Isolation and Hypoglycaemic Activity of Panaxans A, B, C, D and E, Glycans of<i>Panax ginseng</i>Roots<sup>1</sup>

Konno, Chohachi; Sugiyama, Kazuhiko; Kano, Mitsuyo; Takahashi, Michiko; Hara, Hiroshi

doi:10.1055/s-2007-969757

Cited by 96 publications

(33 citation statements)

References 1 publication

(1 reference statement)

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“…Of these only the former have shown glycemic effects. Panaxans A-L (Konno et al, 1984Oshima et al, 1985Oshima et al, , 1987 and quinquefolans A-C have shown hypoglycemic effects with varying potencies when administered as intraperintoneal injections in both normal and alloxan induced hyperglycemic mice. However, their influence is dubious.…”

Section: Variable Effects Of American Ginsengmentioning

confidence: 99%

Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia

et al. 2003

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Background:We have repeatedly reported that American ginseng (AG) with a specific ginsenoside profile significantly decreases postprandial glycemia. Whether this effect is reproducible using AG with a different profile is unknown. We therefore investigated the effect of a different batch of AG on glycemia following a 75 g oral glucose tolerance test (OGTT). Methods: Using a randomized, single blind design, 12 normal subjects (six males and six females, aged 31 AE 3 y, body mass index (BMI) 28 AE 2 kg=m 2 ) received 6 g AG or placebo 40 min before a 75 g OGTT. The protocol followed the guidelines for the OGTT, with venous blood samples drawn at 7 40, 0, 15, 30, 45, 60, 90 and 120 min. Ginsenosides in the AG were assessed by established methods for HPLC-UV. Results: Repeated measures analysis of variance demonstrated that there was no significant effect of the AG on incremental plasma glucose (PG) or insulin (PI) or their areas under the curve Indices of insulin sensitivity (insulin sensitivity index (ISI)) and release (DPI 30-0 =DPG 30-0 ) calculated from the OGTT were also unaffected. The AG contained 1.66% total ginsenosides, 0.90% (20S)-protopanaxadiol (PPD) ginsenosides, and 0.75% (20S)-protopanaxatriol (PPT) ginsenosides, with the following key ratios: PPD:PPT of 1.2, Rb 1 :Rg 1 of 8.1, and Rb 2 :Rc of 0.18. Conclusions: The present batch of AG was unable to reproduce the postprandial hypoglycemic effects we observed previously. Possible explanations for this discrepancy include marked decrements in total ginsenosides and the key ratios PPD:PPT, Rb 1 :Rg 1 , and Rb 2 :Rc. These data suggest that the ginsenoside profile of AG might play a role in its hypoglycemic effects. The involvement of other components cannot, however, be precluded.

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Section: Variable Effects Of American Ginsengmentioning

confidence: 99%

Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia

et al. 2003

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“…22, No. 5,1990 spectra of deprotected glycosylated polysaccharide (6) in D 2 0 showed the complete removal of protective groups (Figure 3). Benzyl groups in the main chain and acetyl groups in the branching unit were simultaneously removed under this condition.…”

Section: Removal Of Protective Groups Into Branched Polysaccharides Hmentioning

confidence: 98%

“…22, No. 5,1990 O-benzyl-3-0-tert-butyldimethylsilyl-( 1-+6)-rx-D-glucopyrananan (2) having a numberaverage molecular weight of 6.6 x 10 4 in high yield. The 1 H NMR spectrum of the polymer was assigned by 2-dimensional lH_1H COSY spectrum ( Figure I).…”

Section: Synthesis Of 24-di-o-benzyl-(1-+6)-rx-d-glucopyranan (3)mentioning

confidence: 99%

Synthesis and Sulfation of Branched Dextrans

Hatanaka

Hirobe

Yoshida

et al. 1990

Polym J

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ABSTRACT:2,4-Di-O-benzyl-(1 ..... 6)-Il-D-glucopyranan, which was synthesized by ringopening polymerization of 1,6-anhydro-2,4-di-O-benzyl-3-0-tert-butyldimethylsilyI-P-D-glucopyranose and subsequent desilylation, was p-glucosylated or Il-mannosylated by the orthoester method. Deprotection of glycosylated polysaccharides with sodium in liquid ammonia was performed to give branched dextrans with free hydroxyl groups. Sulfation of the branched dextrans was carried out with piperidine N-sulfonic acid in dimethylsulfoxide to give new heparinoids. The Polymers were characterized by NMR spectroscopy, gel permeation chromatography, and optical rotation.KEY WORDS Ring-Opening Polymerization / Anhydrosugar / Branched Polysaccharide / Dextran / Sulfated Polysaccharide / Orthoester Method /

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“…Oshima et al 33 , Konno et al 34,35 e Tomoda et al 36 isolaram componentes do P. ginseng com atividade hipoglicemiante, que, à época, denominaram panaxanas. Dey et al 37 compararam os efeitos da raiz e do fruto de P. ginseng, constatando que o segundo exerce ação normoglicêmica posprandial mais acentuada em camundongos com profunda obesidade (modelo semelhante a humanos com diabetes tipo II) do que as raízes.…”

Section: Introductionunclassified

Análise comparativa de embalagens secundárias e bulas de medicamentos contendo Panax ginseng C. A. Meyer

2007

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The information provided on package inserts and inner wrapping of eight products containingSegundo dados da indústria farmacêutica, no Brasil, os fitoterápicos movimentam 400 milhões de Dólares por ano, representando 7% do segmento farmacêutico, com perspectiva de aumento nos próximos anos 3 . O seu consumo é prática comum, também, em outros países, como os Estados Unidos 4 , onde mais de um terço da população faz uso de alguma forma de medicina não convencional além de suplementos dietéticos ou, então, de dietas com megavitaminas para a cura das doenças 5 .No Brasil, muitos medicamentos fitoterápicos são classificados como medicamentos de venda livre, ou seja, sua utilização ocorre, normalmen-ARTIGO ARTICLE

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Isolation and Hypoglycaemic Activity of Panaxans A, B, C, D and E, Glycans ofPanax ginsengRoots¹

Cited by 96 publications

References 1 publication

Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia

Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia

Synthesis and Sulfation of Branched Dextrans

Análise comparativa de embalagens secundárias e bulas de medicamentos contendo Panax ginseng C. A. Meyer

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Isolation and Hypoglycaemic Activity of Panaxans A, B, C, D and E, Glycans ofPanax ginsengRoots1

Cited by 96 publications

References 1 publication

Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia

Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia

Synthesis and Sulfation of Branched Dextrans

Análise comparativa de embalagens secundárias e bulas de medicamentos contendo Panax ginseng C. A. Meyer

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Product

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Isolation and Hypoglycaemic Activity of Panaxans A, B, C, D and E, Glycans ofPanax ginsengRoots¹