Isolated perfused lung extraction and HPLC–ESI–MSn analysis for predicting bioactive components of Saposhnikoviae Radix

Saposhnikoviae divaricata : a phytochemical, pharmacological, and pharmacokinetic review

“…Phytochemistry papers were further screened according to the selection criteria and 21 papers were excluded due to non-PSVN (n = 17), different reporting standards of measure standard (n = 2), standard procedures of reporting chromatographic profile not followed (n = 1) and study on soil element of SD (n = 1). As a result, 4 SD phytochemical studies only [4][5][6][7] adhered to the scientific rigors that ensure the integrity in validation and robustness in quantitative outcomes. Among 9 phytochemistry papers with in vitro studies [8][9][10][11][12][13][14][15][16] , 5 [11,[13][14][15][16] were selected based on their relevance, but the phytochemistry component did not adhere to the selection criteria.…”

Saposhnikovia divaricata—An Ethnopharmacological, Phytochemical and Pharmacological Review

“…Phytochemical studies have revealed that there are approximately 100 compounds with different structural patterns isolated from S. divaricata, including chromones, coumarins, acid esters, polyacetylenes, volatile oils, polysaccharides, and inorganic elements (1,4,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) as shown in Appendixes 3-9.…”

“…They have extremely diverse structures, which are divided into simple coumarins, pyranocoumarins, furanocoumarins, and other coumarins. (1,21,22) At present, a total of 35 coumarins, primarily furanocoumarins and pyranocoumarins, have been identified from S. divaricata (Appendixes 4 and 5). Among them, the 17 furanocoumarins isolated include bergapten (18), byakangelicin (19), deltoin (20), imperatorin (21), isoimperatorin (22), isobergapten (23), marmesin (24), methoxy-8-(3-hydroxymethylbut-2-enyloxy)-psoralen (25), nodakenetin (26), oxypeucedanin hydrate (27), phellopterin (28), psoralen (29), sapodivarin (30), xanthotoxin (31), 5-hydroxy-8-methoxypsoralen (32), nodakenin (33), and xanthoarnol (34).…”

Macrophage biospecific extraction and HPLC–ESI-MSn analysis for screening immunological active components in Smilacis Glabrae Rhizoma

“…Therefore, the interaction of drugs with cell membranes, cells or organ has been successfully used as a basis for hypothesis of bioactive components in TCM [5][6][7]. Meanwhile, HPLC-ESI-MS n , a powerful technique for identification of unknown molecules, has been more and more applied to the modern pharmaceutical analysis of TCM [8,9].…”