Isolated Gut Relapse Presenting as Chronic Diarrhea During Maintenance Therapy for Acute Lymphoblastic Leukemia

Bhatti, Anuj; Bansal, Deepak; Vashishta, Rakesh Kumar; Lal, Sadhna

doi:10.1097/mph.0b013e3181e0159a

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Rare sites of EMR in the pediatric population include the sciatic nerve, with at least one case involving the musculature surrounding the nerve [ 23 , 24 ]. Researchers have also found that isolated symptoms such as chronic diarrhea and weight loss signify isolated relapse of ALL in the gut [ 25 ]. A complicating factor in gut relapse of ALL following a stem cell transplant is distinguishing GVHD from the relapse [ 26 , 27 ].…”

Section: Emr Of Allmentioning

confidence: 99%

Cardiac Relapse of Acute Lymphoblastic Leukemia Following Hematopoietic Stem Cell Transplantation: A Case Report and Review of Literature

Sheikh

Ragoonanan

Franklin

et al. 2021

Cancers

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Isolated extramedullary relapse of acute lymphoblastic leukemia (ALL) occurs in soft tissues and various organs outside the testis and central nervous system. Treatments such as hematopoietic stem cell transplantation and more novel modalities such as immunotherapy have eradicated ALL at extramedullary sites. In some instances, survival times for relapsed ALL at these sites are longer than those for relapsed disease involving only the bone marrow. Isolated relapse of ALL in the myocardium is rare, especially in children, making diagnosis and treatment of it difficult. More recent treatment options such as chimeric antigen receptor T-cell therapy carry a high risk of cytokine release syndrome and associated risk of worsening cardiac function. Herein we present the case of an 11-year-old boy who presented with relapsed symptomatic B-cell ALL in the myocardium following allogeneic hematopoietic stem cell transplantation. This is an unusual presentation of relapsed ALL and this case demonstrates the associated challenges in its diagnosis and treatment. The case report is followed by a literature review of the advances in treatment of pediatric leukemia and their application to extramedullary relapse of this disease in particular.

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Section: Emr Of Allmentioning

confidence: 99%

Cardiac Relapse of Acute Lymphoblastic Leukemia Following Hematopoietic Stem Cell Transplantation: A Case Report and Review of Literature

Sheikh

Ragoonanan

Franklin

et al. 2021

Cancers

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Cryptosporidium gastroenteritis in Egyptian children with acute lymphoblastic leukemia: magnitude of the problem

et al. 2011

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Unusual Sites of Relapse in Pre-B Acute Lymphoblastic Leukemia

Jain¹,

Trehan²,

Singh

et al. 2014

Journal of Pediatric Hematology/Oncology

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Relapses of acute lymphoblastic leukemia (ALL) in unusual sites can be challenging to diagnose. We present unusual relapses occurring in children with ALL treated in a single institution over a 22-year period. Of 172 relapses, 9 (5.2%) were at unusual sites (nonmarrow, testes, central nervous system). The most common site of relapse was ocular (66%). The median symptom-to-diagnosis interval was 20 days. Two of 9 children attained second remission. A possibility of relapse should be considered when evaluating unusual symptoms in a child with underlying ALL.

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Isolated Gut Relapse Presenting as Chronic Diarrhea During Maintenance Therapy for Acute Lymphoblastic Leukemia

Cited by 3 publications

References 7 publications

Cardiac Relapse of Acute Lymphoblastic Leukemia Following Hematopoietic Stem Cell Transplantation: A Case Report and Review of Literature

Cardiac Relapse of Acute Lymphoblastic Leukemia Following Hematopoietic Stem Cell Transplantation: A Case Report and Review of Literature

Cryptosporidium gastroenteritis in Egyptian children with acute lymphoblastic leukemia: magnitude of the problem

Unusual Sites of Relapse in Pre-B Acute Lymphoblastic Leukemia

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