Thyroid Function and 25 (OH) Vitamin D Level among Sudanese Women in Early Pregnancy

Musa, Imad R.; Rayis, Duria A.; Ahmed, Mohmamed A.; Khamis, Ammar H.; Nasr, Abubakr M.; Adam, Ishag

doi:10.3889/oamjms.2018.125

Cited by 8 publications

(7 citation statements)

References 41 publications

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“…This was confirmed by similar results in a transgenic mouse model, with mice over-expressing the human vitamin D receptor in renin-producing cells that were suppressed with the administration of 1,25-dihydroxyvitamin D3, independent of parathyroid hormone and calcium levels [46] . The results of the present study are in concordance with the outcomes of many studies that have shown no significant associations between vitamin D and other associated predictors (age, gender, BMI, thyroid hormone levels, hypothyroidism and hyperthyroidism [28,[47][48][49][50][51] . This may be explained by the very high prevalence of vitamin D deficiency in patients with thyroid nodules in the present study (89.8%), which confirms the results of a previous study from Saudi Arabia [49] .…”

Section: Discussionsupporting

confidence: 92%

Prevalence of Vitamin D Deficiency and the Associated Risk Factors in Adults with Thyroid Nodule in Royal Commission Hospital, Kingdom of Saudi Arabia

Alyousif

Alamin

Ahmed

et al. 2022

ijirms

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Vitamin D is an essential nutrient for the human body. Its deficiency is linked with many common chronic diseases, types of cancer and thyroid disorders. Recent data have shown high rates of vitamin D deficiency, thyroid nodules and an increase in the incidence of thyroid cancer in the Kingdom of Saudi Arabia (KSA). We conducted this study to evaluate the rates of vitamin D deficiency and associated risk factors in patients with thyroid nodules in the Eastern Region of the KSA. Methods: A retrospective study was conducted between 1 January 2015 and 31 December 2021. The recruited patients had documented thyroid nodules based on the American College of Radiology’s Thyroid Imaging Reporting and Data System (TI-RADS). Results: There were 391 patients with thyroid nodules enrolled in the study. The median (interquartile range [IQR]) age was 46.00 (20.0) years, and 332 (84.9%) of the participants were women. The patients’ median (IQR) body mass index was 30.26 (7.71) kg/m2, and the median (IQR) 25-hydroxyvitamin D (25[OH)]D) level was 14.50 (12.0) nmol/L. There was a high prevalence (89.8%) of vitamin D deficiency among patients with thyroid nodules. In the univariate analysis, there were significant associations between 25(OH)D level and age, hypertension, hyperthyroidism, thyroid-stimulating hormone level, free triiodothyronine level and thyroid ultrasound-based TI-RADS scores of 3 to 5. In the multivariate analysis, age, free thyroxine level, free triiodothyronine level and hyperthyroidism were not significantly associated with 25(OH)D level. However, there were significant associations between 25(OH)D level and hypertension (odds ratio [OR]=0.438, 95% confidence interval [CI] 0.210‒0.911) and higher TI-RADS scores (TI-RADS 4: OR=9.654 [95% CI 1.819‒51.226] and TI-RADS 5: OR=7.784 [95% CI 1.473‒41.135]). Conclusion: There was a high prevalence of vitamin D deficiency among patients with nodular thyroid disease. TI-RADS ultrasound scores of 4 and 5 and the presence of hypertension were significantly associated with lower levels of vitamin D.

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Section: Discussionsupporting

confidence: 92%

Prevalence of Vitamin D Deficiency and the Associated Risk Factors in Adults with Thyroid Nodule in Royal Commission Hospital, Kingdom of Saudi Arabia

Alyousif

Alamin

Ahmed

et al. 2022

ijirms

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“…Previous studies have confirmed the same findings. A study by Musa et al showed that there is no clear relationship between thyroid function and vitamin D[25]OH in pregnant women [ 36 ]. Zhao et al showed that there was no significant relationship between serum vitamin D levels and thyroid parameters [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study

