Isolation and characterization of a novel CXC chemokine in common carp (Cyprinus carpio L.)

The interferon system of teleost fish

“…Guanylate-binding protein, which is a major IFN-g induced antiviral protein in mammals, has also recently been cloned from rainbow trout and Atlantic salmon (Robertsen and co-workers, unpublished). Furthermore, several putative IFN-g inducible CXC chemokines have been cloned from fish [126,127]. It will be interesting to learn how IFN-g regulates the transcription of these genes in teleost fish.…”

Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish

“…Unlike their counterparts in higher vertebrates, the fish CXCL8 homologues mostly lack the ELR motif at the N terminus of the mature peptide, with the exception of gadoid CXCL8_L1 molecules, as seen in Atlantic cod and haddock (Corripio-Miyar et al, 2007;Seppola et al, 2008). Homologues have also been described for the CXCL9-11 group in carp, catfish, rainbow trout and zebrafish, whereas their phylogenetic relationship within the CXCL9-11 group has not been conclusively established (Nomiyama et al, 2008;Baoprasertkul et al, 2004;Chen et al, 2010;Savan et al, 2003). In contrast, the existence of CXCL12, 13 and 14 homologues in teleost fish is much more certain, as documented by several research groups (Baoprasertkul et al, 2004;Huising et al, 2004;Tian et al, 2010).…”

Identification, cloning and characterization of interleukin-17 and its family from zebrafish

“…These molecules are known to play a significant role in immuno-regulation and have potential application in the treatment of fish diseases. Till now a number of cytokines like IL-1b [1,2], IL-2 [3], IL-6 [4], IL-8 [5e9], IL-10 gene family [10e13], IL-11 [14], IL-12 [15], IL-18 [16], TNF's [17e19], interferons [11,13,20,21], CC and CXC chemokines [22,23] have been identified in fish. Among the cytokines, the major ones still to be identified in fish are IL-3 and T H 1 cytokines (IL-4, IL-5, IL-13 and IL-17).…”