Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

Abstract

Andrographis paniculata (Burm. f.) Nees (Acanthaceae) is a medicinal plant used in many countries. Its major constituents are diterpenoids, flavonoids and polyphenols. Among the single compounds extracted from A. paniculata, andrographolide is the major one in terms of bioactive properties and abundance. Among the andrographolide analogues, 14-deoxy-11,12-didehydroandrographolide is immunostimulatory, anti-infective and anti-atherosclerotic; neoandrographolide is anti-inflammatory, anti-infective and anti-hepatotoxic; 14-deoxyandrographolide is immunomodulatory and anti-atherosclerotic. Among the less abundant compounds from A. paniculata, andrograpanin is both anti-inflammatory and anti-infective; 14-deoxy-14,15-dehydroandrographolide is antiinflammatory; isoandrographolide, 3,19-isopropylideneandrographolide and 14-acetylandrographolide are tumor suppressive; arabinogalactan proteins are anti-hepatotoxic. The four flavonoids from A. paniculata, namely 7-Omethylwogonin, apigenin, onysilin and 3,4-dicaffeoylquinic acid are anti-atherosclerotic.

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

“…By far a vast majority of such suggestive reports concentrate on plant polyphenolics with antioxidative properties, and a more recent report concludes that inhibition of acetylcholinesterase could also be involved in memory function improving effects of structurally diverse phytochemicals and plant polyphenolics (Huang et al 2013). Antioxidative activities of A. paniculata and andrographolide and their other constituents have been described (Lin et al 2009;Chao & Lin 2010), and acetylcholinesterase inhibitory activities of AP and andrographolide in rat brain homogenates have recently been observed in our laboratories (results not shown). However, concentrations of andrographolide necessary for observing its effects in bioassays conducted in vitro were several folds higher than that of its maximal blood levels quantified after its oral intake in rats (Panossian et al 2000).…”

Authentication of a selected medicinal plants using DNA barcoding technique

“…Plants have been used as source of medicine for thousands of years by many cultures and there are many publications [1,6,9,10] that highlighted the usage of plants to treat various kinds of diseases. In recent years, traditional herbal medicines have gained popularity as consumers are reportedly more comfortable taking product that are deemed natural, easily available, cheap and are less side effects.…”

Medicinal plants of the Western ghats as possible inhibitors of oxidation in various biological lipid substrates

“…The utilization of the selected medicinal plants for their biological activities such as anti-inflammatory, antimicrobial, antitumor, hypoglycemic, antidiabetic, antiviral, hepato and renoprotective effects have been reported (Chao and Lin, 2010;Akbar, 2011;Solanki and Zaveri, 2012;Shirisha et al, 2013;Jayakumar et al, 2013;Pawar and Pawar, 2014;Kala, 2016;). AnP has been used as a blood purifier in treating blood related diseases such as skin eruptions, boils, scabies, and chronic undetermined fevers (Akbar, 2011).…”