Ahi

Adelpour

Fereydooni

et al. 2022

International Journal of Endocrinology

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Background. The aim of this study was to evaluate the prevalence of vitamin D deficiency in pregnant women to investigate the relationship between vitamin D level and thyroid function. Methods. In this cross-sectional descriptive study, a total number of 66 patients during the three trimesters of pregnancy were investigated; 22 pregnant women were studied in each trimester of pregnancy. We evaluated thyroid function tests and thyroid autoantibodies (TPOAb and TGAb), as well as the serum level of 25OHD, to determine the relationship between vitamin D level and autoimmune or non-autoimmune thyroid disease in pregnancy. Results. Pearson’s correlation in all subjects showed that vitamin D levels did not have a significant relationship with maternal age. Only in the third trimester, there was a significant difference in maternal age based on their vitamin D status. There was no significant difference between the trimesters of pregnancy and vitamin D status ( P > 0.05 ). Also, there were no significant differences between serum levels of vitamin D within three trimesters. Examination of thyroid function tests during pregnancy in relation to vitamin D showed that there was no significant Spearman’s correlation between thyroid function status and serum vitamin D level ( P > 0.05 ). There was no significant difference in the mean level of serum 25OH vitamin D in each subgroup of thyroid status ( P > 0.05 ). Regarding the pregnancy outcomes, two newborns were admitted to NICU, meconium aspiration was in one case, and IUFD in another case led to pregnancy termination. These four cases were related to the maternal history of hypothyroidism. Conclusion. There was no significant relationship between vitamin D and pregnancy trimester. The serum level of vitamin D had no particular effect on the outcome of pregnancy and the thyroid gland function.

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“…In the present study, the TSH levels are not dependent on the vitamin D supplementation and when compared with age and BMI, the TSH levels are not statistically significant after the vitamin D supplementation and these findings are in line with the previous studies. 13,14 table 3. Due to its activity in the thyroid gland and even in patients with thyroid disorders and thyroid autoantibody, several types of research have shown that vitamin D has an effect on thyroid hormone.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin – D Supplementation On Serum TSH Levels in Pregnant Women and Its Co Relation to Age and Body Mass Index.

Srilekha

Vijayalakshmi

Indla

2022

Int J Life Sci Pharm Res

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The main aim of the study is to investigate the association between vitamin D after insufficiency and thyroid hormone levels in pregnancy. The objective of the present study is to see how serum vitamin D levels are related to Thyroid stimulating hormone (TSH) during the first trimester of after pregnancy in relation to the age and BMI of the pregnant women. In this crosssectional study 100 pregnant women (50as control group, 50 as vitamin D supplementation group) are included and categorized as per their age and BMI. Vitamin D supplementation is done under the supervision of the gynecologist at the start of 1st trimester and at the end of the first-trimester, serum TSH levels are estimated in them. The mean was analysed by two-way ANOVA (Twoway analysis of variance with Bonferroni‘t’ test method). For all the statistics and graph plotting, SigmaPlot 13.0 (Systat software, USA) was used. P <0.05 is considered significant. The difference in the mean values among the different levels of the group is not significant enough to exclude the after possibility that the difference is just due to random sampling variability after allowing for the effects of differences in BMI Category. There is not a statistically significant difference (P = 0.506). According to the findings of this study, there is no correlation between vitamin D levels and TSH levels in relation to the age and BMI of pregnant women; therefore, more research should be done on groups of pregnant women divided by weeks of pregnancy and age, and vitamin D supplementation should be recommended.

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Thyroid Function and 25 (OH) Vitamin D Level among Sudanese Women in Early Pregnancy

Cited by 8 publications

References 41 publications

Prevalence of Vitamin D Deficiency and the Associated Risk Factors in Adults with Thyroid Nodule in Royal Commission Hospital, Kingdom of Saudi Arabia

Prevalence of Vitamin D Deficiency and the Associated Risk Factors in Adults with Thyroid Nodule in Royal Commission Hospital, Kingdom of Saudi Arabia

Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study

Effect of Vitamin – D Supplementation On Serum TSH Levels in Pregnant Women and Its Co Relation to Age and Body Mass Index.

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