Isolated bowel segment created by omentoenteropexy: histologic findings

Günel, Erdoǵan; Tavll, L.; Çağlayan, Fatma; Gündoğan, Ahmet Hamdi

doi:10.1007/bf01076940

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…The procedure is simple and can be used without major risks for the animal. It has been documented that the omentum, as well as other fatty tissues, has intense angiogenic activity (1,3,4,10) . In total, 38 rats were used in this experiment.…”

Section: Discussionmentioning

confidence: 99%

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A morphometric study of the intestinal mucosa of rats submitted to omentoenteropexy

Fernandez

Pollachi

Cordeiro

et al. 2011

Arq. Gastroenterol.

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-Context -The omentoenteropexy technique was developed as an alternative method for intestinal neovascularization, due to the angiogenic properties of factors from the omentum. Objectives -This study investigated changes in intestinal villi heights and crypts depths due to surgical techniques: seromiotomy with and without omentoenteropexy. Method -Thirty rats were operated on, after being divided into three groups, namely GI, GII and GIII with 10 rats each. In the GI rats were submitted to omentoenteropexy; rats in GII were submitted only to a seromiotomy, and in the GIII only laparotomy. Sixty days after the first surgery, the animals were sacrificed and a segment of intestine was removed for histology using Masson's trichrome technique and morphometric study of intestinal mucosa.Results -The histological findings showed that seromiotomy with or without omentoenteropexy increased the length of intestinal villi when compared with GIII (only laparotomy) (analysis of variance: P = 0.0068; GI 38.88 ± 4.17; GII 39.41± 6.33; GIII 31.85 ± 5.56; GI = GII P>0.05; GII>GIII P<0.05; GI>GIII P<0.001). Conclusion -No differences were demonstrated in relation to crypt depths between the groups (P = 0.60). Ongoing studies are being set forth by our group to add more data on the role of omentopexy as a tool to promote neovascularization and intestinal mucosal growth.

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Section: Discussionmentioning

confidence: 99%

“…The lipid material obtained from the omentum contains a potent angiogenic factor extracted by a mixture of chloroform and metanol (1,2) . It is possible to create an isolated segment of bowel that is completely free of its mesentery, still with preserved viability and function (3,11) .…”

Section: Introductionmentioning

confidence: 99%

A morphometric study of the intestinal mucosa of rats submitted to omentoenteropexy

Fernandez

Pollachi

Cordeiro

et al. 2011

Arq. Gastroenterol.

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“…Beside intra-abdominal ischemic tissues, a great interest was focused on neovascularization of ischemic cerebral tissue with omentum [4,7,11,20]. Animal experiments have demonstrated that when omental vascularization occurs before MCA occlusion, it could replace the diminished blood flow and protect the brain [5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Omental Transposition Decreases Ischemic Brain Damage Examined in a New Ischemia Model

Vatansev

Üstün²,

Öğün³

et al. 2003

Eur Surg Res

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Purpose: The aim of this study was to determine whether omental transposition at the time of focal cerebral ischemia can decrease ischemic brain damage produced in dogs, in a new ischemia model, which had been described by us. Methods: In group 1 (n = 5), the left internal carotid artery and arterial circle of the brain (posterior communicating artery in humans) were occluded permanently. In group 2 (n = 5), additionally to this ischemia model, omental transposition was performed simultaneously. In the postoperative early period (first 24 h), single photon emission computed tomography (SPECT) and in the late period (72–96 h) SPECT and magnetic resonance imaging (MRI) of the brain were performed. Mann-Whitney U, paired t and Wilcoxon signed rank tests were used for statistical analyses, and p < 0.05 was considered significant. Results: The dogs had a neurological score (NS) of 3.6 ± 0.5 and 3.4 ±0.5 in groups 1 and 2, respectively, in the early period (p > 0.05). In the late period, the dogs had an NS of 4.4 ± 0.5 and 5.6 ± 0.5 in groups 1 and 2, respectively (p < 0.05). The NS of each group differed significantly between the early and late period (p < 0.05). Early SPECT imaging showed 50 ± 7.0% and 52 ± 8.4% hypoperfusion corresponding to the left middle cerebral artery territory in groups 1 and 2, respectively (p > 0.05). In the late period, the degree of hypoperfusion decreased to 34 ± 5.5% and 12 ± 4.8% in groups 1 and 2, respectively (p < 0.05). The degree of hypoperfusion in both groups changed significantly between the early and late period (p < 0.05). In T₁- and T₂-weighted MRI images, the volume of the lesion in group 1 was significantly greater than in group 2 (p < 0.001). Conclusion: In our new ischemia model, simultaneous omental transposition is helpful in reversing the neurologic deficit and cerebral ischemic damage.

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Regeneration of enteric ganglia in mechanically lengthened jejunum after restoration into intestinal continuity

Jabaji

Stark

Dunn

2013

Journal of Pediatric Surgery

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Isolated bowel segment created by omentoenteropexy: histologic findings

Cited by 6 publications

References 10 publications

A morphometric study of the intestinal mucosa of rats submitted to omentoenteropexy

A morphometric study of the intestinal mucosa of rats submitted to omentoenteropexy

Omental Transposition Decreases Ischemic Brain Damage Examined in a New Ischemia Model

Regeneration of enteric ganglia in mechanically lengthened jejunum after restoration into intestinal continuity

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