Cryptosporidium infection should be considered in children with ALL presenting with prolonged or severe watery diarrhea during chemotherapy, especially those treated with methotrexate and 6-mercaptopurine. Since Cryptosporidium is not routinely tested for in stool examination, a MZN stain is recommended.
This research aims to study the hot water recirculation at the power plants intakes due to the discharge from the plant cooling system into a low flow receiving water body. To achieve this objective, a 3Dnumerical model was employed to study the effect of the main parameters in this phenomena such as the plant intake length (L), the distance between the plant intake and outfall (S), the water depth under the intake skimmer wall (h) and the water depth just upstream the intake (D) on the recirculation of hot water to the plant intake. Eight scenarios were tested and two mathematical formulas accounting for the effect of these parameters on the hot water concentration at the plant intake were deduced. Physical model tests were carried out to verify the accuracy of the two deduced formulas. The study results indicated that the measured thermal concentrations in the physical model tests coincide with those calculated by the two above-mentioned mathematical formulas.
This study aimed to evaluate the antimicrobial, antioxidant, and cytotoxic potentials of crude extract of marine actinomycetes spp. isolated from the Red Sea water at Hurghada, Egypt. Out of 80 actinomycetes isolates, the isolate Actinomyces sp. AW6 was selected based on its antioxidant (IC50 about 5.24 µg/ml which scavenged 91% of formed DPPH free radicals) and antimicrobial potential against E. coli, S. aureus, B. subtilis, and P. aeruginosa, A. niger, and C. albicans. The strain was identified based on phenotypic and genotypic analysis and deposited in the GenBank with accession number OK090864. 1. Cultivation of the selected strain on rice, chromatographic purification, and structural elucidation led to the isolation of two compounds C1: umbelliferone and C2: 1-methoxy-3-methyl-8-hydroxy-anthraquinone. The antimicrobial activity of the obtained compounds showed that C1 and C2 have low antibacterial activity toward S. aureus and E. coli with no pronounced activity toward P. aeruginosa, C. albicans, and A. niger. Additionally, the antioxidant activity of C1 and C2 revealed that C2 has a good antioxidant activity, with DPPH scavenging activity reaching (55.25%), followed by C1 (30.20%). Moreover, both compounds displayed anti-Gyr-B enzyme activity with IC50 value of (3.79 ± 0.21 µM) for C1, and (IC50 = 13 ± 0.71µM) for C2. The ADME-related physicochemical properties of the obtained compound were predicted using SwissADME web tools and the ProToxii webserver was used to estimate in silico toxicity.
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