Isolation and identification of antioxidants from Sophora japonica

Abstract

A new flavonol triglycoside, kaempferol 3-O-alpha-L-rhamnopyranosyl-(1 --> 6)-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside (1), as well as two known kaempferol 3-O-[alpha-L-rhamnopyranosyl-(1 --> 6)]-[beta-D-glucopyranosyl-(1 --> 2)]-beta-D-glucopyranoside (2) and kaempferol 3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside-7-O-alpha-L-rhamnopyranoside (3), were isolated from the n-BuOH extract of the pericarps of Sophora japonica by bioassay-guided fractionation. The structure of compound 1 was established by UV, IR, MS, and one- and two-dimensional NMR spectroscopy, including DEPT, NOESY, DQF-COSY, TOCSY, HMQC, and HMBC experiments. Compounds 1-3 showed antioxidative activity in DPPH and cytochrome-c assay using HL-60 cell system.

Antihyperglycemic Activity of Herb Extracts on Streptozotocin-Induced Diabetic Rats

“…Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa have traditionally been used as medicines for the treatment of inflammation-related diseases, and recent studies have reported that their extracts possess antioxidant, anti-inflammatory, and anti-tumor effects. [4][5][6][7][8] These herbs contain large numbers of active compounds, such as phenolic acids, flavonoids, and triterpenoid saponins, which have known ROS scavenging effects. 5,6,9) Streptozotocin (STZ) produces oxygen radicals in the body by causing pancreatic injury, and this then causes blood sugar increases.…”

“…[4][5][6][7][8] These herbs contain large numbers of active compounds, such as phenolic acids, flavonoids, and triterpenoid saponins, which have known ROS scavenging effects. 5,6,9) Streptozotocin (STZ) produces oxygen radicals in the body by causing pancreatic injury, and this then causes blood sugar increases. Therefore, in the present study, we investigated the effects of 80% ethanolic extract of selected herbs on blood glucose levels and on lipid peroxidation in normal and streptozotocin-induced diabetic rats.…”

Active constituents from Sophora japonica exhibiting cellular tyrosinase inhibition in human epidermal melanocytes

“…Tel. : +886 2 2736 1661x6151; fax: +886 2 2735 7983. inflammation (Kim et al, 2003a,b), inhibits anti-Lea agglutinin (Yamamoto, 1982), functions as an antioxidant (Tang et al, 2002b), and has anti-tumor activity (Abe et al, 1996;Kang et al, 2006).…”

Downregulation of Cyclin D1 by Sophorae Flos through Proteasomal Degradation in Human Colorectal Cancer Cells

“…In addition, Sophorae Flos have been reported to exhibit various pharmacological properties such as anti-diabetes (Jung et al, 2006), anti-inflammation (Kim et al, 2003a;Kim et al, 2003b), anti-oxidant (Tang et al, 2002) and anti-cancer (Abe et al, 1996;Kang et al, 2006). In anti-cancer activity, our group has reported that the flower buds of Sophorae Flos exert anti-cancer activity through upregulating activating transcription factor 3 in human colorectal cancer cells (Lee et al, 2015).…”