ISOLATION AND IDENTIFICATION OF LECTIN GENE IN LICORICE, Glycorrhiza glabra L., PLANT IN EGYPT

Makhlouf, Azza; Al-Sohaimy, S. A.; Moustafa, Y.; Saadani, M. A. El; Makhlouf, H. F.

doi:10.21608/ejgc.2013.10464

Cited by 1 publication

(1 citation statement)

References 18 publications

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“… Fabaceae Root [57] Mannose/glucose Measles virus [58] Cassia fistula L. Fabaceae Seed [59] Galactose IBR [60] Clitoria ternatea L. Fabaceae Seed [61] Galactose and N-acetylgalactosamine MCV, HSV [62] Coccinia indica Wight & Arn. Cucurbitaceae Fruit [63] Chito HBV [64] Corchorus olitorius L. Tiliaceae Leaf [65] Glucose/mannose, galactose Measles virus [66] Cucurbita maxima Duchesne Cucurbitaceae Seed kernels [67] Galactose Not reported Datura stramonium L. Solanaceae Seed [68] N-Acetylglucosamine Potato virus X [69] Erythrina variegata L. Fabaceae seed [70] , [71] Galactose, N-acetylgalactosamine Not reported Glycyrrhiza glabra L. Fabaceae Root [72] Non-specified HAV, HBV, HCV, HIV, SARS-CoV [73] , [74] Kaempferia rotunda L. Zingiberaceae Rhizome [75] Mannose H5N1 [76] ...…”

Section: Introductionmentioning

confidence: 99%

Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies

Ahmed

Jahan

Nissapatorn

et al. 2022

Biomedicine & Pharmacotherapy

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Lectins or clusters of carbohydrate-binding proteins of non-immune origin are distributed chiefly in the Plantae. Lectins have potent anti-infectivity properties for several RNA viruses including SARS-CoV-2. The primary purpose of this review is to review the ability of lectins mediated potential biotherapeutic and bioprophylactic strategy against coronavirus causing COVID-19. Lectins have binding affinity to the glycans of SARS-COV-2 Spike glycoprotein that has N-glycosylation sites. Apart from this, the complement lectin pathway is a “first line host defense” against the viral infection that is activated by mannose-binding lectins. Mannose-binding lectins deficiency in serum influences innate immunity of the host and facilitates infectious diseases including COVID-19. Our accumulated evidence obtained from scientific databases particularly PubMed and Google Scholar databases indicate that mannose-specific/mannose-binding lectins (MBL) have potent efficacies like anti-infectivity, complement cascade induction, immunoadjuvants, DC-SIGN antagonists, or glycomimetic approach, which can prove useful in the strategy of COVID-19 combat along with the glycobiological aspects of SARS-CoV-2 infections and antiviral immunity. For example, plant-derived mannose-specific lectins BanLac, FRIL, Lentil, and GRFT from red algae can inhibit and neutralize SARS-CoV-2 infectivity, as confirmed with in-vitro , in-vivo , and in-silico assessments. Furthermore, Bangladesh has a noteworthy resource of antiviral medicinal plants as well as plant lectins. Intensifying research on the antiviral plant lectins, adopting a glyco-biotechnological approach, and with deeper insights into the “glycovirological” aspects may result in the designing of alternative and potent blueprints against the 21st century's biological pandemic of SARS-CoV-2 causing COVID-19

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