Isolation and Characterization of Compounds from the Methanolic Bark Extract of <i>Adenanthera pavonina</i> L.

Ara, Arzumand; Saleh‐E‐In, Md. Moshfekus; Ahmad, M. U.; Hashem, Md. Abul; Hasan, Choudhury Mahmood

doi:10.1080/22297928.2020.1745684

Cited by 2 publications

(4 citation statements)

References 18 publications

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“…7-methoxy catechin ( FL-3 ): Yellow powder, brown gummy solid; 1 H-NMR (600 MHz, DMSO-d, δ = ppm): 6.70 (d, 1H, J = 11.2 Hz, H-5′), 6.59 (dd, 1H, J = 10.8 & 3.2 Hz, H-6′), 6.59 (d, 1H, J = 3.2 Hz, H-2′), 5.86 (s, 1H, H-8), 5.69 (1H, s, H-6), 4.47 (d, 1H, J = 10.4 Hz, H-2), 3.71 (d, J = 6.8, 10.4 & 11.6 Hz, H-3), 3.16 (s, OCH 3 , H-11), 2.54 (dd, 1H, J = 20.8 and 6.8 Hz, H-4α), 2.50 (1H, m, H-4β); 13 C-NMR (150 MHz, DMSO-d, δ = ppm): 156.3, 156.1, 155.2, 144.8, 130.5, 118.4, 115.1, 114.4, 99.1, 95.2, 93.9, 80.8, 66.2, 48.6, 27.6; ESI-HRMS (positive): m / z 291.0729 [M − CH 2 + H] + [ 63 , 64 , 65 ].…”

Section: Methodsmentioning

confidence: 99%

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

et al. 2021

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In the current study, in vitro antimicrobial and antioxidant activities and in vivo anti-inflammatory and analgesic activities of Scutellaria edelbergii Rech. f. (crude extract and subfractions, i.e., n-hexane, ethyl acetate (EtOAc), chloroform, n-butanol (n-BuOH) and aqueous) were explored. Initially, extraction and fractionation of the selected medicinal plant were carried out, followed by phytochemical qualitative tests, which were mostly positive for all the extracts. EtOAc fraction possessed a significant amount of phenolic (79.2 ± 0.30 mg GAE/g) and flavonoid (84.0 ± 0.39 mg QE/g) content. The EtOAc fraction of S. edelbergii exhibited appreciable antibacterial activity against Gram-negative (Escherichia coli and Klebsiella pneumoniae) strains and significant zones of inhibition were observed against Gram-positive bacterial strains (Bacillus subtilis and Staphylococcus aureus). However, it was found inactive against Candida Albicans and Fusarium oxysporum fungal strains. The chloroform fraction was the most effective with an IC50 value of 172 and 74 µg/mL against DPPH (1,1-Diphenyl-2-picryl-hydrazyl) and ABTS assays, in comparison with standard ascorbic acid 59 and 63 µg/mL, respectively. Moreover, the EtOAc fraction displayed significant in vivo anti-inflammatory activity (54%) using carrageenan-induced assay and significant (55%) in vivo analgesic activity using acetic acid-induced writing assay. In addition, nine known compounds, ursolic acid (UA), ovaul (OV), oleanolic acid (OA), β-sitosterol (BS), micromeric acid (MA), taraxasterol acetate (TA), 5,3′,4′-trihydroxy-7-methoxy flavone (FL-1), 5,7,4′-trihydroxy-6,3′-dimiethoxyflavone (FL-2) and 7-methoxy catechin (FL-3), were isolated from methanolic extract of S. edelbergii. These constituents have never been obtained from this source. The structures of all the isolated constituents were elucidated by spectroscopic means. In conclusion, the EtOAc fraction and all other fractions of S. edelbergii, in general, displayed a significant role as antibacterial, free radical scavenger, anti-inflammatory and analgesic agents which may be due to the presence of these constituents and other flavonoids.

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Section: Methodsmentioning

confidence: 99%

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

et al. 2021

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“…Further, a benzoic acid derivative 2-hydroxy-1,2diphenyl ethanone (benzoin) (66) was discovered in the second experiment from the ethyl acetate fraction of methanolic bark extract [29]…”

Section: Fatty Acids and Estersmentioning

confidence: 99%

“…On the other hand, oleanane type triterpenoids saponins aridanin (12) and 3-[(2acetamido-2-deoxy-β-D-glucopyranosyl)-oxy)-16α-hydroxyolean-12-en-28-oic acid (13) were isolated from the ethanolic extract of the stems and leaves [28]. Later on Ara et al, 2020 isolated a few oleanane type triterpenoids 3-[(2'-acetamido-2'-deoxy-β-Dglucopyranosyl)oxy]-olean-12-en-28-oic acid (14), 3-[(2'-acetamido-2'-deoxy-β-D-glucopyranosyl)oxy]-16α-hydroxyolean-12-en-28-oic acid (15) 3-O--Dglucopyranosyl-21-methylcarboxy-olean-12-en-28oic-acid (16) and 3-O-β-D-glucopyranosyl-21-methyl carboxy-olean-18-en-28-oic acid(17) from the bark of the methanol extract[29]. In addition, a triterpenoid squalene(18) was also found in the leaves[21]…”

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confidence: 99%

“…Stems and leaves[28] 3-[(2-acetamido-2-deoxy-β-D-Glucopyranosyl)-oxy)-16α-hydroxyolean-12-en-28-oic acid, (13) Stems and leaves[28] 3-[(2'-acetamido-2'-deoxy-β-D-glucopyranosyl)oxy]-olean-12-en-28-oic acid(14)Bark[29].3-[(2'-acetamido-2'-deoxy-β-D-glucopyranosyl)oxy]-16-α-hydroxyolean-12en-28-oic acid (15) Bark [29]. 3-O--D-glucopyranosyl-21-methylcarboxy-olean-12-en-28-oic-acid (16) Bark [29].…”

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confidence: 99%

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Botany and phytochemistry of Adenanthera pavonina L (Rakta Kambal)-A mini review

Saleh‐E‐In¹,

Kar²,

Ara³

et al. 2022

JPP

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The plant Adenanthera pavonina L. (Leguminosae) is a traditionally and pharmacologically important medicinal plant of the Asian subcontinent. Various parts of the plant particularly seeds, roots and leaves are traditionally used for the treatment of rheumatism, inflammations, diarrhoea, boils and lowering of blood pressure. A critical phytochemical survey was executed on the phytochemistry of A. pavonina, and found a plethora of phytochemicals that consisted of various phytochemical groups namely phytosterols, saponins and sapogenins, flavonoids, alkaloid, alcohols, hydrocarbons, fatty acids and ester, carbohydrates, sugars and amino acids. Current phytochemical studies reveal the presence of 71 isolated compounds, a few of which have been shown different pharmacological activities. This review compiles a wealth of information on the phytochemistry of A. pavonina from the standpoints of chemistry and medicine that would be explored in order to carry on future research in the discovery and development of new therapeutic lead drug molecules.

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Isolation and Characterization of Compounds from the Methanolic Bark Extract of Adenanthera pavonina L.

Cited by 2 publications

References 18 publications

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

Botany and phytochemistry of Adenanthera pavonina L (Rakta Kambal)-A mini review

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