Isolation and redefinition of the toxic agent from cocklebur (Xanthium strumarium)

Cole, Richard; Stuart, Barry P.; Lansden, John A.; Cox, Richard H.

doi:10.1021/jf60232a043

Cited by 63 publications

(60 citation statements)

References 5 publications

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“…In the present study, the major component of the essential oil was found to be β-caryophyllene (17.53%), which did not agree with the previous results in which β-guaiene [27,28] and limonene [29][30][31] were reported to be the major components. It is interesting to note that β-guaiene, which had been reported as major constituent of leaves oil [27,28] was found to be absent in this study.…”

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confidence: 99%

Chemical Composition and Antifungal Activity of Essential Oil from Xanthium strumarium L. Leaves

Parveen¹,

Mazhar²,

Siddique³

et al. 2017

Journal of Pharmaceutical Sciences

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Parveen, et al.: Studies on Essential Oil of Xanthium strumarium L. LeavesThe hydrodistilled essential oil from Xanthium strumarium L. leaves was analysed by gas chromatographymass spectrometry. Nine out of twenty two constituents were identified from X. strumarium oil. The main components of the oil were β-caryophyllene (17.53%), α-cadinol (6.66%), spathulenol (6.09%), limonene (5.66%) and 1,3,5-trimethyl-2[2-nitroallyl]benzene (3.29%). Phytol (2.42%), α-muurolene (2.08%), copaene (1.47%) were present in appreciable amounts. E,E,Z-1,3,12-nonadecatriene-5,14-diol (0.27%) was present in minor amount. The oil displayed high degree of antifungal effect against all fungal strains with 11.8-46.0 mm zone of inhibition at concentration range 8-250 μg/ml. The 8 μg/ml minimum fungicidal concentration along with being the minimum inhibitory concentration points to the potential of X. strumarium essential oil as a promising source of antifungal agents with useful biomedical applications.

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confidence: 99%

Chemical Composition and Antifungal Activity of Essential Oil from Xanthium strumarium L. Leaves

Parveen¹,

Mazhar²,

Siddique³

et al. 2017

Journal of Pharmaceutical Sciences

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“…The results showed that the consumption of the fruits (burrs) induced hepatic necrosis, as well as myocardial injury in humans. The toxic substance of X. strumarium was isolated and identified as carboxyatractyloside (CAT) (Cole et al, 1980), a highly selective inhibitor of oxidative phosphorylation (Scott et al, 1993). The presence of CAT in the adult leaves, cotyledonary stages, seeds (inside the burr), and the shell of the burr was investigated via ESI-MS/ MS, and the CAT was found in the extracts from the seed and plants in the cotyledonary stage, but not in the adult leaves or shell of burr, so the medicinal use of X. strumarium should be restricted to the adult leaves .…”

Section: Introductionmentioning

confidence: 99%

Effects of extraction methods of phenolic compounds from Xanthium strumarium L. and their antioxidant activity

Scherer

Godoy

2014

Rev. bras. plantas med.

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Recebido para publicação em 09/11/2011 Aceito para publicação em 04/06/2013 RESUMO: Foram avaliados os efeitos de métodos de extração e de solventes sobre o rendimento de extrato, conteúdo de fenólicos totais, atividade antioxidante, e composição dos compostos fenólicos de Xanthium strumarium L. A atividade antioxidante foi determinada pelo método do radical 2,2-difenil-1-picrilhidrazila (DPPH), e a composição dos compostos fenólicos foi determinada por cromatografia líquida de alta eficiência e por espectrometria de massas com ionização por electrospray. Todos os resultados foram afetados pelo método de extração e, principalmente pelo solvente utilizado, sendo que os melhores resultados foram obtidos com o solvente metanol. Os extratos metanólico e etanólico apresentaram forte ação antioxidante e os principais compostos fenólicos encontrados nos extratos foram os ácidos ferúlico e clorogênico. Palavras-chave:Xanthium strumarium, carrapicho, atividade antioxidante, compostos fenólicos, IAA ABSTRACT: Efeito de métodos de extração de compostos fenólicos de Xanthium strumarium L. e suas atividades antioxidantes. The effect of extraction methods and solvents on overall yield, total phenolic content, antioxidant activity, and the composition of the phenolic compounds in Xanthium strumarium extracts were studied. The antioxidant activity was determined by using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), and the composition of the phenolic compounds was determined by HPLC-DAD and LC/MS. All results were affected by the extraction method, especially by the solvent used, and the best results were obtained with the methanol extract. The methanolic and ethanolic extracts exhibited strong antioxidant activity, and the chlorogenic and ferulic acids were the most abundant phenolic compounds in the extracts.

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“…O achado histopatológico mais significativo é a lesão hepática tóxica clássica de necrose coagulativa centrolobular acompanhada de congestão e hemorragias (Martin et al 1986). O princípio ativo de Xanthium spp é o glicosideo carboxiatractilosídeo (CAT) (Cole et al 1980, Stuart et al 1981, Calanasan et al 1985.…”

Section: Introductionunclassified

Intoxicação experimental pelos frutos de Xanthium cavanillesii (Asteraceae) em ovinos

et al. 1999

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Os frutos moídos de Xanthium cavanillesii foram administrados por via oral, em doses únicas ou fracionadas, a 15 ovinos adultos. Nove ovinos morreram. Doses a partir de 2 g/kg em uma única administração foram letais para os ovinos. Doses únicas de 1,25 g/kg e doses de 2,5 g/kg subdivididas em duas administrações diárias (1,25 g/kg em dois dias consecutivos) não causaram a intoxicação. Sinais clínicos foram observados apenas nos animais que morreram. Iniciavam entre 5 horas e 20 horas após o início da administração dos frutos. A evolução do quadro clínico foi superaguda (90 minutos a 3 horas) ou aguda (9 a 13 horas). Sinais clínicos incluíam apatia, anorexia, hipomotilidade ruminal, tremores musculares generalizados, incoordenação motora, andar rígido, relutância em caminhar, instabilidade, quedas e decúbito. Muitos animais apresentavam corrimento nasal seromucoso que dificultava a respiração. Nas fases terminais havia tiques, sialorréia, convulsões, nistagmo, movimentos de pedalagem e períodos de apnéia seguidos de morte. Os principais achados de necropsia incluíam acentuação do padrão lobular do fígado acompanhada de petéquias distribuídas aleatoriamente na superfície capsular e de corte, distensão da vesícula biliar associada a edema e hemorragias na parede, ascite, hidrotórax, edema gelatinoso e translúcido da região perirrenal, conteúdo do ceco e alça proximal do cólon ascendente ressequido, compactado, recoberto por muco e estrias de sangue coagulado. Havia petéquias e sufusões disseminadas. A principal lesão microscópica consistia em acentuada necrose coagulativa hepatocelular centrolobular ou massiva acompanhada de congestão e hemorragia e vacuolização ou tumefação dos hepatócitos remanescentes.

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Isolation and redefinition of the toxic agent from cocklebur (Xanthium strumarium)

Cited by 63 publications

References 5 publications

Chemical Composition and Antifungal Activity of Essential Oil from Xanthium strumarium L. Leaves

Chemical Composition and Antifungal Activity of Essential Oil from Xanthium strumarium L. Leaves

Effects of extraction methods of phenolic compounds from Xanthium strumarium L. and their antioxidant activity

Intoxicação experimental pelos frutos de Xanthium cavanillesii (Asteraceae) em ovinos

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