Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis

Chang, Chi Fen; Hsu, Yeh‐Liang; Lee, Chao Ying; Wu, Chia Hua; Wu, Yang Chang; Chuang, Ta Hsien

doi:10.3390/ijms16023980

Cited by 51 publications

(18 citation statements)

References 14 publications

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“…In addition, it strongly inhibited HGF production stimulated by various HGF inducers in human dermal fibroblasts, probably through events downstream of MAPK activation . More recently, its significant cytotoxic effects against MCF‐7, NCI‐H460, and SF‐268 (glioblastoma) cell lines (IC 50 = 9.4, 8.5, and 22.6 μM) have been reported . Tryptanthrin significantly inhibits K562 cell proliferation in a time‐ and dose‐dependent manner, and has proliferation‐attenuating and apoptosis‐inducing effects on K562 cells.…”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 96%

Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

153

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To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

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Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 96%

Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

153

View full text Add to dashboard Cite

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“…Tryptanthrin was found to inhibit the growth of human gastric cancer (HGC), lung cancer (HLC), and promyelocytic leukemia HL-60 cells with IC 50 values of 1.5-4.2 µg/mL [67]. It showed significant cytotoxicity against non-small cell lung cancer NCI-H460, human glioblastoma SF-268, and human breast cancer MCF-7 cell lines with IC 50 values of 8.5-22.6 µM [78]. Tryptanthrin also exhibited a multi-drug resistance reversing effect in doxorubicin-resistant breast cancer MCF-7 cells (MCF-7/adr), which is higher than that of the multi-drug resistance (MDR)-reversing agent Verapamil through down-regulation of MDR1 gene expression, and partly by modulating the GSTpi-related pathway, which is a non-transporter pathway [71,72].…”

Section: Anti-tumor Activitymentioning

confidence: 99%

Isatis tinctoria L. (Woad): A Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies

Speranza

Miceli

Taviano

et al. 2020

Plants

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Isatis tinctoria L. (Brassicaceae), which is commonly known as woad, is a species with an ancient and well-documented history as an indigo dye and medicinal plant. Currently, I. tinctoria is utilized more often as medicinal remedy and also as a cosmetic ingredient. In 2011, I. tinctoria root was accepted in the official European phytotherapy by introducing its monograph in the European Pharmacopoeia. The biological properties of raw material have been known from Traditional Chinese Medicine (TCM). Over recent decades, I. tinctoria has been investigated both from a phytochemical and a biological point of view. The modern in vitro and in vivo scientific studies proved anti-inflammatory, anti-tumour, antimicrobial, antiviral, analgesic, and antioxidant activities. The phytochemical composition of I. tinctoria has been thoroughly investigated and the plant was proven to contain many valuable biologically active compounds, including several alkaloids, among which tryptanthrin, indirubin, indolinone, phenolic compounds, and polysaccharides as well as glucosinolates, carotenoids, volatile constituents, and fatty acids. This article provides a general botanical and ethnobotanical overview that summarizes the up-to-date knowledge on the phytochemistry and biological properties of this valuable plant in order to support its therapeutic potential. Moreover, the biotechnological studies on I. tinctoria, which mainly focused on hairy root cultures for the enhanced production of flavonoids and alkaloids as well as on the establishment of shoot cultures and micropropagation protocols, were reviewed. They provide input for future research prospects.

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“…The structures in the region within the blue frame are the range of lacking residues and would be filled by homology modeling. Sinularia flexibilis [31] TDEC2020CN000246 -9.0 -9.8 Phaius mishmensis [32,51] TDEC2019CA001707 -8.9 -8.3…”

Section: Supporting Information S1 Fig the Structures Of Sars-cov-2 mentioning

confidence: 99%

The discovery of potential natural products for targeting SARS-CoV-2 spike protein by virtual screening

Chen

Tang

et al. 2020

Preprint

Self Cite

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters into the cells through its spike proteins binding to human angiotensin-converting enzyme 2 (ACE2) protein and causes virus infection in host cells. Until now, there are no available antiviral drugs have been reported that can effectively block virus infection.The study aimed to discover the potential compounds to prevent viral spike proteins to bind to the human ACE2 proteins from Taiwan Database of Extracts and Compounds (TDEC) by structure-based virtual screening. In this study, to rapidly discover potential inhibitors against SARS-CoV-2 spike proteins, the molecular docking calculation was performed by AutoDock Vina program. Herein, we found that 39 potential compounds may have good binding affinities and can respectively bind to the viral receptor-binding domain (RBD) of spike protein in the prefusion conformation and spike-ACE2 complex protein in silico. Among those compounds, especially natural products thioflexibilolide A and candidine that were respectively isolated from the soft corals Sinularia flexibilis and Phaius mishmensis may have better binding affinity than others. This study provided the predictions that these compounds may have the potential to prevent SARS-CoV-2 spike protein from entry into cells.

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Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis

Cited by 51 publications

References 14 publications

Biologically active quinoline and quinazoline alkaloids part II

Biologically active quinoline and quinazoline alkaloids part II

Isatis tinctoria L. (Woad): A Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies

The discovery of potential natural products for targeting SARS-CoV-2 spike protein by virtual screening

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