Isolated Complete Cleft

Powar, Rajesh; Prabhu, Avinash; Prabhu, Mahesh

doi:10.1016/j.athoracsur.2012.02.086

Cited by 6 publications

(11 citation statements)

References 7 publications

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“…Syndromic associations of congenital sternal anomalies include trisomy 7, 9, 12p or 18, pentalogy of cantrell, moebius syndrome, turner syndrome and noonan syndrome. 2…”

Section: Discussionmentioning

confidence: 99%

“…If diagnosed early, these isolated anomalies are potentially correctable and have a better prognosis than if they are associated with other deformities. 2,4 In such isolated cases however, the etiology is not well understood. Various possible causes have been proposed based on animal models such as alcohol exposure, riboflavin and methyl cobalamin deficiency as well as genetic factors such as HOX4 gene disruption.…”

Section: A B C D E F Figure 4: Mri Thorax Of the Patient T2w Axial Smentioning

confidence: 99%

“…Congenital sternal anomalies such as sternal agenesis, sternal hypoplasia and cleft sternum are usually seen as part of syndromes and have been very rarely reported in isolation. 2 Isolated sternal anomalies may also cause kyphoscoliosis secondary to the bony deformity although this has not previously been reported in literature. Here authors report an unusual case of kyphoscoliosis secondary to isolated sternal hypoplasia in an adolescent male patient.…”

Section: Introductionmentioning

confidence: 97%

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Isolated sternal hypoplasia: a rare cause of kyphoscoliosis

et al. 2019

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In most cases, kyphoscoliosis is idiopathic. However, this is a diagnosis of exclusion and can be made only if no cause can be identified. Kyphoscoliosis can occur due to various causes. Isolated sternal anomalies may also cause kyphoscoliosis secondary to the bony deformity though this has not previously been reported in literature. We have reported a case of kyphoscoliosis secondary to isolated sternal hypoplasia with complete absence of bony and cartilaginous elements of the body and xiphoid process of the sternum without any associated deformities of mediastinal structures, lung parenchyma or soft tissues in a young male patient. Careful evaluation of patients with kyphoscoliosis can ensure timely diagnosis of unusual and potentially treatable causes for the same such as sternal anomalies. Addition of lateral chest radiographs to the imaging protocol for evaluation of kyphoscoliosis can play a major role in timely diagnosis of such cases.

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“…Syndromic associations of congenital sternal anomalies include trisomy 7, 9, 12p or 18, pentalogy of cantrell, moebius syndrome, turner syndrome and noonan syndrome. 2…”

Section: Discussionmentioning

confidence: 99%

Section: A B C D E F Figure 4: Mri Thorax Of the Patient T2w Axial Smentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Isolated sternal hypoplasia: a rare cause of kyphoscoliosis

et al. 2019

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“…Although pectus excavatum, pectus carinatum, and cleft sternum can present as isolated deformity (less than 30 cases of isolated cleft sternum are reported in literature) [2–6], in most cases they are associated with heart and inner organs anomalies and described as symptoms of syndromes like Marfan syndrome, Noonan syndrome, Poland anomaly, and Cantrell pentalogy [1–7]. …”

Section: Discussionmentioning

confidence: 99%

“…Many factors have been associated with murine models, like alcohol, riboflavin and methylcobalamin deficiency, and HOX4 gene disruption, but no significant associations have been reported in humans [2–7]. …”

Section: Discussionmentioning

confidence: 99%

Isolated Asymptomatic Short Sternum in a Healthy Young Girl

Turturro

Calderaro

Montanaro

et al. 2014

Case Reports in Radiology

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Congenital sternal defects are rare deformities frequently associated with other anomalies of the chest wall and other organ systems. Although pectus excavatum, pectus carinatum, and cleft sternum can present as isolated deformity, in most cases they are associated with heart and inner organs anomalies and described as symptoms of syndromes like Marfan syndrome, Noonan syndrome, Poland anomaly, and Cantrell pentalogy. In contrast, the etiology of an isolated defect is not well understood. We observed a short sternum (dysmorphic manubrium, hypoplastic body, and complete absence of the xiphoid process) in a completely asymptomatic 13-year-old woman. A comprehensive instrumental exams panel was performed to exclude associated anomalies of the heart and of the other organ systems. The patient was completely asymptomatic and she did not need any medical or surgical treatment. To our knowledge, this is the first case of isolated short sternum reported in literature.

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