Isolated small intestinal atresias in Latin America and Spain: Epidemiological analysis

Abstract

Stenosis, atresia, or absence of part of the duodenum, jejunum, or ileum are generally considered small intestinal atresias (SIAs). SIAs occur as isolated defects, in combination with other unrelated congenital anomalies, or as part of syndromes. We performed an epidemiological study of infants with isolated SIAs using data from two large congenital defects registries, one from Latin America (ECLAMC) and the other from Spain (ECEMC). The overall prevalence of SIAs is similar in both programs, being 1.32 per 10,000 livebirths in Spain and 1.29 per 10.000 livebirths in Latin America. Our results suggest that infants with isolated SIAs are characterized epidemiologically on the basis of shorter gestational age and low birthweight, an association with twinning, the parents are more frequently consanguineous, and their pregnancies are more frequently complicated by vaginal bleeding. The results also suggest an association between some maternal infections and ileal atresia. The fact that these characteristics have been observed in children with these types of anomalies occurring in different geographical areas and populations supports the conclusion that these characteristics are causally related to these defects.

Etiological Spectrum of Neonates Presenting With Intestinal Obstruction at A Tertiary Care Centre

“…It can occur at any age from new born period to infants or even adulthood. The reported frequency of NIO ranges from 0.4 to 3.1/10,000 live births (1)(2)(3)(4)(5) . the etiology of obstruction varies greatly; with common aetiologies such as intestinal atresia, meconium ileus, hirschsprung disease and malrotation of gut with or without volvulus (6) .…”

Epidemiology of small intestinal atresia in Europe: a register-based study

“…Of those that have, the reported prevalence rates range from 1.3 to 2.9 per 10 000 live births 4 5. Estimates of the prevalence of duodenal atresia range from 0.7 to 1.8 per 10 000 total births 6 7.…”

Prenatal Intestinal Obstruction Affects the Myenteric Plexus and Causes Functional Bowel Impairment in Fetal Rat Experimental Model of Intestinal Atresia

“…In jejuno-ileal atresia, the obstruction is commonly related to a fetal vascular event secondary to mesenteric ischemia, intestinal volvulus, intussusception or strangulation [2], [3]. Genetic factors are not involved, except in rare syndromic forms [4], [5]. Surgical repair is necessary soon after birth, because of the obstructive consequences, and usually consists of gut resection-anastomosis.…”