Isolated ovarian vein thrombosis in COVID-19 infection

Abstract

COVID-19 (coronavirus disease-19) is associated with an increased risk for thrombosis due to endothelial dysfunction and hyperactivation of the immune system induced by the virus. Most cases of venous thromboembolism associated with COVID-19 are either pulmonary emboli or deep vein thromboses. Ovarian vein thrombosis is a rare condition most commonly seen in the postpartum period. This report describes a case of COVID-19-associated ovarian vein thrombosis in a nonpregnant woman with no evidence of underlying inherited coagulopathy.

Ovarian Vein Thrombosis: A Sequela of COVID-Associated Coagulopathy

“…Symptomatic postpartum OVT occurs in 0.01-0.05% of deliveries, especially in C-sections [17]. In this review, no significant obstetric history was found in the majority of the cases (77.77%) [6,11,13,14,[18][19][20].…”

“…Symptomatic postpartum OVT occurs in 0.01-0.05% of deliveries, especially in C-sections [ 17 ]. In this review, no significant obstetric history was found in the majority of the cases (77.77%) [ 6 , 11 , 13 , 14 , 18 - 20 ]. Pregnancy and post-partum were only associated with OVT in 22.22% of cases [ 14 , 21 ].…”

“…Our review corroborates a similar finding. A total of 66.66% of patients presented within the first two weeks after a COVID-positive test [11,13,[18][19][20][21]. The remaining 33.33% of patients took three to eight weeks for presentation [6,14].…”

“…Fever in septic pelvic thrombophlebitis is spiking and associated with chills [12]. Abdominal pain is reported in all cases of OVT post-COVID [6,11,13,14,[18][19][20][21]. Clinical profile of the patients can be seen in Table 2.…”

“…The only widely available treatment in CAC is a prophylactic dose of low molecular weight heparin like enoxaparin, which should be considered in all patients (including non-critically ill) who require hospital admission for COVID-19 infection [13]. While there is no particular regimen for treating VTE secondary to COVID-19 infection, the literature backs the use of apixaban or enoxaparin/acenocoumarol [6,11,13,14,[18][19][20][21]. Diagnostic methods and management of the patients are stated in Table 4.…”