2019
DOI: 10.1002/mds.27649
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Functional and structural neural bases of task specificity in isolated focal dystonia

Abstract: Background Task‐specific focal dystonias selectively affect movements during the production of highly learned and complex motor behaviors. Manifestation of some task‐specific focal dystonias, such as musician's dystonia, has been associated with excessive practice and overuse, whereas the etiology of others remains largely unknown. Objectives In this study, we aimed to examine the neural correlates of task‐specific dystonias in order to determine their disorder‐specific pathophysiological traits. Methods Using… Show more

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Cited by 39 publications
(74 citation statements)
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References 63 publications
(153 reference statements)
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“…Abnormalities in resting‐state function activity and connectivity in patients with musician's and nonmusician's dystonia were reported in our previous articles . In this study, voxelwise correlations between TDT z scores and resting‐state brain activity were examined within each group.…”
Section: Resultsmentioning
confidence: 82%
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“…Abnormalities in resting‐state function activity and connectivity in patients with musician's and nonmusician's dystonia were reported in our previous articles . In this study, voxelwise correlations between TDT z scores and resting‐state brain activity were examined within each group.…”
Section: Resultsmentioning
confidence: 82%
“…Taking into account these findings in healthy individuals, the correlations between temporal discrimination and inferior parietal activity as well as any other brain regions present in healthy individuals were lost in nonmusician's dystonia, likely leading to abnormally increased TDT in these patients. Abnormal structural organization, functional activity, and connectivity of the inferior parietal cortex, including the angular gyrus, have been increasingly implicated in the pathophysiology of focal hand dystonia and laryngeal dystonia . Vulnerable parietal–premotor functional connectivity has been associated with the polygenic risk of dystonia, whereas maladaptive plasticity of the inferior parietal cortex has been related to the loss of inhibition as a result of reduced gamma‐aminobutyric acid (GABA)‐ergic function .…”
Section: Discussionmentioning
confidence: 99%
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“…Specifically, the biomarker components that were automatically learned by DystoniaNet as most informative for discriminating the disorder have been previously demonstrated to be aberrant in patients with dystonia. While gray matter changes appear to be more relevant to dystonia form-specific aberrations ( 29 32 ), white matter alterations across different forms of dystonia emerge as a more common feature of this disorder. Structural abnormalities in the corpus callosum were previously reported within the dystonia spectrum, including laryngeal dystonia, cervical dystonia, and blepharospasm, as well as focal hand dystonia, musician’s dystonia, X-linked dystonia-parkinsonism, and poststroke lingual dystonia (e.g., refs.…”
Section: Discussionmentioning
confidence: 99%
“…The anterior part of inferior parietal lobule (aIPL) has inhibitory control over the ipsilateral primary motor cortex (M1) [8] and is also involved in precision grasp [9]. Moreover, FHD patients exhibiting reduced mSI [3,10] also have aberrant parietal-premotor-motor functional connectivity [11,12]. Hence, we speculated that this inhibitory parietomotor network would influence mSI.…”
Section: Introductionmentioning
confidence: 99%