Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar Rain Forest

Abstract

Investigation of the endemic Madagascan plant Sterculia tavia Baill (Malvaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two new bioactive calamenene-type sesquiterpenoids, named tavinin A (2) and epi-tavinin A (3) together with the known sesquiterpenoid mansonone G (1). The structures of the two new compounds were elucidated based on analysis of their 1D and 2D NMR spectra and mass spectrometric data, and were confirmed by de novo synthesis. The three isolated sesquiterpenoids (1–3) had modest antiproliferative activities against the A2780 ovarian cancer cell line, with IC50 values of 10.2, 5.5 and 6.7 µM, respectively.

Antioxidant Capacity of Some Selected Medicinal Plants in East Nusa Tenggara, Indonesia: The Potential of Sterculia quadrifida R.Br.

“…Study of genus Sterculia plant extracts revealed some biological activity like anti-diabetic from S. villosa, 5 anti-inflammatory and antifertility activity from S. foetida, 33 larvacidal activity from S. guttata, 34 and anti-proliferative activity from S. tavia. 35 Some chemical constituents also reported from genus Sterculia plants such as sitosterol and betulinic acid were isolate from S. striata, 36 sterculinine I and II were isolate from S. lychnophora, 37 and 1,6-diferuloyl glucose was isolate from S. foetida.…”

Anti-infective Properties of Brachychiton rupestris and Brachychiton luridum Leaves and their Qualitative Phytochemical Screening

“…Malvaceae is a family of flowering plants with more than 200 genera and nearly 2300 species [6,7]. The family is composed mainly of tropical trees and shrubs with a few climbing and herbaceous species showing a wide array of medicinal values [6][7][8].…”

“…The family is composed mainly of tropical trees and shrubs with a few climbing and herbaceous species showing a wide array of medicinal values [6][7][8]. Brachychiton is a small genus belonging to family Malvaceae with approximately 30 species; native to Australia [9].…”

SterculiaandBrachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery

“…[4] Sterculia species are rich in alkaloids, saponins and flavonoid glycosides, which showed a wide array of biological activities such as antimicrobial, antifungal, insecticidal, cytotoxic, antioxidant and anti-inflammatory activities. [2,5] Apart from the pharmacological activities of its secondary metabolites, there is also a myriad of pharmaceutical applications of its natural gums derived from its trees exudates, such as gum karaya (S. urens) and chicha gum (S. striata). These gummy exudates are used as stabilizers, disintegrators and active ingredient release enhancers.…”

“…Species from this family were subjected to intensive investigation due to the presence of different secondary metabolites with potent biological activity, such as triterpenes, flavonoids, alkaloids and coumarins. [2,3] Among the pharmacologically interesting genera are Sterculia and Brachychiton. They are related genera which were previously placed in the family Sterculiaceae.…”