Isolation and antimutagenic activity of some flavanone compounds from Kaempferia rotunda

Atun, Sri; Arianingrum, Retno; Sulistyowati, Eddy; Aznam, Nurfina

doi:10.1016/j.ijcas.2013.03.004

Cited by 22 publications

(17 citation statements)

References 9 publications

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“…This data shows that the compound is pinostrobin (5-hydroxy-7-methoxy-flavanones) with the structure as in Figure 4. The compounds have previously been found in K. rotunda rhizome [5]. Antioxidant activity assay for the sample ethanol extract, pure compound, and ascorbic acid (positive control) were indentified using DPPH method.…”

Section: Resultsmentioning

confidence: 99%

“…The extract Boesenbergia pandurata very effectively kills pathogenic bacteria C. albicans in vitro [3,4]. Previous research showed some secondary metabolites such as pinostrobin, pinocembrin, cardamonin, panduratin, and alpinetin [1,5,6]. The biological activity of these compounds showed as anti-tumor, anti-cancer, anti-oxidant, and anti-inflammatory.…”

Section: Introductionmentioning

confidence: 99%

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Identification and antioxidant activity test of bioactive compound produced from ethanol extract of temukunci (Boesenbergia rotunda)

Atun¹,

Handayani²,

Frindryani³

2017

AIP Conference Proceedings

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification and antioxidant activity test of bioactive compound produced from ethanol extract of temukunci (Boesenbergia rotunda)

Atun¹,

Handayani²,

Frindryani³

2017

AIP Conference Proceedings

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“…These flavanones can be extracted from the rhizomes of fingerroot ( Boesenbergia rotrunda ) and galangal ( Alpinia galangal and A. officinarum ) as well as many other herbal plants mostly found in Southeast Asia. PNS has several important biological activities, such as an anti-viral role with the herpes simplex virus-1 [ 4 ], anti-mutagenic activity [ 5 ], anti-fungal effects for Cytospora persoonii [ 6 ] and anti-malarial activity [ 7 ]. It plays a major role in anti-ulcer activity that could be indirectly a result of its anti-oxidant mechanism [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Theoretical and Experimental Studies on Inclusion Complexes of Pinostrobin and β-Cyclodextrins

et al. 2018

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Pinostrobin (PNS) belongs to the flavanone subclass of flavonoids which shows several biological activities such as anti-inflammatory, anti-cancerogenic, anti-viral and anti-oxidative effects. Similar to other flavonoids, PNS has a quite low water solubility. The purpose of this work is to improve the solubility and the biological activities of PNS by forming inclusion complexes with β-cyclodextrin (βCD) and its derivatives, heptakis-(2,6-di-O-methyl)-β-cyclodextrin (2,6-DMβCD) and (2-hydroxypropyl)-β-cyclodextrin (HPβCD). The AL-type diagram of the phase solubility studies of PNS exhibited the formed inclusion complexes with the 1:1 molar ratio. Inclusion complexes were prepared by the freeze-drying method and were characterized by differential scanning calorimetry (DSC). Two-dimensional nuclear magnetic resonance (2D-NMR) and steered molecular dynamics (SMD) simulation revealed two different binding modes of PNS, i.e., its phenyl- (P-PNS) and chromone- (C-PNS) rings preferably inserted into the cavity of βCD derivatives whilst only one orientation of PNS, where the C-PNS ring is inside the cavity, was detected in the case of the parental βCD. All PNS/βCDs complexes had a higher dissolution rate than free PNS. Both PNS and its complexes significantly exerted a lowering effect on the IL-6 secretion in LPS-stimulated macrophages and showed a moderate cytotoxic effect against MCF-7 and HeLa cancer cell lines in vitro.

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“…are also edible or ornamental plants (Saensouk & Jenjittikul, ; Chuakul & Boonpleng, ; Picheansoonthon & Koonterm, ). Kaempferia galanga , K. marginata , K. parviflora , K. pulchra and K. rotunda are valuable sources of bioactive compounds, such as essential oils, diterpenoids and flavonoids (Sematong et al, ; Sookkongwaree et al, ; Azuma et al, ; Atun et al, ). Essential oils from numerous plant species are also used in aromatherapy treatment (Hardy et al, ; Lis‐Balchin & Hart, ; Bakkali et al, ).…”

Section: Introductionmentioning

confidence: 99%

Chromosome number variation and polyploidy in 19 Kaempferia (Zingiberaceae) taxa from Thailand and one species from Laos

Nopporncharoenkul

Chanmai

Jenjittikul

et al. 2017

J of Sytematics Evolution

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Several Kaempferia species, endemic to Thailand, are rare and therefore entitled to conservation status; other species are widely cultivated. We conducted extensive cytogenetic investigation of this genus to elucidate the botanical and taxonomic characterization of these plants. The study included 42 accessions belonging to 15 Kaempferia species and four undescribed taxa from regions throughout Thailand, and one species from Laos. We determined chromosome numbers from root‐tip cells collected from germinating rhizomes ex situ, but examined meiosis in flowers collected from the wild. The mitotic analyses verify that 2n chromosome numbers range from 22 (diploid, 15 taxa), 33 (triploid, three species), 44 (tetraploid, five taxa) to 55 (pentaploid, one species). Four taxa included accessions with different ploidy levels. The meiotic analyses demonstrated that all 14 diploid accessions investigated displayed normal meiosis, forming 11 bivalents, indicating the base chromosome number x = 11 for this genus. Meiotic figures were obtained from one triploid and four tetraploid accessions. The triploid showed 11 trivalents, most likely indicating autotriploidy. Two tetraploid accessions showed regular meiotic figures consisting of 22 bivalents, probably indicating allopolyploidy originating from interspecific hybrids, a hypothesis that is consistent with observations of plant morphology. The other two tetraploid accessions belong to the same species and show mostly irregular meiotic figures. Cytogenetic information is useful for evaluating fertility and hybridity in the genus. Good seed set was observed among diploid and tetraploid accessions. Triploid and pentaploid plants, on the other hand, do not set seeds, but produce large clusters of vegetatively‐propagated rhizomes.

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Isolation and antimutagenic activity of some flavanone compounds from Kaempferia rotunda

Cited by 22 publications

References 9 publications

Identification and antioxidant activity test of bioactive compound produced from ethanol extract of temukunci (Boesenbergia rotunda)

Identification and antioxidant activity test of bioactive compound produced from ethanol extract of temukunci (Boesenbergia rotunda)

Theoretical and Experimental Studies on Inclusion Complexes of Pinostrobin and β-Cyclodextrins

Chromosome number variation and polyploidy in 19 Kaempferia (Zingiberaceae) taxa from Thailand and one species from Laos

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