Isolation and identification of piceatannol as a phytoalexin from sugarcane

Brinker, Anita; Seigler, David S.

doi:10.1016/0031-9422(91)83181-j

Cited by 54 publications

(29 citation statements)

References 28 publications

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“…1) is a naturally occurring stilbene present in the skins of grape, rhubarb and sugar cane (Cantos et al, 2002;Waffo-Teguo et al, 2001;Brinker and Seigler, 1991;Matsuda et al, 2001). Piceatannol is a promising chemopreventative agent with anti-leukemic activity and is being extensively studied in various cancers including colorectal and lung cancer as well as in cardiovascular disease (Wolter et al, 2002;Kimura et al, 2000).…”

Section: Piceatannolmentioning

confidence: 96%

Determination of piceatannol in rat serum and liver microsomes: pharmacokinetics and phase I and II biotransformation

Roupe

Teng

et al. 2004

Biomedical Chromatography

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A method of analysis of piceatannol in biological fluids is necessary to study the kinetics of in vitro and in vivo metabolism and determine its concentration in foodstuffs. A novel and simple high-performance liquid chromatographic method was developed for simultaneous determination of piceatannol and products of its metabolism in rat serum and liver microsomes. Serum, or microsomes (0.1 mL), were precipitated with acetonitrile after addition of the internal standard, 4-methylumbelliferone. Separation was achieved on a phenomenex C(18) column (250 x 4.6 mm i.d., 5 microm) equipped with a phenomenex C(18) (4 x 3.0 mm i.d., 5 microm) guardcolumn with fluorescence excitation at 320 nm and emission at 420 nm. Separation was also possible with UV detection at 310 nm. The fluorescent calibration curves were linear ranging from 0.05 to 100 microg/mL. The mean extraction efficiency was >95%. Precision of the assay was <10% (coefficient of variation), and was within 10% at the limit of quantitation (0.05 ng/mL). Bias of the assay was lower than 7%. The limit of detection was 50 ng/mL for a 0.1 mL sample. The assay was applied successfully to the in vitro kinetic study of metabolism of piceatannol in rat liver microsomes and pharmacokinetics in rats. Three metabolites of piceatannol have been identified. .

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Section: Piceatannolmentioning

confidence: 96%

Determination of piceatannol in rat serum and liver microsomes: pharmacokinetics and phase I and II biotransformation

Roupe

Teng

et al. 2004

Biomedical Chromatography

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“…1A) is a naturally occurring stilbene present in the wood pulp of pine and eucalyptus trees, and is present in tea oils and herbal remedies [1][2][3][4]. The biological function of pinosylvin in trees is to protect the tree against severe biotic stress.…”

Section: Introductionmentioning

confidence: 99%

Determination and assay validation of pinosylvin in rat serum: application to drug metabolism and pharmacokinetics

Roupe

Halls

Davies

2005

Journal of Pharmaceutical and Biomedical Analysis

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“…Previously two novel bioactive 8-lactones, majorynolide (49, NSC 644647) and majorenolide (50, NSC 644648), were isolated from the bark extracts of this Brazilian avocado species(101). Now a third compound, majoranolide(51) has been isolated (102); the absolute stereochemistry at C5 was predicted by Horeau's method and cd studies. Isolate 51 was quite bioactive but not selective; 50 was quite insecticidal against melon aphids (80% mortality at 10 ppm) at Dow Elanco.…”

mentioning

confidence: 98%

Simple Bench-Top Bioassays (Brine Shrimp and Potato Discs) for the Discovery of Plant Antitumor Compounds

McLaughlin

Chang

Smith

1993

ACS Symposium Series

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Advances in separation technology and spectral methodology have greatly simplified the science of phytochemistry. New challenges lie in the isolation of nature's trace phytochemicals which exert various bioactivities and, thus, present potential usefulness to mankind. To help meet these challenges in discovering novel plant antitumor compounds, we have developed two simple bench-top bioassays which conveniently expedite screening and activity-directed fractionation of active plant extracts. These are lethality to brine shrimp and the inhibition of crown gall tumors on discs of potato tubers. Progress in this laboratory over the past three years is reviewed here. Our most exciting leads are the Annonaceous acetogenins of which bullatacin offers the best potential for antitumor drug development; the potent pesticidal effects of these new agents, which act via mitochondrial inhibition, also offer economic potential.In 1992, about 1,130,000 people in the United States were diagnosed as having cancer (excluding skin cancers); also during this year about 520,000 people (1,400 people/day) in the U.S. died of cancer; there has been a steady rise in our cancer mortality rate in the last half-century in spite of the fact that 51% of the cancer patients (excluding those with skin cancer), through medical and chemotherapeutic intervention, can now expect to survive with their disease for at least five years following diagnosis (7). Thus, the search for new anticancer agents, especially those effective against breast, prostate, ovarian, and cervical cancers, has been given a top priority at the National Cancer Institute (NCI) (Broder, S.; letter to NIH grantees, December 12,1991).To help in this search, NCI has, from 1957 through 1991, screened, for antitumor activities, more than 156,000 plant extracts from over 53,000 plant species (2,3; McCloud, T.G., NCI/FCRF personal communication, 1992). Through the combination of efforts at NCI and various pharmaceutical companies, several chemically useful antitumor drugs have been developed and are marketed from the Catharanthus alkaloids and the lignans of Podophyllum species (4, 5). Current hopes are high that camptothecin and/or its analogues (6) and taxol and/or its congeners (7,8) will also survive the rigors of clinical testing and become routinely 0097-6156/93A)534-0112$07.50/0

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Isolation and identification of piceatannol as a phytoalexin from sugarcane

Cited by 54 publications

References 28 publications

Determination of piceatannol in rat serum and liver microsomes: pharmacokinetics and phase I and II biotransformation

Determination of piceatannol in rat serum and liver microsomes: pharmacokinetics and phase I and II biotransformation

Determination and assay validation of pinosylvin in rat serum: application to drug metabolism and pharmacokinetics

Simple Bench-Top Bioassays (Brine Shrimp and Potato Discs) for the Discovery of Plant Antitumor Compounds

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