Isolation and characterization of bioactive xanthones from Hippocratea africana (Willd.)Loes.ex Engl. (Celastraceae)

Umoh, Uwemedimo F.; Thomas, Paul S.; Essien, Emmanuel E.; Okokon, Jude E.; Leo, Marinella De; Ajibesin, K. K.; Flamini, Guido; Eseyin, Olorunfemi A.

doi:10.1016/j.jep.2021.114031

Cited by 11 publications

(13 citation statements)

References 21 publications

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“…As of today, thousands of natural xanthone derivatives have been isolated from Amaranthaceae, Anacardiaceae, Annonaceae, Asteraceae, Clusiaceae, Eriocaulaceae, Fabaceae, Filicineae, Gentianaceae, Guttiferae, Hypericaeae, Moraceae, Leguminosae, Loganiaceae, and Polygalaceae families [42][43][44][45][46][47][48][49][50][51][52]. Within 2012-2019, as many as 1225 xanthone derivatives have been isolated from natural sources.…”

Section: Isolation Of Xanthone Derivativesmentioning

confidence: 99%

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

et al. 2021

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The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible. Among the available anticancer drugs, almost all of them contain heterocyclic moiety in their chemical structure. Xanthone is a heterocyclic compound with a dibenzo-γ-pyrone framework and well-known to have “privileged structures” for anticancer activities against several cancer cell lines. The wide anticancer activity of xanthones is produced by caspase activation, RNA binding, DNA cross-linking, as well as P-gp, kinase, aromatase, and topoisomerase inhibition. This anticancer activity depends on the type, number, and position of the attached functional groups in the xanthone skeleton. This review discusses the recent advances in the anticancer activity of xanthone derivatives, both from natural products isolation and synthesis methods, as the anticancer agent through in vitro, in vivo, and clinical assays.

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Section: Isolation Of Xanthone Derivativesmentioning

confidence: 99%

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

et al. 2021

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“…A xanthone aglycone, norathyriol demonstrated higher inhibition of DPPH radical as compared to isoathyriol due to the substitution of the free hydroxyl group at C-6 with methoxy group [56]. In addition, mangiferin was reported to have potent superoxide (O2·ˉ) scavenging ability with an IC50 of 14.95 ± 2.95 µg/ml [57].…”

Section: Antioxidant and Cytotoxic Activities Of Xanthones Present In...mentioning

confidence: 99%

A Review on the Cytotoxic and Antimicrobial Properties of Xanthones from Cratoxylum cochinchinense

Lee¹,

Mojulat²,

Thangaperagasam³

et al. 2023

J.Trop.Life.Science

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Cratoxylum cochinchinenseis a perennial plant found in Southeast Asia, having di-verse terminologies in various Southeast Asian countries. It has been traditionally used as medicine, tea and food spice until today. Its phytochemical analysis reveals a rich array of bioactive compounds in different parts of the plant, specifically xan-thones, which are scientifically determined to be the most abundant secondary me-tabolites in C. cochinchinense. Xanthones do possess numerous beneficial properties and are actively researched to unlock its vast potential. It could be synthesized both biologically and synthetically, where the latter method is gaining much interest among researchers to improve its biological properties. Due to limited compiled re-sources on the biological benefits of xanthones from C. cochinchinense, this paper aims to review theircytotoxic properties specifically towards cancer cells, as well as their antimalarial and antibacterial effects in order to further support the medicinal use of this plan

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“…The set up was allowed to stand for 72 hours with occasional shaking and re-macerated for another 72 hours for maximum yield. The extract was filtered, concentrated until constant weights were achieved, then stored in a refrigerator at 2-8 o C [19].…”

Section: Preparation and Extractionmentioning

confidence: 99%

Ameliorating Effects of Solanum anomalum Thonn. Ex. Schumach Fruit Extracts on Paracetamol-induced Kidney Injuries and Haemato-biochemical Indices in Rats

Offor

Akpan

Tologbonse

et al. 2022

JOCAMR

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Paracetamol (acetaminophen) is a widely used non-opioid analgesic and antipyretic drug that is safe at therapeutic doses but toxic to the liver and kidneys in overdose. Although the risk of paracetamol-induced liver injury is much higher than in the kidneys, incidents of kidney damage by paracetamol should not be ignored, given the enormous cost of treating kidney diseases, particularly in resource-challenged developing nations. In an onerous quest for a cheaper and readily available antidote, this study examined the effect of Solanum anomalum fruit extract on paracetamol-induced kidney injuries and haemato-biochemical indices in rats. Twenty-five mature albino rats of both sexes were used, divided into five groups of five rats per group. Group 1 (normal control) rats were given distilled water (10ml/kg) for 8 days, group 2 (negative control) given distilled water (10 ml/kg) for 8 days, group 3 (positive control) given 100 mg/kg Silymarin for 8 days, group 4 given 452 mg/kg of S. anomalum fruit extract for 8 days, and group 5 given 678 mg/kg of S. anomalum fruit extract for 8 days. Thereafter, 2.0 g/kg of paracetamol was administered to groups 2-5 orally on the 8th day. Rats in group 2 showed significant increases in urea, creatinine, sodium ion, total WBCs, decrease in PCV, Hb concentration and RBCs. Administration of Solanum anomalum fruit extract significantly reversed most of these biomarkers. Histopathology of the kidneys also points to the mitigating effect of Solanum anomalum fruit against paracetamol-induced nephrotoxicity.

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Isolation and characterization of bioactive xanthones from Hippocratea africana (Willd.)Loes.ex Engl. (Celastraceae)

Cited by 11 publications

References 21 publications

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

A Review on the Cytotoxic and Antimicrobial Properties of Xanthones from Cratoxylum cochinchinense

Ameliorating Effects of Solanum anomalum Thonn. Ex. Schumach Fruit Extracts on Paracetamol-induced Kidney Injuries and Haemato-biochemical Indices in Rats

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