Isolation and antitrichomonal activity of the chemical constituents of the leaves of Maytenus phyllanthoides Benth. (Celastraceae)

Moo-Puc, Juan Alberto; Martín-Quintal, Zhelmy; Mirón-López, Gumersindo; Moo‐Puc, Rosa; Quijano, Leovigildo

doi:10.1590/s0100-40422014000100016

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…In this work ciclocytic stomata were found in M. imbricata whereas anomoctic stomata were reported for M. aquifolia and M. ilicifolia (Jacomassi & The presence of pores in the wall of epidermal cells and the occurrence of guard cells arranged in rosette and subsidiary cells positioned below the surface in M. imbricata have been reported for other species of Celastraceae (Metcalfe & Chalk 1957). However, strips on the epidermal cell wall are reported for the first time for Maytenus and their role in the control of water traffic in apoplast is well recognized (Moreira & Isaias 2008, Yang et al 2011.…”

Section: Discussionmentioning

confidence: 62%

“…Many of the chemical components isolated from its species have pharmacological properties (Din et al 2013, Duarte et al 2013, Moo-Puc et al 2014 (Silva et al 2009, Rodrigues et al 2012, M. aquifolium Mart., (Gonzalez et al 2001), M. salicifolia Reissek, (Magalhães et al 2011) and M. truncata Reissek, (Silva et al 2005a) are used in folk medicine to treat the same stomach illness, and have the same popular name "espinheira-santa" (Niero et al 2011). For these reasons it is necessary a careful quality control of raw material in the manufacture of drugs using Maytenus species and is required define anatomical key characters for the unambiguous species identification (Jacomassi & Machado 2004, Duarte & Debur 2005, Joffily & Vieira 2005, Nakamura et al 2013.…”

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confidence: 99%

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Leaf morphoanatomy of the medicinal <em>Maytenus imbricata</em> (Celastraceae): an ecological approach

et al. 2017

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Background: The leaves of many species of Maytenus are used to prepare herbal drugs to treat stomach ulcers. Questions: In order to define key anatomical characters for the unambiguous species identification, the present study aimed to describe the leaf morphoanatomy of M. imbricata. Species study: Maytenus imbricata Mart. ex Reissek (Celastraceae) Study site and dates: Collected in an area of 'campo rupestre' -one of the Brazilian Savannah vegetation (20º 22' 11.02" S, 43º 30' 22.81" W) in August 2015. Methods: The plant material was processed according to commonly used techniques in plant anatomy studies. Results: The major anatomical characters for several species of Maytenus identification also present in M. imbricata are marginal teeth, conspicuous epicuticular wax, ciclocytic stomata, thick external periclinal wall with large pits on epidermal cells and vascular system with a closed loop shape in cross-section. Strips on the anticlinal walls on epidermal cells and conspicuous gelatinous fibers sheath are diagnostic for M. imbricata. Conclusions: Strips on the anticlinal wall of the epidermal cell are reported for the first time for the genus. The xeromorphic traits help the species to survive in arid environments and may contribute to quality control of the raw material used in the production of herbal medicines. Keywords: cell wall strips, colleter, gelatinous fiber, xeromorphic. ResumenAntecedentes: Las hojas de muchas especies de Maytenus se utilizan para la preparación de medicamentos para el tratamiento de las úlceras de estómago. Preguntas: Con la finalidad de contribuir a la identificación de la especie, este estudio tuvo como objetivo describir la morfología y anatomia de la hoja de M. imbricata. Especie de estudio: Maytenus imbricata Mart. ex Reissek (Celastraceae) Sitio y años de estudio: Recolecta de material en una zona de 'campo rupestre' -vegetación del cerrado brasileño (20º 22' 11.02" S, 43º 30' 22.81" W) en agosto del 2015. Métodos: El material vegetal se procesó mediante las técnicas que se utilizan en los estudios de anatomía vegetal. Resultados: Los principales caracteres anatómicos para la identificación de varias especies de Maytenus, que están presentes en M. imbricata, son los dientes marginales, la cera epicuticular gruesa, los estomas ciclocíticos, las células epidérmicas con la pared periclinal externa gruesa, con grandes punteaduras y la sección transversal del sistema vascular en un círculo cerrado. Las estrías en las paredes anticlinales y las fibras gelatinosas son caracteres diagnósticos para M. imbricata. Conclusiones: Las estrías que se forman en la pared de las células epidérmicas se reportan por primera vez en el género. Estos caracteres xeromórficos ayudan a la especie a sobrevivir en ambientes áridos y pueden contribuir al control de la calidad de la materia prima utilizada en la producción de medicamentos. Palabras clave: caracteres xeromórficos, coléteres, estrías en la pared celular, fibras gelatinosas.

