2014
DOI: 10.1080/14786419.2014.979416
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Isolation and evaluation of cytogenetic effect of Brahmi saponins on cultured human lymphocytes exposedin vitro

Abstract: Major saponins of Brahmi (Bacopa monniera, Fam: Scrophulariaceae) - bacosides A and B - were isolated from the total methanol extract and characterised based on melting point, TLC, IR, (1)H NMR and (13)C NMR. They were evaluated for their in vitro cytogenetic effects on human peripheral blood lymphocytes by chromosomal aberration (CA) assay and sister chromatid exchange (SCE) assay. The frequency of chromatid type aberrations and reciprocal interchanges between sister chromatids in the treated cells was scored… Show more

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Cited by 4 publications
(4 citation statements)
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“…Interaction of protein and ligand were shown in Figures 6 – 8 . Some previous study suggested that anti-tumor activity of Bacopa due to bacosides,[ 9 22 ] cucurbitacins,[ 23 24 ] and also betulinic acid. [ 25 ] This docking study presented probable mechanism of action of anti-tumor activity of DBM.…”
Section: Resultsmentioning
confidence: 99%
“…Interaction of protein and ligand were shown in Figures 6 – 8 . Some previous study suggested that anti-tumor activity of Bacopa due to bacosides,[ 9 22 ] cucurbitacins,[ 23 24 ] and also betulinic acid. [ 25 ] This docking study presented probable mechanism of action of anti-tumor activity of DBM.…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, the active constituent of BM responsible for its pharmacological effects is bacoside A, a mixture of dammarane‐type triterpenoid saponins containing sugar chains linked to a steroid aglycone skeleton. Distinctive saponins called ‘bacosides’, especially bacoside A, have been considered to be the foremost bioactive constituents responsible for the cognitive effects of BM (Kalachaveedu et al ., ). Bacoside A is a mixture of four triglycosidic saponins, namely, bacoside A3, bacopaside II, bacopasaponin C and the jujubogenin isomer of bacosaponin C (bacopaside X) (Tothiam et al ., ; Deepak et al ., ).…”
Section: Discussionmentioning
confidence: 97%
“…Results on chronic treatment of D. melanogaster larvae suggested no genotoxic effect of S. brasiliensis extracts at the tested concentrations. For both crosses, there was no significant difference in the frequency of mutant spots in flies treated with HEE, EAF, and negative control (Table 1 and 2). HEE and EAF had negative results for small single spots and large single spots.…”
Section: St Hbmentioning
confidence: 92%
“…Here, we used three mutant lineages of D. melanogaster (1) multiple wing hairs (mwh): mwh/mwh; (2) flare-3 (flr 3 /In (3LR)TM3, rip p sep l(3)89Aabx 34e e Bd S ; and (3) ORR; flare-3 (ORR/ORR; flr 3 /In (3LR)TM3, rip p sep l(3)89Aabx 34e e Bd S ). Considering a proportion 2:1 for females and males, we made two different crosses: the standard cross (ST), in which flr3 individuals were females and mwh individuals were males (Graf et al, 1989); and the high bioactivation cross (HB), in which ORR; flr3 individuals were females and mwh individuals were males (Graf and Van Schaik, 1992).…”
Section: Somatic Mutation and Recombination Test (Smart)mentioning
confidence: 99%