2003
DOI: 10.1038/sj.ejcn.1601550
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Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia

Abstract: Background:We have repeatedly reported that American ginseng (AG) with a specific ginsenoside profile significantly decreases postprandial glycemia. Whether this effect is reproducible using AG with a different profile is unknown. We therefore investigated the effect of a different batch of AG on glycemia following a 75 g oral glucose tolerance test (OGTT). Methods: Using a randomized, single blind design, 12 normal subjects (six males and six females, aged 31 AE 3 y, body mass index (BMI) 28 AE 2 kg=m 2 ) rec… Show more

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Cited by 70 publications
(46 citation statements)
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References 31 publications
(22 reference statements)
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“…Various formulations prepared from the Panax ginseng root have been marketed as dietary supplements, especially in China where it is frequently used as a food additive and as raw materials of healthy food rather than therapeutic agents (Gillis, 1997;Shen et al, 2003). Bioactive compounds from medicinal plants including ginseng are known to protect against oxidative stress from reactive oxygen species and prevent lipid per-oxidation (Sievenpiper et al, 2003;Fuzzati, 2004).…”
Section: Jojoba Extractmentioning
confidence: 99%
“…Various formulations prepared from the Panax ginseng root have been marketed as dietary supplements, especially in China where it is frequently used as a food additive and as raw materials of healthy food rather than therapeutic agents (Gillis, 1997;Shen et al, 2003). Bioactive compounds from medicinal plants including ginseng are known to protect against oxidative stress from reactive oxygen species and prevent lipid per-oxidation (Sievenpiper et al, 2003;Fuzzati, 2004).…”
Section: Jojoba Extractmentioning
confidence: 99%
“…더욱이 최근에는 ginsenoside의 절대함량 뿐만 아니라 각 ginsenoside의 성분 조성비 (PD/PT 비율)가 당뇨병의 유효성과 관련된 약리 효과 발현에 중요한 역할을 시사하는 연구결과가 발표되고 있어 주목을 받 고 있다 (Sievenpiper JL et al, 2003 Rg 3 의 약리활성으로 혈관신생억제를 통한 항종양효과 및 항암 제 효과 상승 (Liu et al, 2009), 암세포의 정상세포내로 침 윤과 혈관신생의 억제를 통한 암세포 전이억제 (Mochizuki M et al, 1995, Xu et al, 2008, 항암제 내성 억제 (Park et al, 1995), 혈관 확장 작용 (Kim, 2008), 혈액순환촉진 (Matsuda et al, 2000), 혈소판 응집억제 (Kim, 2008;Samukawa et al, 1992), 인슐린 분비 촉진작용 , 항비만효과 (Hwang et al, 2009) (Jay et al, 1984;Kulkarmi and Anderson, 1984). LITERATURE CITED…”
unclassified
“…Because the content of NAG and profile of ginsenosides differs from P ginseng, its potential effect on BP cannot be inferred from the latter and requires independent scrutiny. Also, batches of NAG may vary in their content of ginsenosides 11,12 and may consequently yield inconsistent hemodynamic effects. Thus, to comprehensively determine the effect of NAG on BP, multiple batches need to be tested.…”
mentioning
confidence: 99%