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Section: Discussionmentioning

confidence: 62%

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confidence: 99%

Leaf morphoanatomy of the medicinal <em>Maytenus imbricata</em> (Celastraceae): an ecological approach

et al. 2017

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“…Several members of this genus are used in traditional medicine to treat cancer [ 2 ], gastric ulcers [ 3 ], and arthritis [ 4 ]. Maytenus species are known to contain a diverse group of triterpenoids [ 5 , 6 , 7 ], flavonoids [ 8 , 9 ], tannins [ 10 ], lignans [ 11 , 12 ], dihydro-β-agarofurans [ 4 , 13 , 14 ] and sesquiterpene pyridine alkaloids [ 15 , 16 , 17 ] that display remarkable structural diversities and cytotoxicity [ 18 , 19 , 20 , 21 , 22 ], as well as insecticidal [ 23 ], antitumor-promoting [ 13 ], MDR-reverting [ 24 , 25 , 26 ], antitubercular [ 27 ], neuroprotective [ 28 ], immunosuppressive [ 29 ], anti-HIV [ 30 ], anti-inflammatory [ 18 ], and medicinal properties [ 3 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Identification of Phytocompounds from Maytenus dhofarensis and Their Biological Potentials

Al-Rubaiai,

Al-Shariqi,

Al-Shabibi

et al. 2023

Molecules

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Maytenus dhofarensis Sebsebe (Celestraceae) is a naturally growing shrub in Oman. It is not a reputed medicinal plant in Oman, but it is regionally endemic and causes shivering attacks on goats that graze on it. The chemical investigation of the hexane and chloroform extracts of the fruits and stems of M. dhofarensis afforded dihydro-β-agarofuran-type sesquiterpene pyridine alkaloid (1), lupanyl myristoate (2) and lignanolactone (3). Compounds (1–3) are new isolates from M. dhofarensis. The structures of these compounds were assigned through comprehensive IR, NMR, and ESI-MS analyses, and the relative configurations of compounds 1 and 3 were deduced from density function theory (DFT) calculations and NMR experiments. Compound 1 was assayed against the kinase enzyme and showed no inhibition activity for p38 alpha and delta at a 10 µM test concentration. Compound 3 inhibited the 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH) by 69.5%, compared to 70.9% and 78.0% for gallic acid and butylated hydroxyanisole, respectively, which were used as positive controls.

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“… 2013 ) and antitrichomonal activity (Moo-PucI et al. 2014 ). Aglycones are more lipophilic compounds than its parent glycosides.…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of lignan glycoside to its aglycone by Woodfordia fruticosa flowers: quantification of compounds using a validated HPTLC method

Mishra

Aeri

2016

Pharmaceutical Biology

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Context:Saraca asoca Linn. (Caesalpiniaceae) is an important traditional remedy for gynaecological disorders and it contains lyoniside, an aryl tetralin lignan glycoside. The aglycone of lyoniside, lyoniresinol possesses structural similarity to enterolignan precursors which are established phytoestrogens.Objectives: This work illustrates biotransformation of lyoniside to lyoniresinol using Woodfordia fruticosa Kurz. (Lythraceae) flowers and simultaneous quantification of lyoniside and lyoniresinol using a validated HPTLC method.Materials and methods: The aqueous extract prepared from S. asoca bark was fermented using W. fruticosa flowers. The substrate and fermented product both were simultaneously analyzed using solvent system:toluene:ethyl acetate:formic acid (4:3:0.4) at 254 nm. The method was validated for specificity, accuracy, precision, linearity, sensitivity and robustness as per ICH guidelines.Results: The substrate showed the presence of lyoniside, however, it decreased as the fermentation proceeded. On 3rd day, lyoniresinol starts appearing in the medium. In 8 days duration most of the lyoniside converted to lyoniresinol. The developed method was specific for lyoniside and lyoniresinol. Lyoniside and lyoniresinol showed linearity in the range of 250–3000 and 500–2500 ng. The method was accurate as resulted in 99.84% and 99.83% recovery, respectively, for lyoniside and lyoniresinol.Conclusion: Aryl tetralin lignan glycoside, lyoniside was successfully transformed into lyoniresinol using W. fruticosa flowers and their contents were simultaneously analyzed using developed validated HPTLC method.

show abstract

Isolation and antitrichomonal activity of the chemical constituents of the leaves of Maytenus phyllanthoides Benth. (Celastraceae)

Cited by 10 publications

References 22 publications

Leaf morphoanatomy of the medicinal <em>Maytenus imbricata</em> (Celastraceae): an ecological approach

Leaf morphoanatomy of the medicinal <em>Maytenus imbricata</em> (Celastraceae): an ecological approach

Isolation and Identification of Phytocompounds from Maytenus dhofarensis and Their Biological Potentials

Biotransformation of lignan glycoside to its aglycone by Woodfordia fruticosa flowers: quantification of compounds using a validated HPTLC method

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