1999
DOI: 10.1002/(sici)1521-4028(199912)39:5/6<325::aid-jobm325>3.0.co;2-s
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Isolation and partial characterization of Bac201: A plasmid-associated bacteriocin-like inhibitory substance fromStaphylococcus aureus AB201

Abstract: Staphylococcus aureus AB201, a clinical isolate from wound pus, produced a bacteriocin‐like inhibitory substance termed as Bac201 that exhibited a broad‐spectrum activity against both gram‐positive as well as gram‐negative bacteria. Among gram‐negative bacteria it was active against Neisseria meningitidis and Acinetobacter calcoaceticus both being gram‐negative cocci. Inhibition due to the effect of organic acids, hydrogen peroxide, or bacteriophages was excluded. This inhibitory substance could not be induced… Show more

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Cited by 12 publications
(9 citation statements)
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“…The six peaks were collected separately during GF-HPLC and activity of each peak was checked. The target organism was Staphylococcus aureus Neisseria meningitidis and Acinetobacter calcoaceticus, both being clinically significant gram-negative cocci has already been described (IQBAL et al 1999). The data also demonstrate that Staphylococcus aureus AB201, in addition to possessing Bac201 activity, has the immunity factors necessary to protect itself from its own lethal effects (Fig.…”
Section: Inhibitory Spectrummentioning
confidence: 59%
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“…The six peaks were collected separately during GF-HPLC and activity of each peak was checked. The target organism was Staphylococcus aureus Neisseria meningitidis and Acinetobacter calcoaceticus, both being clinically significant gram-negative cocci has already been described (IQBAL et al 1999). The data also demonstrate that Staphylococcus aureus AB201, in addition to possessing Bac201 activity, has the immunity factors necessary to protect itself from its own lethal effects (Fig.…”
Section: Inhibitory Spectrummentioning
confidence: 59%
“…The bacteriocin activity is present in the supernatant, as it could not be eluted, should it be associated with cell membrane. The bacteriocin-like activity was not due to viruses, organic acids or hydrogen peroxide (IQBAL et al 1999). Bac201 was purified by ammonium sulfate precipitation followed by gel-filtration and reversed-phase high performance liquid chromatography.…”
Section: Discussionmentioning
confidence: 99%
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“…Bac201 was tested for sensitivity to pH, heat and various enzymes (Table 2). Bac201 could conclusively be classified as heat stable, since full biological activity was retained after heating at 100 GC for 15 min (IQBAL et al 1999). However, purified Bac201 activity was rapidly inactivated at autoclaving temperature (121 GC for 15 min).…”
Section: Physical and Chemical Propertiesmentioning
confidence: 99%