Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity

Arslan, Müyesser Saykı; Topaloğlu, Oya; Uçan, Bekir; Karaköse, Melia; Karbek, Başak; Tutal, Esra; Çalışkan, Mustafa; Giniş, Zeynep; Çakal, Erman; Şahi̇n, Mustafa; Delibaşı, Tuncay

doi:10.1155/2015/239815

Cited by 14 publications

(11 citation statements)

References 20 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are several studies suggesting that the prevalence of vit-D deficiency is high in patients with HT and that there is a relationship between hypothyroidism and vit-D in these patients [16]. In our study, we found that 96% of patients with HT had vit-D deficiency, and 56.1% of patients had severe vit-D deficiency (<10 ng/mL).…”

Section: Discussionsupporting

confidence: 54%

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Aktaş

2019

Med Princ Pract

View full text Add to dashboard Cite

Background: This study was designed to investigate the vitamin D (vit-D) and vitamin B12 (vit-B12) levels and their correlation with anti-thyroid peroxidase (anti-TPO) antibodies in patients with autoimmune hypothyroidism. Methods: A total of 130 patients diagnosed with autoimmune hypothyroidism were included in the study retrospectively. The patients were divided into two groups as those having vit-B12 levels below 200 pg/mL (n = 60) and vit-B12 levels equal to or above 200 pg/mL (n = 70). These two groups were compared in terms of age, sex, thyroid-stimulating hormone (TSH), free-T4 (FT4), vit-D, and anti-TPO. The correlation between vit-B12 and anti-TPO levels was also investigated in these groups. Patients were then divided into four groups according to their vit-D levels. Patients with normal vit-D levels (25[OH]D >30 ng/mL; n = 5), those with vit-D insufficiency (20–30 mg/mL; n = 9), those with vit-D deficiency (10–20 ng/mL; n = 43), and those with severe vit-D deficiency (<10 ng/mL; n = 73). These four groups were compared in terms of age, gender, TSH, FT4, vit-B12, and anti-TPO levels. In addition, the correlation between levels of vit-D and anti-TPO was also investigated. Results: We found that vit-B12 deficiency and vit-D deficiency were associated with autoimmune hypothyroidism, and that there was a negative correlation between vit-B12 and vit-D levels and anti-TPO antibodies in these patients. Conclusion: In patients with autoimmune hypothyroidism, vit-D and vit-B12 deficiency should be investigated at the time of diagnosis and periodically on follow-ups.

show abstract

Section: Discussionsupporting

confidence: 54%

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Aktaş

2019

Med Princ Pract

View full text Add to dashboard Cite

show abstract

“…Allelic variants of the vitamin D - binding protein (DBP) gene enhance susceptibility to Graves’ disease but not to Hashimoto’s thyroiditis, which expresses the endocrine role of vitamin D [ 10 ]. In contrast to this, some studies proposed an association between vitamin D deficiency and Hashimoto’s thyroiditis where a higher prevalence of vitamin D deficiency was reported among these patients [ 11 ] [ 12 ] [ 13 ]. At the same time, a significantly higher prevalence of vitamin D deficiency has been reported among patients with autoimmune thyroid disorders, hypothyroidism, overt hypothyroidism and Graves’ disease [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Thyroid Function and 25 (OH) Vitamin D Level among Sudanese Women in Early Pregnancy

Musa¹,

Rayis²,

Ahmed³

et al. 2018

Open Access Maced J Med Sci

View full text Add to dashboard Cite

AIM:A cross-sectional study was conducted at Saad Abualila Hospital (Khartoum, Sudan) to evaluate the vitamin D levels and thyroid function among pregnant Sudanese women (132) in early pregnancy.METHODS:A cross-sectional study was conducted at Saad Abualila hospital (Khartoum, Sudan) during the period from March to July 2015. Women who were in early pregnancy with a singleton pregnancy were approached to participate in the study after signing informed consent. A sample size of 132 participants was calculated guided by the normal interval of thyroid function in Sudanese women in the first trimester and not the level of 25(OH) vitamin D. The 25 - hydroxyvitamin D (25 (OH) vitamins levels were measured using an electrochemiluminescence immunoassay on an Elecsys 2010 Analyzer (Roche Diagnostics, Mannheim, Germany).RESULTS:The mean (SD) of age, gravidity and gestational age was 27.6 (5.5) years, 2.2 (1.6) and 10.4 (2.2) weeks, respectively. The mean (SD) of the body mass index (BMI) and haemoglobin was 27.1 (5.2) kg/m2 and 10.8 (1.1) g/dl, respectively. Median (interquartile) values of TSH, FT3, and FT4 were 1.164 IU/ml (0.079 -2.177 IU/ml), 4.639 nmol/l (3.843 - 6.562 nmol/l), and 16.86 pmol/l (13.02 - 31.48 pmol/l), respectively. There was no significant correlation between vitamin D levels and TSH, FT3 and FT4CONCLUSION:There is no correlation between 25 (OH) vitamin D levels and thyroid function during early pregnancy among Sudanese pregnant women, despite prevalent vitamin D deficiency among these women.

show abstract

“…Bozkurt et al reported a correlation between 25(OH)D deficiency severity, duration of HT, thyroid volume, and antibody titers [ 52 ]. An inverse correlation between 25(OH)D and anti-TPO was also verified by Giovinazzo et al in recently diagnosed euthyroid HT patients vs. control subjects [ 56 ]; by Arslan et al in healthy subjects with moderate–severe 25(OH)D deficiency [ 65 ]; and by Shin et al in individuals with AITD [ 66 ]. Goswami et al detected only a weak correlation between the levels of 25(OH)D and anti-TPO [ 67 ].…”

Section: Vitamin D and Autoimmune Thyroid Diseasementioning

confidence: 64%

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vieira¹,

Rodrigues

Paiva³

2020

Nutrients

View full text Add to dashboard Cite

Vitamin D is a steroid hormone traditionally connected to phosphocalcium metabolism. The discovery of pleiotropic expression of its receptor and of the enzymes involved in its metabolism has led to the exploration of the other roles of this vitamin. The influence of vitamin D on autoimmune disease—namely, on autoimmune thyroid disease—has been widely studied. Most of the existing data support a relationship between vitamin D deficiency and a greater tendency for development and/or higher titers of antibodies linked to Hashimoto’s thyroiditis, Graves’ disease, and/or postpartum thyroiditis. However, there have also been some reports contradicting such relationships, thus making it difficult to establish a unanimous conclusion. Even if the existence of an association between vitamin D and autoimmune thyroid disease is assumed, it is still unclear whether it reflects a pathological mechanism, a causal relationship, or a consequence of the autoimmune process. The relationship between vitamin D’s polymorphisms and this group of diseases has also been the subject of study, often with divergent results. This text presents a review of the recent literature on the relationship between vitamin D and autoimmune thyroid disease, providing an analysis of the likely involved mechanisms. Our thesis is that, due to its immunoregulatory role, vitamin D plays a minor role in conjunction with myriad other factors. In some cases, a vicious cycle is generated, thus contributing to the deficiency and aggravating the autoimmune process.

show abstract

Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity

Cited by 14 publications

References 20 publications

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Thyroid Function and 25 (OH) Vitamin D Level among Sudanese Women in Early Pregnancy

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Contact Info

Product

Resources

About