Isolated intracranial myeloid sarcoma

Hodges, Georgina; Lai, Hock Choong; Irving, Ian; Macloud, Meredith; Korah, Ipeson; Ramuz, Olivier; Morris, Edward S.

doi:10.1097/pat.0b013e3283583413

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…MRI has high diagnostic value in intracranial GS. Previous cases reported that GS shows hyperintense signal on T1WI and hypointense to hyperintense signal on T2WI, DWI and ADC can show restricted diffusion 7,8 . However, This case showed hypointense signal on DWI and ADC and have no restricted diffusion.…”

Section: Discussionmentioning

confidence: 91%

Intracranial granulocytic sarcoma mimicking a hematoma in a child with acute myelogenous leukemia

Liu,

Zhu,

Yang

et al. 2024

Preprint

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Granulocytic sarcoma (GS) is a soft mass formed by immature myeloid cells invading extramedullary tissues and organs, which is common in myeloid leukemia. In this case, a two years and four months girl diagnosed with acute myeloid leukemia showed intracranial lesion with right occipital bone involvement on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Follow-up CT showed that the mass had disappeared after chemotherapy. As intracranial GS is difficult to diagnose accurately, early detection and treatment is vital for good prognosis. GS should be part of differential diagnosis when patients with acute myelogenous leukemia showed intracranial soft mass.

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Section: Discussionmentioning

confidence: 91%

Intracranial granulocytic sarcoma mimicking a hematoma in a child with acute myelogenous leukemia

Liu,

Zhu,

Yang

et al. 2024

Preprint

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“…On MRI, lesions are usually hypointense to isointense on T1- and T2-weighted images 5. When presenting as dural-based mass lesions, radiological differential diagnosis includes haematoma, brain abscess, meningioma, metastatic neuroblastoma and lymphoma 9 10.…”

Section: Discussionmentioning

confidence: 99%

“…In children with newly diagnosed AML, extramedullary involvement is most common in the skin with orbital involvement being the second most common site 4. MS involving the central nervous system (CNS) are rare, accounting for approximately 3% of all cases 5. When CNS disease occurs, patients can display a heterogeneous clinical picture ranging from minor headaches and paraesthesia to pronounced stupor and hemiplegia 6.…”

Section: Introductionmentioning

confidence: 99%

Acute myeloid leukaemia masquerading as a primary CNS tumour

Cuglievan¹,

Menegaz

Garcés

et al. 2017

BMJ Case Reports

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In children with newly diagnosed acute myeloid leukaemia (AML), myeloid sarcomas (MS) of the central nervous system (CNS) are rare. Since MS involving the CNS are potentially curable, timely recognition is paramount. Establishing a diagnosis may be problematic as they can easily mimic primary CNS neoplasms. We report the case of a 5-year-old boy with AML with t(8;21)(q22;q22) rearrangement who presented with a massive intracranial MS and rapid clinical deterioration suggestive of a meningioma or a primitive neuroectodermal tumour. The peripheral smear showed blasts with Auer rods. Urgent chemotherapy was started for AML with presumptive CNS MS. The mass resolved with chemotherapy, and treatment was consolidated with radiotherapy. Although exceedingly rare, this case highlights the potential for MS to present similarly to a primary CNS tumour. MS should be part of the differential diagnosis as part of a CNS mass, particularly if the complete blood count is abnormal.

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