever Sicilian complex should be given careful consideration. This calls for implementation of direct and indirect diagnosis in National reference centers and in hospital microbiology laboratories and systematic testing of unelucidated febrile illness and central and peripheral nervous system febrile manifestations.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Alwassouf

Christodoulou²,

Bichaud

et al. 2016

PLoS Negl Trop Dis

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“…Accumulating reports indicate novel associations of diseases with phleboviruses in the Mediterranean area, such as sandfly fever Turkey virus (SFTV) [ 45 , 46 , 47 ] and Adria virus (ADRV) [ 48 ], or describe still more novel phleboviruses, such as Granada virus (GRV) [ 49 ], Adana virus (ADAV) [ 3 ] and Medjerda Valley virus (MVV) [ 7 ], to name only a few examples.…”

Section: Phleboviruses—an Emerging Group Of Arthropod-transmitted mentioning

confidence: 99%

“…According to the International Committee on Taxonomy of Viruses (ICTV), the genus Phlebovirus comprises more than 70 accepted members that are grouped into ten species complexes, namely Bujaru virus (BUJV), Candiru virus (CDUV), Chilibre virus (CHIV), Frijoles virus (FRIV), Punta Toro virus (PTV), Rift Valley fever virus (RVFV), Salehabad virus (SALV), sandfly fever Naples virus (SFNV), severe fever with thrombocytopenia syndrome virus (SFTSV), and Uukuniemi virus (UUKV), as well as unassigned viruses [ 2 ]. Phleboviruses were traditionally classified by serologic methods, but recently extensive efforts were undertaken to refine phlebovirus taxonomy by genome sequencing [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Phleboviruses and the Type I Interferon Response

Wuerth

Weber

2016

Viruses

104

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The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly fever Sicilian virus (SFSV), Toscana virus (TOSV), Punta Toro virus (PTV), and the two new members severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV). The nonstructural protein NSs is well established as the main phleboviral virulence factor in the mammalian host. NSs acts as antagonist of the antiviral type I interferon (IFN) system. Recent progress in the elucidation of the molecular functions of a growing list of NSs proteins highlights the astonishing variety of strategies employed by phleboviruses to evade the IFN system.

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“…During the last decade, the Salehabad virus species which contained initially only Salehabad and Arbia viruses has greatly increased by addition of newly discovered viruses such as Adana virus, Alcube virus and Medjerda Valley virus, respectively, isolated from sandflies collected in Turkey, Portugal and Tunisia [37][38][39][40]106]. Several other viruses were not isolated but discovered through sequencing a part of their genome such as Adria virus (Albania and Greece), Edirne virus (Turkey) and Olbia virus (France) [23,39,107,108].…”

Section: Other Phlebovirusesmentioning

confidence: 99%

Sandfly-Borne Viruses of Demonstrated/Relevant Medical Importance

Ayhan¹,

Charrel²

2019

Vectors and Vector-Borne Zoonotic Diseases

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Sandflies show distribution in a vast geographical area from Europe to Asia, Africa, Australia, and Central and South America where they can transmit a large number of viruses. Between these viruses, the most important are grouped into the Phlebovirus genus (family Phenuiviridae). Among them, several sandfly-borne phleboviruses cause self-limiting febrile disease (sandfly fever) or central and peripheral nervous system infections. Data concerning the geographic distribution of these phleboviruses has drastically increased during the last decade in both the new and the old worlds. The current situation depicts a high viral diversity with taxonomic groups containing human pathogenic and non-pathogenic viruses. This merits to provide insight to address the question of medical and veterinary public health impact of all these viruses, which are poorly studied. To do so, integrated and translational approaches must use ecological, epidemiological, serological and direct clinical evidence. Beside, other viruses transmitted by sandflies and belonging to Rhabdoviridae and Reoviridae families can also be of veterinary and public health importance. The chapter aims to provide a comprehensive view of the sandfly-borne viral pathogens of the public health impact on humans and other vertebrates in the old and new worlds.

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Isolation, full genomic characterization and neutralization-based human seroprevalence of Medjerda Valley virus, a novel sandfly-borne phlebovirus belonging to the Salehabad virus complex in northern Tunisia

Cited by 20 publications

References 30 publications

Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Phleboviruses and the Type I Interferon Response

Sandfly-Borne Viruses of Demonstrated/Relevant Medical Importance

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