Isoenzymes and Myocardial Infarction

Wróblewski, Felix; Ross, Carol; Gregory, Kenneth F.

doi:10.1056/nejm196009152631102

Cited by 126 publications

(26 citation statements)

References 3 publications

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“…Although the gel technique yielded results similar to those of the present study, detailed quantitative comparison of the results is rendered difficult by trailing of LDH activity on the starch gel in some of the experiments (32). SUM MARY 1.…”

Section: Discussionsupporting

confidence: 66%

“…During the preparation of this manuscript, two extensive studies were published on fractionation of LDH activity in mammalian tissues employing starch gel electrophoresis (32,33). Although the gel technique yielded results similar to those of the present study, detailed quantitative comparison of the results is rendered difficult by trailing of LDH activity on the starch gel in some of the experiments (32).…”

Section: Discussionmentioning

confidence: 99%

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Isozymes of Lactic Dehydrogenase in Human Tissues*

Vesell¹,

Bearn²

1961

J. Clin. Invest.

143

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Isozymes of Lactic Dehydrogenase in Human Tissues*

Vesell¹,

Bearn²

1961

J. Clin. Invest.

143

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“…LDH1 has more diagnostic value in myocardial infarc tion than total LDH activity because a rise of LDH1 persists for 8-15 h and LDH1 rises in spite of normal total LDH activity [3]. Wright et al [13] reported that both LDH1 and LDH2 rose in myocardial infarction but LDH1 rose much more.…”

Section: Discussionmentioning

confidence: 99%

“…Five isoenzymes of LDH can be demonstrated in human serum [3,5]. LDH1 and LDH2 are reported to be abundant in the myocardium and thyroid gland, while LDH4 and LDH5 are abundant in the liver and skeletal muscles [7], Therefore, analysis of different isoenzymes of LDH is of great value in the differential diagnosis of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Changes of Lactate Dehydrogenase and Its Isoenzyme Activity in Renal Diseases

Kang

Ha²,

Cho³

et al. 1991

Nephron

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Analysis of the five different serum isoenzymes of lactate dehydrogenase (LDH) is of great value in the differential diagnosis of various diseases. In order to investigate the changes of serum LDH isoenzymes in several renal diseases, 44 patients with Korean hemorrhagic fever, 10 patients with chronic renal failure, 10 patients with nephrotic syndrome, and 15 healthy subjects were studied. The isoenzymes of LDH were determined by the Helena LDH isoenzyme electrophoresis procedure. LDHl was 22.3 ± 2.8, LDH2 29.4 ± 5.1, LDH3 20.8 ± 4.5, LDH4 9.0 ± 2.7 and LDH5 8.8 ± 3.2 mU/ml in healthy subjects. In patients in the oliguric stage of Korean hemorrhagic fever, LDHl was 63.4 ± 28.5, LDH2 99.7 ± 40.7, LDH3 107.5 ± 39.0, LDH4 41.9 ± 32.8 and LDH5 37.2 ± 26.3 mU/ml, while LDHl was 23.8 ± 11.7, LDH2 38.9 ± 14.6, LDH3 36.0 ± 18.7, LDH4 13.8 ± 13.0 and LDH5 12.7 ± 7.6 mU/ml in nonoliguric patients. In patients with chronic renal failure LDH1 was 33.2 ± 10.8, LDH2 41.9 ± 13.3, LDH3 27.7 ± 8.5, LDH4 12.1 ± 6.2 and LDH5 12.3 ± 5.8 mU/ml. In patients with nephrotic syndrome, LDH1 was 25.1 ± 4.3, LDH2 33.5 ± 4.9, LDH3 23.1 ± 6.2, LDH4 8.4 ± 3.7 and LDH5 8.4 ± 3.4 mU/ml. In summary, LDH3 activity was elevated in the oliguric stage of Korean hemorrhagic fever and LDH2 was elevated in chronic renal failure; those values were correlated with the BUN level.

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“…Enzymproteine von gleicher Substratspezifität sind in ihrer Struktur nicht homogen; infolge unterschiedlicher Aminosäurenzusammen setzung lassen sie sich in einzelne Bausteine differenzieren, die man nach Markert und Moeller [8] [24] mit den Symbolen LDHj-j bezeichnet. Bei genügender Leistungsfähigkeit der verwendeten Methoden müßte es durch die isolierte Erfassung der aus dem Herzmuskel stammenden LDH-Isoenzymfraktionen (LDH1 und LDH2) möglich sein, die diagnostische Ausbeute in der Früh-und in der Spätphase, in denen die Gesamt-LDH noch oder schon wieder im Normalbereich liegt, zu verbessern.…”

Section: The Enzymatic Diagnosis Of Myocardial Infarctionunclassified

Die enzymatische Diagnostik des Herzinfarktes

Schneider¹,

Lėhmann²,

Schering³

1966

Enzymol Biol Clin

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Durch Bestimmung der LDH-Isoenzyme beim Herzinfarkt gelingt es, den Prozentsatz falsch-positiver Resultate durch LDH-Erhöhungen bei anderen Erkrankungen herabzusetzen. Bei den von uns verwendeten Methodiken zeigte sich die Agargel-Elektrophorese (n = 211) der Diaethyl-aminoaethyl-Zelluloseadsorption (n = 188) und diese sich wiederum der Hitzeinaktivierung (n = 144) überlegen. Mit Hilfe der LDH-Enzymelektrophorese ist eine Verlängerung des pathologischen Zeitraums, die Erfassung kleinerer Infarzierungen und die Lösung kombinierter Organschäden möglich.

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Isoenzymes and Myocardial Infarction

Cited by 126 publications

References 3 publications

Isozymes of Lactic Dehydrogenase in Human Tissues*

Isozymes of Lactic Dehydrogenase in Human Tissues*

Changes of Lactate Dehydrogenase and Its Isoenzyme Activity in Renal Diseases

Die enzymatische Diagnostik des Herzinfarktes

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