2015
DOI: 10.1093/cercor/bhv313
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Isolated Focal Dystonia as a Disorder of Large-Scale Functional Networks

Abstract: Isolated focal dystonias are a group of disorders with diverse symptomatology but unknown pathophysiology. Although recent neuroimaging studies demonstrated regional changes in brain connectivity, it remains unclear whether focal dystonia may be considered a disorder of abnormal networks. We examined topology as well as the global and local features of large-scale functional brain networks across different forms of isolated focal dystonia, including patients with task-specific (TSD) and nontask-specific (NTSD)… Show more

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Cited by 75 publications
(135 citation statements)
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“…Stratifying patients on the basis of the affected body region further showed that the pathophysiological complexity of each TSFD phenotype may be accounted for by different, albeit spatially neighboring, functional and structural aberrations of the parietal cortex. These areas have been previously shown to be altered in focal dystonias, linked to their polygenic risk, and considered as one of the objective diagnostic biomarkers of this disorder …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Stratifying patients on the basis of the affected body region further showed that the pathophysiological complexity of each TSFD phenotype may be accounted for by different, albeit spatially neighboring, functional and structural aberrations of the parietal cortex. These areas have been previously shown to be altered in focal dystonias, linked to their polygenic risk, and considered as one of the objective diagnostic biomarkers of this disorder …”
Section: Discussionmentioning
confidence: 99%
“…Recent neuroimaging studies have shown that, compared to other focal dystonias (e.g., blepharospasm and cervical dystonia), TSFD patients present not only with abnormalities in the basal ganglia, cerebellum, and primary sensorimotor cortex, but also in higher‐order motor and associative cortical regions . Overall greater involvement of cortical alterations in TSFD is thought to reflect impairments of highly learned, complex sequences of voluntary motor actions, whereas other dystonias are characterized by loss of control of more stereotyped movements (e.g., eye blinking, neck posture).…”
mentioning
confidence: 99%
“…This concept has been recently experimentally substantiated in a study that used a graph theoretical approach to probe the organization of large-scale functional networks across different forms of focal dystonia. Compared to healthy subjects, patients showed altered network architecture, which was characterized by an abnormal breakdown of the basal gangliathalamo-cerebellar community, a loss of pivotal regions of information transfer (hubs) in the premotor cortex, and a pronounced decline in sensorimotor and inferior parietal cortical connectivity (Battistella, Termsarasab, Ramdhani, Fuertinger, & Simonyan, 2017) (Fig. 5A).…”
Section: Functional Neuroimaging Of Dystoniamentioning
confidence: 99%
“…6/17, area 6/17; 7A/7P, subdivisions of area 7; CbI-I/IV/Cbl-V/Cbl-VI, cerebellar lobules I/IV/V/VI; Cu/PCu, cuneus/precuneus; FG, fusiform gyrus; Ig1, part Ig1 of the insula; LG, lingual gyrus; MCC/PCC, middle/posterior cingulate cortex; SOG, superior orbital gyrus; Tp/Tpf/Ts/Tt, parietal/prefrontal/somatosensory/temporal subdivisions of the thalamus; hOC4v, ventral part of area hOC4; L, left; R, right. Panel (A): Adapted from Battistella, G., Termsarasab, P., Ramdhani, R. A., Fuertinger, S., & Simonyan, K. (2017). Isolated focal dystonia as a disorder of large-scale functional networks .…”
Section: Figmentioning
confidence: 99%
“…Understanding how striatal pathology affects network-level FC in preclinical models is important for dissecting pathophysiology and providing readouts for disease modifying interventions. Further, understanding network-level connectivity in a translational model of generalized dystonia is opportune because motor impairment in human subjects with focal dystonia points to disturbances in FC (Battistella et al, 2015; 2016). …”
Section: Introduction1mentioning
confidence: 99%