Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.

Anuradha, V.; Srinivas, P.; Rao, R. Ranga; Manjulatha, K.; Purohit, M. G.; Rao, J. Madhusudana

doi:10.1016/j.bmc.2006.06.048

Cited by 41 publications

(25 citation statements)

References 12 publications

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“…The summary of the 1 and 2D results of compound 8A established and characterized the structure of 8A as trimethoxy lophirone A (Figure 1), which is, to our knowledge, a new compound. Tri-methoxy lophirone A is a derivative of known compounds: lophirone A (Ghogomu et al, 1987;Messanga et al, 2001;Pegnyemb, 2003;Anuradha et al, 2006), calodenone (Messanga et al, 1992;Pegnyemb et al, 2003;Likhitwiyawuid et al, 2005;Anuradha et al, 2006) and afzelone D (Pegnyemb et al, 2003). The difference between Compound 8A (trimethoxy lophirone A) and the three known compounds, being the presence of 3-methoxy groups in 8A instead of none, one and two methoxy groups in lophirone A, calodenone and afzelone D, respectively (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Ochna schweinfurthiana F Hoffm is a shrub or small tree up to 4 m tall that belongs to the family Ochnaceae. The family has been reported to be a rich source of complex dimmers of biflavonoids and chalcones (Anuradha et al, 2006;Ichino et al, 2006;Jayaprakasam et al, 2000;Kaewamatawong et al, 2002). We have previously reported the anti-microbial effect of the methanol and acetone extracts of the stem bark and leaves extract of the O. schweinfurthiana (Abdullahi et al, 2010) and also isolated and investigated the anti-microbial activity of a flavonoid di-glycoside from the butanol soluble fraction of methanolic leaves extract of O. schweinfurthiana (Abdullahi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Isolation and characterization of an anti-microbial biflavonoid from the chloroform-soluble fraction of methanolic root extract of Ochna schweinfurthiana (Ochnaceae)

Abdullahi¹,

Musa²,

Haruna³

et al. 2014

Afr. J. Pharm. Pharmacol.

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The chromatographic investigation of the chloroform soluble fraction of methanolic root extract of Ochna schweinfurthiana using a combination of silica and sephadex LH-20 led to the isolation of trimethoxy derivative of lophirone A. The structure of this new compound was determined using both 1 and 2D nuclear magnetic resonance (NMR). The antimicrobial activity of the isolated compound was also investigated using agar diffusion and broth dilution techniques. Clinical isolates obtained from the

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of an anti-microbial biflavonoid from the chloroform-soluble fraction of methanolic root extract of Ochna schweinfurthiana (Ochnaceae)

Abdullahi¹,

Musa²,

Haruna³

et al. 2014

Afr. J. Pharm. Pharmacol.

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“…Previous studies had reported the anti-inflammatory activity of the non-polar solvent extracts from various plants species. For example, ethyl acetate fraction of Ochna squarrosa L. showed a higher anti-inflammatory activity when compared to diclofenac sodium [ 15 ]. Another report showed that the anti-inflammatory activity of the hexane extract of Alchornea cordifolia was better than indomethacin in an in vivo study [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Elucidation of in-vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root

Othman

Abdullah

Ahmad

et al. 2015

BMC Complement Altern Med

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BackgroundThe Jatropha curcas plant or locally known as “Pokok Jarak” has been widely used in traditional medical applications. This plant is used to treat various conditions such as arthritis, gout, jaundice, wound and inflammation. However, the nature of compounds involved has not been well documented. Hence, this study was conducted to investigate the anti-inflammatory activity of different parts of J. curcas plant and to identify the active compounds involved.MethodsIn this study, methanol (80%) extraction of four different parts (leaves, fruits, stem and root) of J. curcas plant was carried out. Phenolic content of each part was determined by using Folin-Ciocalteau reagent. Gallic acid was used as the phenol standard. Each plant part was screened for anti-inflammatory activity using cultured macrophage RAW 264.7 cells. The active plant part was then partitioned with hexane, chloroform, ethyl acetate and water. Each partition was again screened for anti-inflammatory activity. The active partition was then fractionated using an open column chromatography system. Single spots isolated from column chromatography were assayed for anti-inflammatory and cytotoxicity activities. Spots that showed activity were subjected to gas chromatography mass spectrophotometry (GC-MS) analysis for identification of active metabolites.ResultsThe hexane partition from root extract showed the highest anti-inflammatory activity. However, it also showed high cytotoxicity towards RAW 264.7 cells at 1 mg/mL. Fractionation process using column chromatography showed five spots. Two spots labeled as H-4 and H-5 possessed anti-inflammatory activity, without cytotoxicity activity. Analysis of both spots by GC-MS showed the presence of hexadecanoic acid methyl ester, octadecanoic acid methyl ester and octadecanoic acid.ConclusionThis finding suggests that hexadecanoic acid methyl ester, octadecanoic acid methyl ester and octadecanoic acid could be responsible for the anti-inflammatory activity of the J. curcas root extract.

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“…Chalcones, 1,3-diphenyl-1-propan-3-one derivatives, have a wide range of biological properties, including anticancer (Achanta et al, 2006;Kim, Choi et al, 2006), antiproliferative (Hsu et al, 2006), antimalarial (Wirasathien et al, 2006), antiinflammatory (Anuradha et al, 2006), anti-allergic (Daikonya et al, 2004) and antagonist . Chalcones exhibit inhibitory activity against nitric oxide production (Han et al, 2006), dengue 2 virus NS3 protease (Kiat et al, 2006) and tyrosinase (Khatib et al, 2005).…”

Section: Commentmentioning

confidence: 99%

3-(3-Bromophenyl)-1-(2-naphthyl)prop-2-en-1-one

Moorthi¹,

Chinnakali

Nanjundan

et al. 2007

Acta Cryst E

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Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.

Cited by 41 publications

References 12 publications

Isolation and characterization of an anti-microbial biflavonoid from the chloroform-soluble fraction of methanolic root extract of Ochna schweinfurthiana (Ochnaceae)

Isolation and characterization of an anti-microbial biflavonoid from the chloroform-soluble fraction of methanolic root extract of Ochna schweinfurthiana (Ochnaceae)

Elucidation of in-vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root

3-(3-Bromophenyl)-1-(2-naphthyl)prop-2-en-1-one

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