Isoflavone-rich soy protein prevents loss of hip lean mass but does not prevent the shift in regional fat distribution in perimenopausal women

Moeller, Laura E.; Peterson, Charles T.; Hanson, Kathy B.; Dent, Sarah B.; Lewis, David N.; King, Douglas S.; Alekel, D. Lee

doi:10.1097/01.gme.0000054763.94658.fd

Cited by 49 publications

(42 citation statements)

References 29 publications

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“…One explanation about this effect could be that skeletal muscle is an important site of estrogen receptors a (ERa) and -b (ERb) and that phytoestrogens are known to have estrogenic properties. In this sense, it has been demonstrated previously that soy protein supplementation has an effect on hip lean mass in perimenopausal women 40 g/day for 24weeks (Moeller et al, 2003); and on lean body mass in elite athletes, 1.5 g/kg/day for 8 weeks (Dragan et al, 1992). However, our study supports the fact that this effect was not solely because of an increase in dietary protein intake but likely to the beneficial effect of isoflavones on muscle tissue.…”

Section: Discussionsupporting

confidence: 80%

Six months of isoflavone supplement increases fat-free mass in obese–sarcopenic postmenopausal women: a randomized double-blind controlled trial

et al. 2007

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Objective: The aim of this study was to verify if six months of isoflavone supplementation could increase fat-free mass (FFM) and muscle mass index (MMI ¼ appendicular FFM/height 2 ) in obese-sarcopenic postmenopausal women. Design: Double-blind randomized study. Subject: Eighteen sarcopenic-obese women completed the study (12 on isoflavones and six on placebo). Body composition was measured by dual-energy X-ray absorptiometry. Subjects ingested 70 mg of isoflavones per day (44 mg of diadzein, 16 mg glycitein and 10 mg genestein) or a placebo for 24 weeks. Results: The isoflavone group increased significantly appendicular (P ¼ 0.034), leg (P ¼ 0.016) FFM and MMI (P ¼ 0.037), but not the placebo group. Conclusion: Six months of isoflavone supplementation increased FFM and MMI in obese-sarcopenic postmenopausal women.

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Section: Discussionsupporting

confidence: 80%

Six months of isoflavone supplement increases fat-free mass in obese–sarcopenic postmenopausal women: a randomized double-blind controlled trial

et al. 2007

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“…Moeller et al [15] reported lean tissue mass at the hip increased to a greater degree in the isoflavone-rich group in postmenopausal women. Aubertin-Leheudre et al [16] found isoflavones supplementation resulted in a small increase in fat-free mass.…”

Section: Discussionmentioning

confidence: 96%

“…Accumulating evidence suggests beneficial influence of soy isoflavones on metabolic and gynecologic conditions in women [12][13][14]. Recent studies in postmenopausal women, further, indicate protective effects of isoflavones on lean tissue [15] and fat-free mass [16].…”

Section: Introductionmentioning

confidence: 99%

Legumes and soy products consumption and functional disability in older women

Kim

Lee

2011

Maturitas

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“…To assess central adiposity, one evaluator sectioned each wholebody DXA scan into waist, hip, and thigh regions based on bone landmarks ( Fig. 2) (19,24) and these regions were analyzed using special software (Discovery, version 12.3:7 Hologic Inc., Waltham, MA, USA). The waist region included the first lumbar through the fourth lumbar vertebrae.…”

Section: Data Collectionmentioning

confidence: 99%

Centrally located body fat is related to appetitive hormones in healthy postmenopausal women.

Ritland¹,

Alekel²,

Matvienko³

et al. 2008

European Journal of Endocrinology

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Objective: Body composition and energy homeostasis are thought to affect the appetitive hormones: adiponectin, leptin, insulin, and ghrelin. This study examined whether centrally located fat and/or overall adiposity were related to these appetitive hormones in healthy postmenopausal women. Design: Overall and regional body composition was assessed by dual-energy X ray absorptiometry in relation to plasma adiponectin, serum leptin, serum insulin, and plasma ghrelin in 242 postmenopausal women. Results: Regression analyses revealed that the androidal-to-gynoidal fat mass ratio (18.0%), age (3.2%), and white blood cell count (1.8%) accounted for 28% of the variability in adiponectin (FZ22.2; P!0.0001); androidal (waistChip) fat mass (66.0%), androidal fat mass 2 (6.2%), wholebody lean mass (2.2%), and age (0.8%) accounted for 69% of the variability in leptin (FZ102.5; P!0.0001). Regression analyses revealed that sagittal abdominal diameter (8.4%), glucose (5.4%), white blood cell count (2.6%), and dietary u-3 fatty acids (2.0%) accounted for 32% of the variability in insulin (FZ20.8; P!0.0001); waist circumference (12.7%), hip lean mass (2.0%), and white blood cell count (1.9%) accounted for 26% of the variability in ghrelin (FZ20.7; P!0.0001). Our results indicated that centralized fat mass was the primary contributor to these appetitive hormones in healthy postmenopausal women. Conclusion: Since central adiposity in postmenopausal women was related to appetitive hormones, minimizing weight gain during the menopausal transition may optimize appetitive hormones, thereby facilitating appetite control and weight maintenance.European Journal of Endocrinology 158 889-897

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Isoflavone-rich soy protein prevents loss of hip lean mass but does not prevent the shift in regional fat distribution in perimenopausal women

Abstract: Gain in hip lean mass was greater (P = 0.014) in SPI+ than other groups, but SPI+ did not reduce the disease-promoting menopausal shift in regional fat mass.

Cited by 49 publications

References 29 publications

Six months of isoflavone supplement increases fat-free mass in obese–sarcopenic postmenopausal women: a randomized double-blind controlled trial

Six months of isoflavone supplement increases fat-free mass in obese–sarcopenic postmenopausal women: a randomized double-blind controlled trial

Legumes and soy products consumption and functional disability in older women

Centrally located body fat is related to appetitive hormones in healthy postmenopausal women.

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