Isolation, Characterization and Antianxiety Activity of Pentacosan-13-ol from <i>Ferula sumbul</i> Hook. Roots

Batra, Sonali; Kumar, Ashwani; Sharma, Anupam

doi:10.1080/22311866.2018.1472037

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…In addition to this, the doses of different extract/fractions administered to mice were selected proportionately based on the yield w.r.t. their mother extracts, as shown in Table 1 23 .…”

Section: Resultsmentioning

confidence: 99%

“…For mother extract i.e., hydromethanol extract, dose-response studies were performed at 100, 200, and 400 mg/kg. Doses of subsequent fraction(s) were determined proportionately based on the fraction w.r.t its mother fraction yield and are shown in Table 1 23 . Mice were euthanized 24 h after the HCl instillation for the analysis of anti-inflammatory activity using the following parameters:…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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2022

IJPSR

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Acute Lung Injury (ALI) and its more severe form Acute Respiratory Distress Syndrome (ARDS) is a clinical syndrome with a high mortality rate (27-41%). There is no pharmacological therapy for ALI treatment so far because of the complex mechanism and involvement of multiple pathways. So, the present study was designed to test the role of different extract/fractions of fruits of a traditional plant Randia dumetorum Lamk. utilizing a mouse model of acid aspiration (HCl) mediated ALI. Hydromethanolic extract (HME) was screened for anti-inflammatory activity at 100, 200, and 400mg/kg doses employing total and differential cell count in bronchoalveolar lavage fluid. Our data demonstrated that oral administration of HME in mice before induction of ALI resulted in reducing the number of BALF inflammatory cells, particularly neutrophils, in a dose-dependent manner. Further, HME was partitioned into ethyl acetate soluble (EASF) and ethyl acetate insoluble fraction (EAISF) to extract phytoconstituents based on differential polarity. Our data revealed that EAISF showed better efficacy than EASF for the amelioration of lung inflammation. Similarly, bioactive EAISF was partitioned into ethanol-soluble (ESF) and ethanol insoluble fraction (EISF), where ESF had more potent anti-inflammatory activity in mice w.r.t. EISF as depicted by the number of total cells and neutrophils in the lungs of mice. Overall, our results validate the traditional use of Randia dumetorum fruits in managing respiratory ailments, and further fractionation/investigation of ESF is encouraged to unveil the bioactive ingredient possessing anti-inflammatory potential.INTRODUCTION: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are two terms used interchangeably to depict pulmonary inflammation. ALI/ARDS can be triggered by direct (pneumonia, aspiration of gastric contents, pulmonary contusion, neardrowning, inhalation injury, reperfusion pulmonary edema, etc.) or indirect means (sepsis, multiple traumas, acute pancreatitis, cardiopulmonary bypass, transfusion of blood QUICK RESPONSE CODE

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“…In addition to this, the doses of different extract/fractions administered to mice were selected proportionately based on the yield w.r.t. their mother extracts, as shown in Table 1 23 .…”

Section: Resultsmentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Untitled

2022

IJPSR

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“…These are the important processes of non‐rapid eye movement (REM) sleep, thus these flavonoids and related biomolecules influence sleep patterns and anxiety processes (Nami et al, 2020 ). Certain plant‐based bioactive compounds like valerenic acid, mahanimbine, and coumarins have sedative, anxiolytic, and antidepressant activities (Batra et al, 2018 ; Jung et al, 2015 ; Sharma et al, 2017 ). Studies have shown that valerenic acid has benzodiazepine‐like tranquilizing activity which acts by increasing the levels of gamma‐aminobutyric acid (GABA).…”

Section: Nutraceuticals and The Management Of Covidmentioning

confidence: 99%

Nutraceuticals and COVID‐19: A mechanistic approach toward attenuating the disease complications

Paudel

Patel

Vishwas

et al. 2022

Journal of Food Biochemistry

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Nutraceuticals have emerged as potential compounds to attenuate the COVID‐19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a large scale, in almost every household due to their better affordability and easy access. Therefore, current research is focused on developing newer advanced formulations from potential drug candidates including nutraceuticals with desirable properties viz, affordability, ease of availability, ease of administration, stability under room temperature, and potentially longer shelf‐lives. As such, various nutraceutical‐based products such as compounds could be promising agents for effectively managing COVID‐19 symptoms and complications. Most importantly, regular consumption of such nutraceuticals has been shown to boost the immune system and prevent viral infections. Nutraceuticals such as vitamins, amino acids, flavonoids like curcumin, and probiotics have been studied for their role in the prevention of COVID‐19 symptoms such as fever, pain, malaise, and dry cough. In this review, we have critically reviewed the potential of various nutraceutical‐based therapeutics for the management of COVID‐19. We searched the information relevant to our topic from search engines such as PubMed and Scopus using COVID‐19, nutraceuticals, probiotics, and vitamins as a keyword. Any scientific literature published in a language other than English was excluded. Practical applications Nutraceuticals possess both nutritional values and medicinal properties. They can aid in the prevention and treatment of diseases, as well as promote physical health and the immune system, normalizing body functions, and improving longevity. Recently, nutraceuticals such as probiotics, vitamins, polyunsaturated fatty acids, trace minerals, and medicinal plants have attracted considerable attention and are widely regarded as potential alternatives to current therapeutic options for the effective management of various diseases, including COVID‐19.

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