Isolation and X-ray Structure of Deoxycholic Acid from the Sponge Ircinia sp

Abstract

Ethyl acetate extract of the sponge Ircinia sp., collected by SCUBA divers off the coast of southern India, contained a cholest-based sterol of insignificant antimicrobial activity, with one carboxylic acid side chain (3α, 7β-dihydroxy-5β-cholan-24-oic acid, DCA). The structure of the compound was determined by spectroscopic data and single crystal X-ray diffraction studies. DCA crystallizes in the tetragonal space group P4 1 2 1 2, chirality documented by solution optical rotation [α] D = +67.4º (c 0.16, CHCl 3).

Isolation of acetylated bile acids from the sponge Siphonochalina fortis and DNA damage evaluation by the comet assay

“…Such is the case of an epidioxy sterol as an antifouling substance from Lendenfeldia chondrodes [25], the isolation of deoxycholic acid from Ircinia sp. [26] and bile acid derivatives from a sponge-associated bacterium Psychrobacter sp. that showed antibacterial activity [27].…”