Isolated gastric crystal-storing histiocytosis: a rare marker of occult lymphoproliferative disorders

Lambda-Restricted Crystal-Storing Histiocytosis of Stomach: A Case Report and Review of Literature

“…The clinicopathological features of the reported cases have been presented in Table 1 [1][2][3][4][5][6][7][8][9]. CSH localized to the stomach was seen in 85% cases (11/13 cases).…”

“…The disease usually involves the lung, lymph node, bone marrow, thymus and spleen with rare involvement of the gastrointestinal tract. Involvement of the stomach is rarely reported in the English literature [1][2][3][4][5][6][7][8][9]. We report the case of lambda-restricted gastric CSH, which later uncovered an underlying diffuse large B-cell lymphoma (DLBCL) involving multiple lymph nodes and bone marrow.…”

Rare Gastric Lesions Associated with Helicobacter pylori Infection: A Histopathological Review

“…Although many cases of CSH are systemic, organ-confined CSH has been described in the lung, lymph node, kidney, thyroid, thymus, parotid gland, and cornea [43,65-71]. CSH is extremely rare in the stomach, and only eight cases of gastric CSH have been described to date in the English literature (Table 2) [10,11,43,71,72]. Among these, H. pylori infection was identified in four patients (50%) who did not exhibit concomitant gastric lesions (except for H. pylori gastritis) or a systemic disorder that might have caused monoclonal gammopathy [10,11].…”

“…Among these, H. pylori infection was identified in four patients (50%) who did not exhibit concomitant gastric lesions (except for H. pylori gastritis) or a systemic disorder that might have caused monoclonal gammopathy [10,11]. In the other four patients, there was no mention of H. pylori infection [43,71,72], and two of them were subsequently diagnosed with thymic lymphoma [43] and plasma cell myeloma [71], respectively. Therefore, although overproduction of immunoglobulin due to H. pylori infection could be a plausible cause of isolated gastric CSH, clinical workup is needed to exclude the possibility that it is a manifestation of underlying lymphoma or plasma cell myeloma.…”

“…Therefore, although overproduction of immunoglobulin due to H. pylori infection could be a plausible cause of isolated gastric CSH, clinical workup is needed to exclude the possibility that it is a manifestation of underlying lymphoma or plasma cell myeloma. Light chain restriction was detected in five of seven cases (kappa restriction in two case and lambda restriction in three cases) [10,71,72], all of which except one had no associated B-cell/plasmacytic neoplasms. Thus, light chain restriction detected in isolated gastric CSH does not necessarily mean that it is associated with B-cell or plasmacytic neoplasm.…”