Isolation, characterization, and structural elucidation of 4-methoxyacetanilide from marine actinobacteria Streptomyces sp. SCA29 and evaluation of its enzyme inhibitory, antibacterial, and cytotoxic potential

Siddharth, Saket; Vittal, Ravishankar Rai

doi:10.1007/s00203-019-01634-y

Cited by 20 publications

(13 citation statements)

References 22 publications

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“…Other carbon sources reported to increase the production of compounds with anti-infective potential were glucose [ 18 , 27 , 33 ], sucrose [ 37 , 132 , 144 ] starch–glucose [ 23 , 31 , 94 ] among others.…”

Section: Resultsmentioning

confidence: 99%

“…Consequently, microorganism-derived compounds have been used based on a wide variety of biological activities. Among the bacteria, the actinobacteria phylum represents a noteworthy source of commercially important products and 70% of the known antibiotics are produced by actinobacteria, by the genus Streptomyces [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, Actinobacteria living in other niches, such as the marine environment (sea sediments, coral reefs, invertebrates, etc. ), have gained value because of their chemo-diversity [ 18 , 19 , 20 , 21 ] influenced by their complex environment with extreme variations in pressure, salinity, light, and temperature [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease—A Systematic Literature Review

2022

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Acne vulgaris is a multifactorial disease that remains under-explored; up to date it is known that the bacterium Cutibacterium acnes is involved in the disease occurrence, also associated with a microbial dysbiosis. Antibiotics have become a mainstay treatment generating the emergence of antibiotic-resistant bacteria. In addition, there are some reported side effects of alternative treatments, which indicate the need to investigate a different therapeutic approach. Natural products continue to be an excellent option, especially those extracted from actinobacteria, which represent a prominent source of metabolites with a wide range of biological activities, particularly the marine actinobacteria, which have been less studied than their terrestrial counterparts. Therefore, this systematic review aimed to identify and evaluate the potential anti-infective activity of metabolites isolated from marine actinobacteria strains against bacteria related to the development of acne vulgaris disease. It was found that there is a variety of compounds with anti-infective activity against Staphylococcus aureus and Staphylococcus epidermidis, bacteria closely related to acne vulgaris development; nevertheless, there is no report of a compound with antibacterial activity or quorum-sensing inhibition toward C. acnes, which is a surprising result. Since two of the most widely used antibiotics for the treatment of acne targeting C. acnes were obtained from actinobacteria of the genus Streptomyces, this demonstrates a great opportunity to pursue further studies in this field, considering the potential of marine actinobacteria to produce new anti-infective compounds.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease—A Systematic Literature Review

2022

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“…4-methoxyacetanilide (60) produced by marine Streptomyces sp. SCA29, was stated to inhibit α-glucosidase and α-amylase enzymes, and show antibacterial activity and cytotoxicity against various cancers, including HT-29 cell line ( Siddharth and Vittal, 2019 ). The chemical structure of compounds 31–60 are illustrated in Figure 2 .…”

Section: The Ecological Diversity Of Actinobacteria and Their Nps Aga...mentioning

confidence: 99%

Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review

et al. 2022

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Colorectal cancer (CRC) is a common, and deadly disease. Despite the improved knowledge on CRC heterogeneity and advances in the medical sciences, there is still an urgent need to cope with the challenges and side effects of common treatments for the disease. Natural products (NPs) have always been of interest for the development of new medicines. Actinobacteria are known to be prolific producers of a wide range of bioactive NPs, and scientific evidence highlights their important protective role against CRC. This review is a holistic picture on actinobacter-derived cytotoxic compounds against CRC that provides a good perspective for drug development and design in near future. This review also describes the chemical structure of 232 NPs presenting anti-CRC activity with the being majority of quinones, lactones, alkaloids, peptides, and glycosides. The study reveals that most of these NPs are derived from marine actinobacteria followed by terrestrial and endophytic actinobacteria, respectively. They are predominantly produced by Streptomyces, Micromonospors, Saliniospors and Actinomadura, respectively, in which Streptomyces, as the predominant contributor generating over 76% of compounds exclusively. Besides it provides a valuable snapshot of the chemical structure-activity relationship of compounds, highlighting the presence or absence of some specific atoms and chemical units in the structure of compounds can greatly influence their biological activities. To the best of our knowledge, this is the first comprehensive review on natural actinobacterial compounds affecting different types of CRC. Our study reveals that the high diversity of actinobacterial strains and their NPs derivatives, described here provides a new perspective and direction for the production of new anti-CRC drugs and paves the way to innovation for drugs discovery in the future. The knowledge obtain from this review can help us to understand the pivotal application of actinobacteria in future drugs development.

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“…SCA29 (India) had antibacterial activity against test bacterial pathogens, including MRSA ATCC NR-46171, and had other properties such as enzyme inhibitory and cytotoxic potentials. The spectral analyses led to the identification of an acetamide derivative, 4-methoxyacetanilide, as the bioactive compound [41]. An investigation by Yang et al to discover novel antibiotics against multidrug-resistant pathogen led to the isolation of S. lusitanus OUCT16-27 from Indian Ocean (4495 m depth), which produced new angucycline, new grincamycin L (1), and other known compounds (Figure 2A).…”

Section: Bacteria From Marine Sedimentsmentioning

confidence: 99%

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

et al. 2020

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As the search for new antibiotics continues, the resistance to known antimicrobial compounds continues to increase. Many researchers around the world, in response to antibiotics resistance, have continued to search for new antimicrobial compounds in different ecological niches such as the marine environment. Marine habitats are one of the known and promising sources for bioactive compounds with antimicrobial potentials against currently drug-resistant strains of pathogenic microorganisms. For more than a decade, numerous antimicrobial compounds have been discovered from marine environments, with many more antimicrobials still being discovered every year. So far, only very few compounds are in preclinical and clinical trials. Research in marine natural products has resulted in the isolation and identification of numerous diverse and novel chemical compounds with potency against even drug-resistant pathogens. Some of these compounds, which mainly came from marine bacteria and fungi, have been classified into alkaloids, lactones, phenols, quinones, tannins, terpenes, glycosides, halogenated, polyketides, xanthones, macrocycles, peptides, and fatty acids. All these are geared towards discovering and isolating unique compounds with therapeutic potential, especially against multidrug-resistant pathogenic microorganisms. In this review, we tried to summarize published articles from 2015 to 2019 on antimicrobial compounds isolated from marine sources, including some of their chemical structures and tests performed against drug-resistant pathogens.

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Isolation, characterization, and structural elucidation of 4-methoxyacetanilide from marine actinobacteria Streptomyces sp. SCA29 and evaluation of its enzyme inhibitory, antibacterial, and cytotoxic potential

Cited by 20 publications

References 22 publications

Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease—A Systematic Literature Review

Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease—A Systematic Literature Review

Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

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