Isoflurane, and Not Halothane, Increases Mesenteric Blood Flow Supplying Esophageal Ileocoloplasty

Jacob, Laurent; Boudaoud, S.; Payen, Didier; Rabary, O; Sarfati, E.; Gossot, Dominique; Villiers, S.; Eurin, B

doi:10.1097/00000542-199104000-00013

Cited by 44 publications

(10 citation statements)

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“…However, isoflurane increased PVBF while maintaining a stable HABF, which led to the recorded increase in THBF. Cardiac output under volatile anesthesia was not measured in our study, but it would be expected to be moderately decreased in postoperative conditions (9). The major limitation of this study was the small number of patients.…”

Section: Resultsmentioning

confidence: 87%

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The Postoperative Effects of Halothane Versus Isoflurane on Hepatic Artery and Portal Vein Blood Flow in Humans

Gatecel

Losser

Payen

2003

Anesthesia & Analgesia

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Section: Resultsmentioning

confidence: 87%

“…Developments in Doppler technology and probe miniaturization have allowed us to monitor various vascular beds (8,9), including the liver after orthotopic transplant (10). With this technique, it is easy to monitor the two incoming flows to the liver and to assess their hemodynamic interactions during inhaled anesthesia.…”

mentioning

confidence: 99%

The Postoperative Effects of Halothane Versus Isoflurane on Hepatic Artery and Portal Vein Blood Flow in Humans

Gatecel

Losser

Payen

2003

Anesthesia & Analgesia

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“…The effects of the halogenated anesthetics on PCO 2 gap have not been compared or separately studied when gastrointestinal hypoxia is concerned, as occurs in hemorrhagic shock. In addition, the literature is scarce on the effects of halogenateds in mesenteric blood flow [24,25]. Isoflurane but not halothane increases mesenteric blow flow in humans [24].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the literature is scarce on the effects of halogenateds in mesenteric blood flow [24,25]. Isoflurane but not halothane increases mesenteric blow flow in humans [24]. However, halothane, in spite of markedly reduced mesenteric blood flow, does not impair gut mucosal oxygenation in pigs [25].…”

Section: Discussionmentioning

confidence: 99%

Gastric Mucosal Perfusion in Dogs: Effects of Halogenated Anesthetics and of Hemorrhage

Silva

Nascimento

Beier

et al. 2008

Journal of Investigative Surgery

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The gastrointestinal tract is one of the first organs affected by hypoperfusion during hemorrhagic shock. The hemodynamics and oxygen transport variables during hemorrhagic shock and resuscitation can be affected by the anesthetics used. In a model of pressure-guided hemorrhagic shock in dogs, we studied the effects of three halogenated anesthetics--halothane, sevoflurane, and isoflurane--at equipotent concentrations on gastric oxygenation. Thirty dogs were anesthetized with 1.0 minimum alveolar anesthetic concentration (MAC) of either halothane, sevoflurane, or isoflurane. A gastric tonometer was placed in the stomach to determine mucosal gastric CO(2) (PgCO(2)) and for the calculation of gastric-arterial PCO(2) gradient (PCO(2) gap). The dogs were splenectomized and hemorrhaged to hold mean arterial pressure at 40-50 mm Hg over 45 min and then resuscitated with the shed blood volume. Hemodynamics, systemic oxygenation, and PCO(2) gap were measured at baseline, after 45 min of hemorrhage, and at 15 and 60 min after blood resuscitation. Hemorrhage induced reductions of mean arterial pressure and cardiac index, while systemic oxygen extraction increased (p < .05), without significant differences among groups (p > .05). Halothane group showed significant lower PCO(2) gap values than the other groups (p < .05). After 60 min of shed blood replacement, all groups restored hemodynamics, systemic oxygenation, and PCO(2) gap to the prehemorrhage levels (p > .05), without significant differences among groups (p > .05). We conclude that halothane is superior to preserve the gastric mucosal perfusion in comparison to isoflurane and sevoflurane, in dogs submitted to pressure-guided hemorrhagic shock at equipotent doses of halogenated anesthetics.

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“…The importance of blood pressure for the secretory response is indicated by the positive linear correlation between the CT-induced fluid accumulation and the systolic blood pressure. An inhibitory effect of reduced blood pressure and impaired mesenteric blood flow (Jacob et al 1991;Loick et al 1991) on the secretory response in the halothane-treated pigs may be explained by reflexes elicited from volume receptors and baroreceptors. The influence of local capillary pressure on the secretory responses remains uncertain.…”

Section: Anaesthesiamentioning

confidence: 96%

Secretory response to cholera toxin in the porcine jejunum under different types of general anaesthesia

Maltbaek¹,

Ml²,

Berggreen³

et al. 1998

Experimental Physiology

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SUMMARYInvestigations of intestinal secretion are often performed under anaesthesia. This study evaluates the influence of anaesthetic agents on the intestinal secretion induced by cholera toxin (CT) in the pig. CT was instilled for 4 h in ligated jejunal loops under anaesthesia with halothane, saffan, a-chloralose, or propofol. Cardiovascular parameters, blood gas data, plasma cortisol levels, net fluid accumulation, intraluminal mediators (serotonin (5-HT), prostaglandin E2 (PGE2)) and electrolyte concentrations in the accumulated fluid were determined. The systolic blood pressure and heart rate was highest for saffan-anaesthetized pigs (blood pressure: saffan > a-chloralose > propofol = halothane; heart rate: saffan > a-chloralose = propofol = halothane), while blood gases and cortisol levels were within the same range. CT induced a dose-dependent fluid accumulation under all four anaesthetics. The fluid accumulation was significantly higher in pigs treated with saffan, a-chloralose and propofol than in halothane-treated pigs (saffan = a-chloralose > propofol > halothane). There was no significant difference in electrolyte concentrations in the accumulated fluid or in the luminal content of 5-HT and PGE2 between anaesthetics. The results demonstrate that anaesthetic agents profoundly influence the secretory response in the small intestine and indicate the importance of the choice of anaesthetic in this type of experiment.

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Isoflurane, and Not Halothane, Increases Mesenteric Blood Flow Supplying Esophageal Ileocoloplasty

Cited by 44 publications

References 0 publications

The Postoperative Effects of Halothane Versus Isoflurane on Hepatic Artery and Portal Vein Blood Flow in Humans

The Postoperative Effects of Halothane Versus Isoflurane on Hepatic Artery and Portal Vein Blood Flow in Humans

Gastric Mucosal Perfusion in Dogs: Effects of Halogenated Anesthetics and of Hemorrhage

Secretory response to cholera toxin in the porcine jejunum under different types of general anaesthesia

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