Isolation and Chemical Analysis of a Fatty Acid Fraction of Kalanchoe pinnata with a Potent Lymphocyte Suppressive Activity

Almeida, Ana Paula de; Silva, S. A. G. da; Souza, M. L. M. de; Lima, L.M.T.R.; Rossi-Bergmann, Bartira; Moraes, V. L. G. da; Costa, Sônia Soares

doi:10.1055/s-2000-11131

Cited by 42 publications

(33 citation statements)

References 8 publications

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“…Other carboxylic acids include, according to a previous review, oxalic acid, citric acid, isocitric acid, cinnamic acid, succinic acid, oxaloacetate, and phosphoenolpyruvate [2]. In addition, the fatty acids palmitic, stearic, arachidic, and behenic acids [49], as well as various vitamins (ascorbic acid, riboflavin, thiamine, niacin, pyridoxine), were reported [2]. The rare vitamin E congeners β-, γ-, and δ-tocomonoenols were identified in the leaves of B. daigremontianum, together with the widespread α-, γ-and δ-tocopherols [50].…”

Section: Miscellaneous Metabolitesmentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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Section: Miscellaneous Metabolitesmentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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“…With respect to pharmacological properties of B. pinnatum, antileishmanial [12], antiulcer [13], antibacterial [14,15], antitumor promoting [16], immunosuppressive [17], and antihypertensive effects [18] have been reported. Compounds identified in the plant include flavonoids, triterpenes, phytosterols, bufadienolides, fatty acids, and minerals [19].…”

Section: Introductionmentioning

confidence: 99%

Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

et al. 2013

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Bryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatum leaves and to identify chromatographic markers for quality control and safety assessment of medicinal preparations. Preliminary HPLC-PDA-ESIMS analyses revealed that flavonoid glycosides were the main UV-absorbing constituents in the MeOH extract of B. pinnatum. Two phenolic glucosides, syringic acid -D-glucopyranosyl ester (1) and 4'-O--D-glucopyranosyl-cis-p-coumaric acid (2), as well as nine flavonoids (3-11) including kaempferol, quercetin, myricetin, acacetin, and diosmetin glycosides were unambiguously identified by 1H and 2D NMR analysis after isolation from a MeOH extract. The flavonol glycosides quercetin 3-O--L-arabinopyranosyl-(1 → 2)--L-rhamnopyranoside 7-O--D-glucopyranoside (3) and myricetin 3-O--L-arabinopyranosyl-(1 → 2)--L-rhamnopyranoside (4) were new natural products. With the aid of HPLC-PDA-APCIMS and authentic references isolated from the related species B. daigremontianum, the presence of four bufadienolides, bersaldegenin-1-acetate (12), bryophyllin A (13), bersaldegenin-3-acetate (14), and bersaldegenin-1,3,5-orthoacetate (15) AbstractBryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders, and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatum leaves, and to identify chromatographic markers for quality control and safety

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“…Kalanchoe brasiliensis -another medicinal species popularly known by the same name (saião) and widely used against rheumatism and infl ammatory processes -showed protection against the local effects (edema, hemorrhage and necrosis) of Bothrops alternatus venom in mice (Fonseca et al, 2004) and anti-infl ammatory activity (Mourão et al, 1999;Ibrahim et al, 2002;Falcão et al, 2005;Costa et al, 2006)." Our results showed that an enriched saturated fatty acid fraction from K. pinnata (KP) could play an important role on its immunosuppressive in vivo effect (Almeida et al, 2000).…”

Section: Introductionmentioning

confidence: 80%

1-octen-3-O-alpha-L-arabinopyranosyl-(1 -> 6)-beta-glucopyranoside, a minor substance from the leaves of Kalanchoe pinnata (Crassulaceae)

Almeida¹,

Muzitano²,

Costa³

2006

Rev. bras. farmacogn.

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RESUMO:"1-Octeno-3-O--L-arabinopiranosil-(1 6)--glicopiranosídeo, u m a substância minoritária das folhas de Kalanchoe pinnata (Crassulaceae)". A partir das folhas de Kalanchoe pinnata (Crassulaceae), uma planta medicinal amplamente utilizada contra processos infl amatórios e que apresenta importante atividade imunossupressora e antileishmania, foi isolado um álcool vinílico diglicosilado minoritário, caracterizado como 1-octeno-3-O--L-arabinopiranosil-(1 6)--glicopiranosídeo baseado em RMN mono e bi-dimensional e em CG-EM, após sucessivos processos cromatográfi cos em coluna. Esta molécula é um derivado hidrossolúvel da aglicona 1-octen-3-ol, molécula que atua como atrativo para polinizadores e sinalizador de defesa contra herbivoria. Unitermos:Kalanchoe pinnata, Crassulaceae, extrato etanólico, 1-octeno-3-O--Larabinopiranosil-(1 6)--glicopiranosídeo, defesa da planta, atrativo para polinizadores.ABSTRACT: From the leaves of Kalanchoe pinnata (Crassulaceae), a medicinal plant widely used against infl ammatory processes which exhibit a important immunosuppressive and antileishmanial activities, was isolated a minor vinylic aliphatic alcohol diglycoside which structure was proposed as the known 1-octen-3-O--L-arabinopyranosyl-(1 6)--glucopyranoside based on 1 H and 13 C mono and bi-dimensional NMR experiments and GC-MS analysis, after successive chromatographic column procedures. This molecule is a water-soluble derivative of the volatile aglicone 1-octen-3-ol that appears to be attractant of pollinators and signalling of defence against herbivores.

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Isolation and Chemical Analysis of a Fatty Acid Fraction of Kalanchoe pinnata with a Potent Lymphocyte Suppressive Activity

Cited by 42 publications

References 8 publications

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

1-octen-3-O-alpha-L-arabinopyranosyl-(1 -> 6)-beta-glucopyranoside, a minor substance from the leaves of Kalanchoe pinnata (Crassulaceae)

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