Isolation and identification of oral Candida species in potentially malignant disorder and oral squamous cell carcinoma

Arya, Chandra Prakash; Jaiswal, Rakesh; Tandon, Aanchal; Jain, Amol

doi:10.4103/njms.njms_80_19

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…based on colony color and morphology. These investigations have consistently reported a higher carriage of C. albicans among subjects with OSCC compared to healthy subjects [28,29,31,44,59,60]. In contrast, using different methodologies such as PAS staining (38) and CFW fluorescence staining [39], or CHROMagar [61] and some sort of growth medium [62], others did not report a direct causative relationship between C. albicans and OSCC or epithelial dysplasia.…”

Section: Discussionmentioning

confidence: 99%

Real-Time PCR Detection of Candida Species in Biopsy Samples from Non-Smokers with Oral Dysplasia and Oral Squamous Cell Cancer: A Retrospective Archive Study

İlhan,

Vural,

Gürhan

et al. 2023

Cancers

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The impact of Candida sp. in the development of oral cancer remains uncertain and requires sensitive analytical approaches for clarification. Given the invasive capabilities of these microorganisms in penetrating and invading host tissues through hyphal invasion, this study sought to detect the presence of five Candida sp. in oral biopsy tissue samples from non-smoker patients. Samples were obtained from patients at varying stages of oral carcinogenesis, including dysplasia, carcinoma in situ, OSCC, and histologically benign lesions, and analyzed using Real-Time PCR. Oral tissue samples from 80 patients (46 males and 34 females) were included. Significantly higher C. albicans presence was detected in the mild/moderate dysplasia group compared to the healthy (p = 0.001), carcinoma in situ (p = 0.031) and OSCC groups (p = 0.000). Similarly, C. tropicalis carriage was higher in tissues with mild/moderate dysplasia compared to healthy (p = 0.004) and carcinoma in situ (p = 0.019). Our results showed a significant increase in the presence of C. albicans and C. tropicalis within the mild/moderate dysplasia group compared to other cohorts. Coexistence of these two microorganisms was observed, suggesting a potential transition from a commensal state to an opportunistic pathogen, which could be particularly linked to the onset of oral neoplasia.

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Section: Discussionmentioning

confidence: 99%

Real-Time PCR Detection of Candida Species in Biopsy Samples from Non-Smokers with Oral Dysplasia and Oral Squamous Cell Cancer: A Retrospective Archive Study

İlhan,

Vural,

Gürhan

et al. 2023

Cancers

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“…Candida is known for its cross-kingdom relationships, its near-ubiquitous nature, and ease of cultivation ( 35 , 36 ). Observations indicate that C. albicans is frequently detected species among individuals with OPMD and OSCC ( 37 , 38 ). In a recent study assessing 100 patients with OSCC using biochemical methods, Candida species were identified in 74% of the samples, with C. albicans being the predominant species in 84% ( 38 ).…”

Section: Relationship Of Oral and Systemic Fungi With Oral Cancermentioning

confidence: 99%

“…Earlier studies have illuminated the interplay between distinct microbial communities, implying that these joint communities contribute to dysbiosis or the preservation of a healthy microbiome ( 72 ). While there is a range of data on the role of Candida in oral carcinogenesis ( 37 , 41 , 114 ), other species such as Aspergillus , Penicillium , and Malassezzia require additional investigation ( Figure 4 ). Overall, the study of the oral mycobiome is still in its infancy, and further research aiming at exploring the potential role of fungi in tuning and modulating the host immunity is essential to open up new possibilities for the prevention and adjunctive treatment of oral cancer.…”

Section: Future Directionsmentioning

confidence: 99%

Fungal footprints in oral cancer: unveiling the oral mycobiome

Monteiro,

Kaushik,

de Arruda

et al. 2024

Front. Oral. Health

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Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer, with a high mortality rate. There is growing evidence supporting a link between oral cancer and the microbiome. The microbiome can impact various aspects of cancer, such as pathogenesis, diagnosis, treatment, and prognosis. While there is existing information on bacteria and its connection to oral cancer, the fungi residing in the oral cavity represent a significant component of the microbiome that remains in its early stages of exploration and understanding. Fungi comprise a minuscule part of the human microbiome called the mycobiome. Mycobiome is ubiquitous in the human body but a weakened immune system offers a leeway space for fungi to showcase its virulence. The role of mycobiome as a colonizer, facilitator, or driver of carcinogenesis is still ambiguous. Reactivating the mycobiome that undergoes collateral damage associated with cancer treatment can be watershed event in cancer research. The coordinated, virulent, non-virulent behavior of the fungi once they reach a critical density must be hacked, considering its diagnostic, prognostic and therapeutic implications in cancer. This review highlights the diversity of the mycobiome and its potential role in oral cancer.

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“…Candida albicans is detected among subjects with oral potentially malignant disorders and oral cancer [64].…”

Section: Oral Potentially Malignant Disorders Oral Cancer and Oral My...mentioning

confidence: 99%

Oral Mycobiota: A Narrative Review

Defta,

Albu,

Albu

et al. 2024

Dentistry Journal

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Numerous studies have proven the important role of the oral microbiota in health and disease. The dysfunctionality of the oral microbiota, known as dysbiosis, is incriminated in dental caries, periodontal disease, oral infectious diseases, oral cancer, and systemic disease. The lesser-known component of the oral microbiota, the mycobiota, is now assiduously investigated. Recent technological developments have helped foster the identification of new fungal species based on genomic research. Next-generation sequencing has expanded our knowledge about the diversity, architecture, and relationships of oral microorganisms within the oral cavity. The mycobiome structure and relationships with the bacteriome have been studied to identify a mycobiotic signature. This review aimed to emphasize the latest knowledge of the oral mycobiome.

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Isolation and identification of oral Candida species in potentially malignant disorder and oral squamous cell carcinoma

Cited by 8 publications

References 6 publications

Real-Time PCR Detection of Candida Species in Biopsy Samples from Non-Smokers with Oral Dysplasia and Oral Squamous Cell Cancer: A Retrospective Archive Study

Real-Time PCR Detection of Candida Species in Biopsy Samples from Non-Smokers with Oral Dysplasia and Oral Squamous Cell Cancer: A Retrospective Archive Study

Fungal footprints in oral cancer: unveiling the oral mycobiome

Oral Mycobiota: A Narrative Review

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