Isolation, Characterization, Molecular Docking and in vitro Studies of Inhibitory Effect on the Growth of Struvite Crystal Derived from Melia dubia Leaf Extract

Jeyaleela, G. Dayana; Vimala, J. Rosaline; Senthil, Renganathan; Anandagopu, P.; Manjula, K.

doi:10.14233/ajchem.2019.22217

Cited by 7 publications

(4 citation statements)

References 20 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…vulgaris [ 21 ]. The proposed mechanism of rutin is to prevent folic acid synthesis [ 22 ] and rutin acts as a urease inhibitor [ 23 ]. The present study indicated that SAEE could affect the growth and virulent factors (swarming motility and urease activity) of P .…”

Section: Discussionmentioning

confidence: 99%

Anti-Proteus Activity, Anti-Struvite Crystal, and Phytochemical Analysis of Sida acuta Burm. F. Ethanolic Leaf Extract

et al. 2022

View full text Add to dashboard Cite

Proteus mirabilis is a significant cause of urinary tract infection that may contribute to struvite stones. Anti-infection of this bacterium and anti-struvite formation must be considered. Sida acuta Burm. F. (SA) has been used for the treatment of diseases related to kidneys. Therefore, we investigated the effects of the SA leaf ethanolic extract (SAEE) on growth and on virulent factors (swarming motility and urease activity) of Proteus mirabilis isolated from kidney stone formers. We also evaluated anti-struvite crystal formation and phytochemical constituents of SAEE. The minimum inhibitory concentrations (MICs) of SAEE against three clinical P. mirabilis isolates were 8 mg/mL. Intriguingly, the 1/2MIC of SAEE had significant inhibitory effects on the swarming motility and urease activity of clinical P. mirabilis isolates when compared with the condition without SAEE. The SAEE at the various concentrations significantly inhibited the average weights of struvite crystals in a dose-dependent manner, compared with the control. The phytochemical analysis revealed that SAEE contained catechin, chlorogenic acid, rutin, and ferulic acid. This study indicated that SAEE has anti-P. mirabilis and anti-struvite crystal activities via its bioactive compounds. For this reason, SAEE may be developed as a new agent for the treatment of struvite stone induced by P. mirabilis.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Proteus Activity, Anti-Struvite Crystal, and Phytochemical Analysis of Sida acuta Burm. F. Ethanolic Leaf Extract

et al. 2022

View full text Add to dashboard Cite

show abstract

“…As a result, nanoscale organic and inorganic particles are receiving increasing attention in medical applications, due to their amenability to biological functionalization. Advances in nanotechnology have led to significant development in various areas, including nanoparticles, nanotubes and the synthesis of nanofils 5,6 . The medicinal plant extract mediated metal oxide nanoparticles were recently got attention which are more popular due to its eco-friendly approach, low-cost, and no or less toxic compared with the physical and chemical procedures.…”

Section: Who (World Health Organization)mentioning

confidence: 99%

Antidiabetic Potential of Copper Oxide Nanoparticles Using Biological and Polymer Functionalized Method Mediated by Sarcostemma acidum Stem Extract

Roseline

Priya

2023

Orient. J. Chem

View full text Add to dashboard Cite

The nano sized copper oxide material (CuONPs) were prepared by the greener way and an approach functionalized by polymer using Sarcostemma acidum stem extracts. The in-vitro anti-diabetic activity was studied through the α-glucosidase and α-amylase inhibitory methods were demonstrated in Sarcostemma acidum stem, biological synthesized CuONPs and polymerized CuONPs. The percentage inhibition at 100 μg/ml, 200 μg/ml, 300 μg/ml, 400 μg/ml and 500μg/ml concentrations of Sarcostemma acidum stem, biological synthesized and polymerised CuONPs showed dose dependent inhibition in α-amylase and α-glucosidase. Throughout the studies, polymerized CuONPs showed highest inhibition of α-amylase and α-glucosidase as compared with green synthesis.

show abstract

“…At predetermined time intervals, 5 ml of the release medium was removed and replaced with 5 ml of fresh phosphate buffer solution pH 6.8. The samples were analyzed for cumulative percent drug dissolved/released by UV spectrophotometry [17].…”

Section: E) In-vitro Drug Release Studiesmentioning

confidence: 99%

Formulation and Characterization of Rutin Loaded Chitosan Nanoparticles

Raju¹,

Srivani²,

V³

et al. 2022

AJRIMPS

View full text Add to dashboard Cite

New drug delivery technologies are transforming drug discovery and development, as well as establishing research and development-focused pharmaceutical firms that are accelerating global progress. The bioactive rutin molecule is used in a wide range of food and medicinal goods. Its limited bioavailability and poor water solubility are major issues. Rutin is a polyphenolic natural compound with antibacterial, anticancer, antioxidant, chemopreventive, and anti-inflammatory activities. However, no research has been published to yet to improve its bioavailability and efficacy. As a result, an attempt was made in this study to load rutin into a nanoparticlulate system in order to improve its bioavailability and efficacy. Six formulations (F1-F6) of nanoparticles were prepared by solvent evaporation technique and were evaluated for particle size and shape using Zeta Sizer, Scanning Electron Microscopy (SEM) and Fourier Transform Infra-Red (FT-IR) Spectroscopy. The optimized formulation was further subjected to in vitro evaluation. Practical percent yield, drug entrapment efficiency and In vitro drug release were evaluated. Out of various formulations F1 have shown best results in particle size 80.71 (1-100 nm), particle shape (spherical nanoparticles with a smoothed surface), average size distribution (105.0), zeta potential (-20.6) percentage yield (70.83), drug entrapment efficiency (83.6%) and drug loading (95%). Pure rutin showed incomplete dissolution of 47.69% in 330 min while Rutin loaded nanoparticles gave 94.75% release in 330 min. It is obvious from the foregoing that rutin chitosan nanoparticles were used as a novel drug delivery technology to improve therapeutic efficacy and sustained release features while overcoming issues such as poor solubility and limited bioavailability.

show abstract

Isolation, Characterization, Molecular Docking and in vitro Studies of Inhibitory Effect on the Growth of Struvite Crystal Derived from Melia dubia Leaf Extract

Cited by 7 publications

References 20 publications

Anti-Proteus Activity, Anti-Struvite Crystal, and Phytochemical Analysis of Sida acuta Burm. F. Ethanolic Leaf Extract

Anti-Proteus Activity, Anti-Struvite Crystal, and Phytochemical Analysis of Sida acuta Burm. F. Ethanolic Leaf Extract

Antidiabetic Potential of Copper Oxide Nanoparticles Using Biological and Polymer Functionalized Method Mediated by Sarcostemma acidum Stem Extract

Formulation and Characterization of Rutin Loaded Chitosan Nanoparticles

Contact Info

Product

Resources

About