Isolation and Biological Effects of 7-O-Methyleriodictyol, a Flavanone Isolated fromArtemisia monosperma, on Rat Isolated Smooth Muscles

Abstract

The isolation for the first time from the genus Artemisia (Compositae) of the known flavanone, 7-O-methyleriodictyol (7-methoxy-5,3',4'-trihydroxy-flavanone), its identification, and its biological effects on rat isolated smooth muscles are described. 7-O-Methyleriodictyol (10(-7) M to 3 x 10(-4) M) caused concentration-dependent inhibition of the amplitude of the phasic contractions and reduced the tone of the ileum, the uterus, and the urinary bladder. It also caused relaxation of the phenylephrine-precontracted pulmonary artery and the acetylcholine-precontracted trachea. The flavanone also shifted to the right the acetylcholine concentration-effect curve on the ileum and the oxytocin concentration-effect curve on the uterus. The maximum contractions induced by acetylcholine or oxytocin were also inhibited by 7-O-methyleriodictyol. These antispasmodic effects are partly consistent with the use of A. monosperma in folk medicine for certain gastrointestinal disorders.

Effects of Artemisia monosperma ethanolic leaves extract on implantation, mid-term abortion and parturition of pregnant rats

“…These results may cause irritation and stretch of uterine cervix (neurogenic reflex), which may stimulate the posterior pituitary gland to increase its secretion of OT (Guyton, 2006). In another area of in vitro studies, it was reported that Artemisia monosperma extract, exerted a relaxant effect of uterine smooth muscle and inhibited the contraction of the uterus that induced by oxytocin (Abu-Niaaj et al, 1993).…”

“…Artemisia monosperma reported to contain several phytochemicals such as volatile oil (Saleh, 1985), flavonoids (Ismail et al, 1989;Abu-Niaaj et al, 1993;Elgamal et al, 1997), alkaloids (Zaki et al, 1984) and coumarins (Hammoda et al, 2008). Coumarins are known to inhibit mail fertility (Ray et al, 1991) and to inhibit under the number: A9864 at the Herbarium of Jordan University.…”

Chemical Profile and Biological Activities of Essential oil of Aerial parts of Artemisia monosperma Del. Growing in Libya

“…insecticidal, 9 anti-malarial 10 and anticancer activities. 11 Various types of secondary metabolites were reported in A. monosperma plants from different localities including: coumarins, 12,13 flavonoids, [14][15][16] acetylenes, 9,17,18 alkaloids, 19 sesquiterpenoids 20 and triterpenoids. 16 However, nothing could be traced in the available literature concerning either the constituents or biological activities of the plant growing in Libya.…”

Evaluation of Antispasmodic Effect of Arcapillin on Smooth Muscles of Rats

“…Flavonoids are bioactive compounds with a wide spectrum of biological activities including their effects on smooth muscles. 8,15,16,29,30 Artemisia monosperma is a good source of flavonoids and is reputed in folk medicine in the Middle East for the relief of abdominal illness, inflammation and for inducing labor. Several flavonoids isolated from A. monosperma were reported to induce relaxation of different rat smooth muscles.…”

“…1 Different extracts of A. monosperma exhibited a wide spectrum of biological actions such as muscle relaxation, [6][7][8] antidiabetic, 1,8 and antimicrobial activities. [9][10][11][12][13][14] Bioactive compounds isolated from Artemisia species showed antispasmodic, 15,16 antihypertensive, 17 antimicrobial, 12,13 insect repellents, [18][19][20] antitumor and anti-inflammatory activities. [21][22][23] Arcapillin was first identified from A. capillaris 24 and it was reported an antihepatotoxic.…”