Isolation and Identification of the Phenolic Compounds from the Roots of Sanguisorba officinalis L. and Their Antioxidant Activities

Abstract

Four phenolic compounds were isolated from the roots of Sanguisorba officinalis L. by silica gel column chromatography and preparative HPLC. On the basis of chemical and spectroscopic methods, their structures were identified as methyl 4-O-β-D-glucopyranosy-5-hydroxy-3-methoxylbenzoate (1), 3,3′,4′-tri-O-methylellagic acid (2), fisetinidol-(4α-8)-catechin (3), and (+)-catechin (4). Compound 1 is a new phenolic glycoside and compounds 2 and 3 were isolated from the Sanguisorba genus for the first time. Compounds 1–4 were also assayed for their antioxidant activities using the DPPH free radical assay.

Ziyuglycoside II-induced apoptosis in human gastric carcinoma BGC-823 cells by regulating Bax/Bcl-2 expression and activating caspase-3 pathway

“…The dried root of Sanguisorba officinalis L., a plant that is widely distributed throughout China, Japan, and Korea, has been used to treat inflammatory and metabolic diseases for centuries (10, 11). Recently, compounds exacted from this plant have been reported to exhibit anticancer activity (12- 14).…”

Extracts of the medicinal herb Sanguisorba officinalis inhibit the entry of human immunodeficiency virus-1

“…It is easily found in northern regions of China and has been used as a TCM for thousands of years to treat hemostasis and inflammation [11]. Some other functions that have been discovered in recent years include its antioxidant and anti-tumor properties [12–14].…”

Antiangiogenic Effects of Ziyuglycoside II, a Major Active Compound of Sanguisorba officinalis L.

“…Sanguisorba officinalis L. grows naturally in Korea, China, Japan, Siberia, and Europe. It possesses a variety of pharmacological properties including antioxidant (Zhang et al ., ), antitumor (Choi et al ., ; Shin et al ., ), antiangiogenic (Wang et al ., ), and immunomodulatory effects (Cai et al ., ; Liang et al ., ). In addition, a variety of chemical constituents have been isolated from S. officinalis , and their biological properties have been evaluated (Tong et al ., ).…”