Isolation and structure determination of oxidative degradation products of atorvastatin

Kračun, Matjaž; Kocijan, Andrej; Bastarda, Andrej; Grahek, Rok; Plavec, Janez; Kocjan, Darko

doi:10.1016/j.jpba.2009.06.008

Cited by 24 publications

(15 citation statements)

References 28 publications

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“…Six unknown atorvastatin degradation products formed under stress conditions of hydrolysis, oxidation and photolysis were identified. Preparative HPLC method with Luna prep C18 (2) column (200 mm x 50 mm, 10 μm) was used for isolation of four oxidative degradation products [42]. HPLC coupled to MS, high resolution MS and NMR spectroscopy were applied for the structure elucidation.…”

Section: Atorvastatinmentioning

confidence: 99%

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

Nigović¹,

Mornar²,

Sertić³

2012

Chromatography - The Most Versatile Method of Chemical Analysis

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Section: Atorvastatinmentioning

confidence: 99%

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

Nigović¹,

Mornar²,

Sertić³

2012

Chromatography - The Most Versatile Method of Chemical Analysis

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“…Preparative HPLC (Kračun et al, 2009;Grahek et al, 2006) needed to apply twice the purification with chromatography using buffers and also freeze drying. The isolation with SFC has several advantages over HPLC: isolation in only one step and better chromatographic purity.…”

Section: Isolaton Of Impuritiesmentioning

confidence: 99%

“…In the European Pharmacopoeia and United States Pharmacopeia and in the primary literature (Kračun et al, 2009;Grahek et al, 2006;Shah et al, 2008;Lee et al, 2008), over 35 impurities of atorvastatin are mentioned. Some publications (Lee et al, 2008) deal with byproducts that are formed during the process of synthesis of atorvastatin.…”

Section: Introductionmentioning

confidence: 99%

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Isolation of oxidative degradation products of atorvastatin with supercritical fluid chromatography

Klobčar

Prosen

2015

Biomedical Chromatography

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The isolation of four oxidative degradation products of atorvastatin using preparative high-performance liquid chromatography applying at least two chromatographic steps is known from the literature. In this paper it is shown that the same four impurities could be isolated from similarly prepared mixtures in only one step using supercritical fluid chromatography. The methods for separation were developed and optimized. The preparation of the mixtures was altered in such a way as to enhance the concentration of desired impurities. Appropriate solvents were applied for collection of separated impurities in order to prevent degradation. The structures of the isolated impurities were confirmed and their purity determined. The preparative supercritical fluid chromatography has proven to be superior to preparative HPLC regarding achieved purity of standards applying fewer chromatographic as well as isolation steps.

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“…Different analytical methods have been carried out the determination of AT in pharmaceutical samples or biological fluids including highperformance liquid chromatography [1][2][3][4][5][6][7] , capillary electrophoresis techniques 8 , spectrophotometry 9,10 and electrochemical methods [11][12][13][14][15] . Electrochemical stripping methods carried out by the deposition with the preconcentration of an analyte onto the working electrode surface are one of the most suitable methods for the determination of several pharmaceutical compounds.…”

mentioning

confidence: 99%

Electrochemical oxidation of atorvastatin and its adsorptive stripping determination in pharmaceutical dosage forms and biological fluids

Eskiköy

Durmuș

Kılıç

2011

Collect. Czech. Chem. Commun.

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Electrochemical behavior of atorvastatin (AT) and optimum conditions to its quantitative determination were investigated using voltammetric methods. Some electrochemical parameters such as diffusion coefficient, surface coverage of adsorbed molecules, electron transfer coefficient, standard rate constant and number of electrons were calculated using the results of cyclic voltammetry. A tentative mechanism for the oxidation for AT has been suggested. The oxidation signal of AT molecule was used to develop fully validated, new, rapid, selective and simple square-wave anodic adsorptive stripping voltammetric (AdsSWV) and differential pulse anodic stripping voltammetric (AdsDPV) methods to direct determination of AT in pharmaceutical dosage forms and biological samples. For the AdsDPV and AdsSWV techniques, linear working ranges were found to be 1.0 × 10 -7 -5.0 × 10 -6 and 3.0 × 10 -7 -5.0 × 10 -6 mol l -1 , respectively. The detection limits obtained from AdsDPV and AdsSWV were calculated to be 6.55 × 10 -8 and 1.53 × 10 -7 mol l -1 , respectively. The methods were successfully applied to assay the drug in tablets, human blood serum and human urine.

show abstract

Isolation and structure determination of oxidative degradation products of atorvastatin

Cited by 24 publications

References 28 publications

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

Isolation of oxidative degradation products of atorvastatin with supercritical fluid chromatography

Electrochemical oxidation of atorvastatin and its adsorptive stripping determination in pharmaceutical dosage forms and biological fluids

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