Ovarian Vein Thrombosis: A Sequela of COVID-Associated Coagulopathy

Patel, Shlok V; Shah, Stuti; Patel, Rina; Bavishi, Shriya; Pethani, Yashvi; Shah, Kalp

doi:10.7759/cureus.36437

Cited by 2 publications

(1 citation statement)

References 28 publications

(95 reference statements)

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“…Coronavirus disease 2019 (COVID-19) is well known to cause a general hypercoagulable state and has been associated with many cases of stroke, myocardial infarction, and deep venous thrombosis. OVT was also reported with COVID-19 infection in a few case reports [7].…”

Section: Figure 2: Illustration Demonstrates Thrombus Propagation Fro...mentioning

confidence: 85%

Imaging Findings of Ovarian Vein Thrombosis

El-Diasty,

Noorelahi

2023

Cureus

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Ovarian vein thrombosis (OVT) is an uncommon condition that occurs mainly in the peripartum period. Hyper-coagulable conditions have been reported to cause OVT outside the peripartum period. The clinical presentation is usually nonspecific pain, but it can be asymptomatic in patients with underlying malignancy. Imaging plays an important role in diagnosis. Ultrasound is the initial imaging modality, but it is operatordependent and has limited sensitivity. Computed tomography (CT) is the most commonly used modality for diagnosis. CT can show the luminal filling defect within the thrombosed vein and assess the extension of the thrombosis. MRI can show the thrombosed vein as a filling defect on post-contrast images; also, diffusionweighted images may help in the diagnosis. Complications include extension into the inferior vena cava or renal veins. Pulmonary embolism is the most serious complication. Treatment includes anticoagulation plus antibiotics. Early diagnosis is essential to prevent complications.

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Section: Figure 2: Illustration Demonstrates Thrombus Propagation Fro...mentioning

confidence: 85%

Imaging Findings of Ovarian Vein Thrombosis

El-Diasty,

Noorelahi

2023

Cureus

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The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management

Becker,

Tantry,

Khan

et al. 2024

J Thromb Thrombolysis

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A heightened risk for thrombosis is a hallmark of COVID-19. Expansive clinical experience and medical literature have characterized small (micro) and large (macro) vessel involvement of the venous and arterial circulatory systems. Most events occur in patients with serious or critical illness in the hyperacute (first 1–2 weeks) or acute phases (2–4 weeks) of SARS-CoV-2 infection. However, thrombosis involving the venous, arterial, and microcirculatory systems has been reported in the subacute (4–8 weeks), convalescent (> 8–12 weeks) and chronic phases (> 12 weeks) among patients with mild-to-moderate illness. The purpose of the current focused review is to highlight the distinguishing clinical features, pathological components, and potential mechanisms of venous, arterial, and microvascular thrombosis in patients with COVID-19. The overarching objective is to better understand the proclivity for thrombosis, laying a solid foundation for screening and surveillance modalities, preventive strategies, and optimal patient management. Graphical abstract Thrombosis involving the arterial, venous, and microvascular circulatory systems is a hallmark of COVID-19 contributing to organ injury, morbidity, and mortality. The COVID-19 thrombus has unique and distinct characteristics. Among them are a highly inflammatory signature on a foundation of endothelial cell inflammation and neutrophil extracellular traps (NETs). While the SARS-CoV-2 virus and resulting host immunoinflammatory response to this pathogen provide an underpinning for vascular events, the virus spike protein is necessary and likely sufficient for acute, subacute, and potentially in a latent form harbored in adipocytes, vascular endothelial cells, and circulating monocytes potentially contributing to post-infectious atherothrombotic phenotypes.

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Ovarian Vein Thrombosis: A Sequela of COVID-Associated Coagulopathy

Cited by 2 publications

References 28 publications

Imaging Findings of Ovarian Vein Thrombosis

Imaging Findings of Ovarian Vein Thrombosis

The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management

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