Isolated primary tuberculosis of spleen—A rare entity in the immuno-competent patient

Kumar, Suneed; Pai, Ajay G.; Tungenwar, Pravin N.; Bhandarwar, Ajay H.

doi:10.1016/j.ijscr.2016.11.038

Cited by 10 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spleen might be involved in the course of TB as an isolated involvement or being secondary to miliary TB. Although there are few studies that have reported isolated splenic TB in immunocompetent cases, 4,5 usually, a congenital or acquired immunodeficiency is a predisposing factor. There are few studies that report HIV infection, diabetes mellitus, organ transplantation, and immunosuppressive therapy as the risk factors of splenic TB.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

First Report of an Association Between Crohn’s Disease and Isolated Splenic Tuberculosis in Pediatric Population

Sayyahfar

Motamedi

Rahbar

2022

Middle East J Dig Dis

View full text Add to dashboard Cite

Isolated splenic tuberculosis (TB) in children is extremely rare, and congenital or acquired immunodeficiency is usually a predisposing factor for this disease. Herein, we report a case of isolated splenic TB in a 5.5-year-old child associated with Crohn’s disease. As far as we are aware, this association is reported for the first time in children. Clinicians should be aware and consider extra pulmonary TB, especially in endemic regions. In addition, evaluation of an underlying disorder in unusual presentations of TB is advisable.

show abstract

Section: Discussionmentioning

confidence: 99%

“…5,6,9 Other manifestations are malaise, weight loss, vague abdominal pain, and abdominal distention. 4,6,9,10 The most prevalent sign is splenomegaly.…”

Section: Discussionmentioning

confidence: 99%

First Report of an Association Between Crohn’s Disease and Isolated Splenic Tuberculosis in Pediatric Population

Sayyahfar

Motamedi

Rahbar

2022

Middle East J Dig Dis

View full text Add to dashboard Cite

show abstract

“…Splenic TB can be classified into five pathomorphological types: miliary, nodular, spleen abscess, calcific, and mixed type. Among these, the spleen abscess is the most common and typically presents with the most symptoms [7]. The clinical presentation of splenic TB can often be vague and nonspecific, which frequently leads to delayed diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Isolated Splenic Tuberculosis Presenting as a Splenic Abscess Complicated by Rupture Leading to Splenectomy in an Immunocompetent Male

Ranjan,

Rai,

Gunasekaran

et al. 2024

Cureus

View full text Add to dashboard Cite

We report a rare case of splenic tuberculosis (TB) in a male patient with a competent immune system who had no previous record of pulmonary TB. A 56-year-old male patient came to our outpatient department complaining of upper abdominal pain with a few episodes of vomiting for three days. He had alcoholism, smoked for 15 years, and had no past history of diabetes mellitus, hypertension, TB, or HIV. An abdominal ultrasound and CT scan at admission showed pancreatitis with a splenic abscess. After five days of admission, the patient's vitals deteriorated, and he had severe abdominal pain. CT scan suggested a splenic abscess rupture with hemoperitoneum. An emergency exploratory laparotomy was performed, and a splenectomy was done due to the splenic abscess rupture. A cartridge-based nucleic acid amplification test from splenic intracapsular fluid detected a trace Mycobacterium tuberculosis complex. The patient was discharged after starting first-line antitubercular treatment for six months. After three months of follow-up, the patient was doing well with no complaints.

show abstract

“…The chemical groups of graphene oxide have been found to be a feasible and effective means of improving the dispersion of graphene. In addition, functional side groups bound to the surface of graphene oxide are there to improve the interfacial interaction between graphene oxide and the matrix, similarly to that observed for functionalised carbon nanotube-based nanocomposites [15]. Therefore, by combining the remarkable mechanical properties of graphene oxide sheets with green synthesised nanoparticles, they offer promising nanoscale fillers for the next generation of nanocomposite materials [16].…”

Section: Introductionmentioning

confidence: 86%

Green Method Synthesised Graphene-Silver Electrochemical Nanobiosensors for Ethambutol and Pyrazinamide

et al. 2020

View full text Add to dashboard Cite

A novel nanobiosensor was constructed with graphene oxide (GO) sheets coupled to pear extract-based green-synthesised silver nanoparticles (Ag-NPs) to which cytochrome P450-2D6 (CYP2D6) enzyme was attached. The biosensor was applied in the electrochemical detection of the tuberculosis (TB) treatment drugs, ethambutol (EMB) and pyrazinamide (PZA). The surface morphology of the green-synthesised nanocomposites was studied by performing High-Resolution Transmission Electron Microscopy (HR-TEM) and High-Resolution Scanning Electron Microscopy (HR-SEM). Fourier Transform Infrared Spectroscopy (FTIR) and Raman Spectroscopy were used for structural analysis, while Ultraviolet Visible (UV-Vis) Spectroscopy was used in the optical characterisation of the nanocomposite material. Electrochemical studies on glassy carbon electrode (GCE), which were done by Cyclic Voltammetry (CV), showed that the GO|Ag-NPs||GCE electrode was highly conductive, and thereby indicating its suitability as a platform for nanobiosensor development. The non-toxic and low-cost green GO|Ag-NPs|CYP2D6||GCE nanobiosensor was used to determine EMB and PZA. The very low limit of detection (LOD) values of the biosensor for EMB (0.2962 × 10−2 nM, S/N = 3) and PZA (0.897 × 10−2 nM, S/N = 3) demonstrate that the green nanobiosensor is more sensitive than other biosensors reported for EMB and PZA.

show abstract

Isolated primary tuberculosis of spleen—A rare entity in the immuno-competent patient

Cited by 10 publications

References 8 publications

First Report of an Association Between Crohn’s Disease and Isolated Splenic Tuberculosis in Pediatric Population

First Report of an Association Between Crohn’s Disease and Isolated Splenic Tuberculosis in Pediatric Population

A Case of Isolated Splenic Tuberculosis Presenting as a Splenic Abscess Complicated by Rupture Leading to Splenectomy in an Immunocompetent Male

Green Method Synthesised Graphene-Silver Electrochemical Nanobiosensors for Ethambutol and Pyrazinamide

Contact Info

Product

Resources

About